{"id":28193,"date":"2018-03-09T09:20:47","date_gmt":"2018-03-09T09:20:47","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-funcional-de-los-canales-de-ca2-p-q-utilizando-ratones-transgenicos-y-manipulando-su-expresion-en-celulas-cromafines\/"},"modified":"2018-03-09T09:20:47","modified_gmt":"2018-03-09T09:20:47","slug":"estudio-funcional-de-los-canales-de-ca2-p-q-utilizando-ratones-transgenicos-y-manipulando-su-expresion-en-celulas-cromafines","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-funcional-de-los-canales-de-ca2-p-q-utilizando-ratones-transgenicos-y-manipulando-su-expresion-en-celulas-cromafines\/","title":{"rendered":"Estudio funcional de los canales de ca2+ p\/q utilizando ratones transg\u00e9nicos y manipulando su expresi\u00f3n en c\u00e9lulas cromafines"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Marcos Aldea Romero <\/strong><\/h2>\n<p>La c\u00e9lula cromaf\u00edn, al igual que la neurona, presenta una gran variedad de canales de calcio dependientes de voltaje (ccdv) en su membrana. Una pregunta todav\u00eda sin resolver es para qu\u00e9 esta gran heterogeneidad de ccdv y cu\u00e1les son las funciones individuales que se pueden atribuir a cada uno de ellos en la exocitosis y en otros procesos celulares.  hasta la actualidad, el estudio de los ccdv se ha basado en la utilizaci\u00f3n de diferentes toxinas bloqueantes de canales de ca2+, con las que se han podido caracterizar durante la \u00faltima d\u00e9cada los canales de calcio de alto umbral dependientes de voltaje (l, n, p\/q y r) expresados en las c\u00e9lulas cromafines de la gl\u00e1ndula suprarrenal de diferentes especies.  vali\u00e9ndose principalmente de la t\u00e9cnica de \u00abpatch-clamp\u00bb en la configuraci\u00f3n de parche perforado para la medici\u00f3n de las corrientes de calcio y los incrementos en la capacidad de la membrana, para estimar la exocitosis, los objetivos concretos para el desarrollo de la tesis doctoral han sido:  1,- estudio de la contribuci\u00f3n de los diferentes subtipos de ccdv a la corriente de global de ca2+ y a la secreci\u00f3n utilizando ratones transg\u00e9nicos con ablaci\u00f3n de la subunidad alfa1a, que no van a expresar canales de calcio p\/q.  2,- estudio de la corriente r en c\u00e9lulas cromafines de rat\u00f3n en cultivo, que no han sido descritas anteriormente.  3,- estudio de la plasticidad de los canales de ca2+, cuando se interfiere con su conformaci\u00f3n estructural mediante el secuestro de la subunidad beta en c\u00e9lulas cromafines bovinas en cultivo. Las subunidades beta participan en la bios\u00edntesis de novo de los canales de calcio dependientes de voltaje.  para la disecci\u00f3n farmacol\u00f3gica de los distintos subtipos de canales de calcio se han utilizado los bloqueantes *-agatoxina iva, que bloquea canales p\/q, *-conotoxina gvia, que bloquea canales n y nifedipino para el bloqueo de los canales l; para bloquear la corriente a trav\u00e9s de los cana<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio funcional de los canales de ca2+ p\/q utilizando ratones transg\u00e9nicos y manipulando su expresi\u00f3n en c\u00e9lulas cromafines<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio funcional de los canales de ca2+ p\/q utilizando ratones transg\u00e9nicos y manipulando su expresi\u00f3n en c\u00e9lulas cromafines <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Marcos Aldea Romero <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 16\/01\/2004<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Antonio Garc\u00eda Garc\u00eda<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: pedro S\u00e1nchez Garc\u00eda <\/li>\n<li> Garc\u00eda-sancho martin fco. Javier (vocal)<\/li>\n<li>Juan  Luis Tamargo men\u00e9ndez (vocal)<\/li>\n<li>Antonio Rodr\u00edguez artalejo (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Marcos Aldea Romero La c\u00e9lula cromaf\u00edn, al igual que la neurona, presenta una gran variedad de canales [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[1],"tags":[2451,41020,12642,4665,80490,4664],"class_list":["post-28193","post","type-post","status-publish","format-standard","hentry","category-sin-categoria","tag-antonio-garcia-garcia","tag-antonio-rodriguez-artalejo","tag-garcia-sancho-martin-fco-javier","tag-juan-luis-tamargo-menendez","tag-marcos-aldea-romero","tag-pedro-sanchez-garcia"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/28193","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=28193"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/28193\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=28193"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=28193"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=28193"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}