{"id":28324,"date":"2018-03-09T09:20:59","date_gmt":"2018-03-09T09:20:59","guid":{"rendered":""},"modified":"2018-03-09T09:20:59","modified_gmt":"2018-03-09T09:20:59","slug":"habitos-toxicos-y-polimorfismos-geneticos-de-enzimas-metabolizadoras-de-carcinogenos-como-factores-de-riesgo-para-el-desarrollo-de-carcinomas-de-cabeza-y-cuello-estudio-de-casos-y-controles-en-poblac","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/navarra\/habitos-toxicos-y-polimorfismos-geneticos-de-enzimas-metabolizadoras-de-carcinogenos-como-factores-de-riesgo-para-el-desarrollo-de-carcinomas-de-cabeza-y-cuello-estudio-de-casos-y-controles-en-poblac\/","title":{"rendered":"H\u00e1bitos t\u00f3xicos y polimorfismos gen\u00e9ticos de enzimas metabolizadoras de carcin\u00f3genos como factores de riesgo para el desarrollo de carcinomas de cabeza y cuello. estudio de casos y controles en poblaci\u00f3n espa\u00f1ola"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Jos\u00e9 M. L\u00f3pez-picazo Gonz\u00e1lez <\/strong><\/h2>\n<p>Introducci\u00f3n  la exposici\u00f3n a carcin\u00f3genos es, probablemente, la principal causa de c\u00e1ncer y de mortalidad por c\u00e1ncer. Junto a las dosis y la duraci\u00f3n de la exposici\u00f3n, factores del individuo desempe\u00f1an un papel en la determinaci\u00f3n del riesgo de c\u00e1ncer. La mayor parte de los genes codificantes de enzimas metabolizadoras de xenobi\u00f3ticos con polim\u00f3rficas. Este hecho podr\u00eda explicar las diferencias de susceptibilidad individual. El tabaco, el alcohol y ciertas exposiciones laborales son factores de riesgo bien conocidos de c\u00e1ncer de cabeza y cuello.  objetivos. Analizar las interacciones entre tabaco, alcohol, y los polimorfismos gen\u00e9ticos en gstm1, gstt1, gastp1, cyp2e1, ephx1, nqo1 y adh3.  material y m\u00e9todos  realizamos un estudio hospitalario de casos y controles de 165 pacientes y 170 controles sanos. Analizamos muestras de adn utilizando pcr-rflp como t\u00e9cnica de genotipado. Mediante modelos de regresi\u00f3n log\u00edstica multivariante, estudiamos las relaciones entre las odds ratios (or) de carcinoma de cabeza y cuello y los genotipos, despu\u00e9s de ajustar por edad, sexo, consumo de tabaco, consumo de alcohol y exposiciones laborales.  resultados  el porcentaje de carcinomas de cabeza y cuello atribuibles al tabaco en la poblaci\u00f3n fue de 77,4% (ic95%=63,2-86,2). La exposici\u00f3n laboral a polvo de distintos or\u00edgenes result\u00f3 factor de riesgo (or=2,66; p=0,025).  globalmente no se hallaron asociaciones entre los genotipos y la susceptibilidad la c\u00e1ncer. Sin embargo, en el subgrupo de fumadores de 1 a 50 paquetes-a\u00f1o (p-a), ajustado por sexo, edad, consumo de tabaco, consumo de alcohol, y exposici\u00f3n laboral a carcin\u00f3genos, varios genotipos se asociaron con el riesgo de carcinoma de cabeza y cuello: nqo1 cc (or=5,55; p=0,008), ephx1 (pr=3,86; p=0,026), cyp2e1 c1\/c2 (or=14,01; p=0,054); gstp1 a\/a, a\/b o b\/b (or=6,94; p=0,136). El efecto de los polimorfismos fue acumulativo, produci\u00e9ndose, por cada polimorfismo desfavo<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>H\u00e1bitos t\u00f3xicos y polimorfismos gen\u00e9ticos de enzimas metabolizadoras de carcin\u00f3genos como factores de riesgo para el desarrollo de carcinomas de cabeza y cuello. estudio de casos y controles en poblaci\u00f3n espa\u00f1ola<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 H\u00e1bitos t\u00f3xicos y polimorfismos gen\u00e9ticos de enzimas metabolizadoras de carcin\u00f3genos como factores de riesgo para el desarrollo de carcinomas de cabeza y cuello. estudio de casos y controles en poblaci\u00f3n espa\u00f1ola <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Jos\u00e9 M. L\u00f3pez-picazo Gonz\u00e1lez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Navarra<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 23\/01\/2004<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Alcalde Navarrete Juan  Manuel<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: vicente Pedraza muriel <\/li>\n<li>Juan  Jes\u00fas Cruz hern\u00e1ndez (vocal)<\/li>\n<li> Llorente pendas Jos\u00e9 Luis (vocal)<\/li>\n<li>  (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Jos\u00e9 M. L\u00f3pez-picazo Gonz\u00e1lez Introducci\u00f3n la exposici\u00f3n a carcin\u00f3genos es, probablemente, la principal causa de c\u00e1ncer y [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[17749],"tags":[80773,80772,9551,25236,3714],"class_list":["post-28324","post","type-post","status-publish","format-standard","hentry","category-navarra","tag-alcalde-navarrete-juan-manuel","tag-jose-m-lopez-picazo-gonzalez","tag-juan-jesus-cruz-hernandez","tag-llorente-pendas-jose-luis","tag-vicente-pedraza-muriel"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/28324","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=28324"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/28324\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=28324"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=28324"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=28324"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}