{"id":28325,"date":"2018-03-09T09:20:59","date_gmt":"2018-03-09T09:20:59","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/efecto-de-la-lutea%c2%adna-y-de-un-complejo-multivitama%c2%adnico-con-lutea%c2%adna-y-glutation-en-un-modelo-de-estres-oxidativo-retiniano\/"},"modified":"2018-03-09T09:20:59","modified_gmt":"2018-03-09T09:20:59","slug":"efecto-de-la-lutea%c2%adna-y-de-un-complejo-multivitama%c2%adnico-con-lutea%c2%adna-y-glutation-en-un-modelo-de-estres-oxidativo-retiniano","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/navarra\/efecto-de-la-lutea%c2%adna-y-de-un-complejo-multivitama%c2%adnico-con-lutea%c2%adna-y-glutation-en-un-modelo-de-estres-oxidativo-retiniano\/","title":{"rendered":"Efecto de la lute\u00edna y de un complejo multivitam\u00ednico con lute\u00edna y glutati\u00f3n en un modelo de estr\u00e9s oxidativo retiniano"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Patricia Fern\u00e1ndez Robredo <\/strong><\/h2>\n<p>El rat\u00f3n apoe deficiente (apoe-\/-), modelo de hipercolesterolemia gen\u00e9tica, desarrolla alteraciones ultraestructurales retinianas similares a las observadas en la degeneraci\u00f3n macular asociada a la edad (dmae). Si el estr\u00e9s oxidativo estuviese relacionado con la aparici\u00f3n de dichas alteraciones, el tratamiento con antioxidantes podr\u00eda prevenir su desarrollo. Nos planteamos comprobar el estado oxidativo retiniano y determinar en epitelio pigmentado de la retina (epr)-coroides, la expresi\u00f3n del vefg y la actividad gelatinasa, as\u00ed como estudiar la ultraestructura del epr y membrana de bruch (mb) e investigar el efecto de la administraci\u00f3n de lute\u00edna o un complejo multivitam\u00ednico no lute\u00edna y glutati\u00f3n (cv) sobre dichos par\u00e1metros.  ratones apoe-\/- (n=40, 3 meses), tratados diariamente durante 3 meses con lute\u00edna o cv en dos dosis: cv-15 (15 mg\/kg\/d\u00eda) y cv-50 (50mg\/kg\/d\u00eda), se compararon con un grupo control sin tratamiento. El mismo esquema experimental se aplic\u00f3 con ratones normales (n=40).  los ratones apoe-\/- mostraron mayor estr\u00e9s oxidativo retiniano asociado con una elevada expresi\u00f3n del vegf y la actividad gelatinasa que podr\u00edan ser responsables de la aparici\u00f3n de dep\u00f3sitos laminares basales, vacuolas de aspecto vac\u00edo y engorsamiento de la mb. La suplementaci\u00f3n con el cv redujo el estr\u00e9s oxidativo plasm\u00e1tico y retiniano, expresi\u00f3n del vegf y actividad mmp-2, adem\u00e1s de prevenir la aparici\u00f3n de cambios morfol\u00f3gicos. la lute\u00edna sola no previno todas las alteraciones observadas en los apoe-\/-.  estos resultados sugieren que en los ratones apoe-\/-, el estr\u00e9s oxidativo unido al aumento de factores proangiog\u00e9nicos, podr\u00edan ser responsables, al menos en parte, de las alteraciones morfol\u00f3gicas observadas a nivel retiniano, y que dichas alteraciones son potencialmente prevenibles con tratamientos antioxidantes eficaces.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Efecto de la lute\u00edna y de un complejo multivitam\u00ednico con lute\u00edna y glutati\u00f3n en un modelo de estr\u00e9s oxidativo retiniano<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Efecto de la lute\u00edna y de un complejo multivitam\u00ednico con lute\u00edna y glutati\u00f3n en un modelo de estr\u00e9s oxidativo retiniano <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Patricia Fern\u00e1ndez Robredo <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Navarra<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 23\/01\/2004<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Alfredo Garc\u00eda Layana<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jos\u00e9 Carlos Pastor jimeno <\/li>\n<li>Javier Moreno monta\u00f1\u00e9s (vocal)<\/li>\n<li>emiliano Hern\u00e1ndez galilea (vocal)<\/li>\n<li>Manuel Vidal sanz (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Patricia Fern\u00e1ndez Robredo El rat\u00f3n apoe deficiente (apoe-\/-), modelo de hipercolesterolemia gen\u00e9tica, desarrolla alteraciones ultraestructurales retinianas similares [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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