{"id":28337,"date":"2018-03-09T09:21:00","date_gmt":"2018-03-09T09:21:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-de-la-expresion-genica-y-de-la-impronta-genomica-de-arhi-noey2-p73-y-peg1-mest-en-la-cirrosis-y-en-el-hepatocarcinoma\/"},"modified":"2018-03-09T09:21:00","modified_gmt":"2018-03-09T09:21:00","slug":"estudio-de-la-expresion-genica-y-de-la-impronta-genomica-de-arhi-noey2-p73-y-peg1-mest-en-la-cirrosis-y-en-el-hepatocarcinoma","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/navarra\/estudio-de-la-expresion-genica-y-de-la-impronta-genomica-de-arhi-noey2-p73-y-peg1-mest-en-la-cirrosis-y-en-el-hepatocarcinoma\/","title":{"rendered":"Estudio de la expresi\u00f3n g\u00e9nica y de la impronta gen\u00f3mica de arhi\/noey2, p73 y peg1\/mest en la cirrosis y en el hepatocarcinoma"},"content":{"rendered":"

Tesis doctoral de Calvo Ferrer M. Alicia <\/strong><\/h2>\n

Dadas las alteraciones descritas para el cluster de impronta del gen igf2 en el hepatocarcinoma (hcc), se plante\u00f3 la hip\u00f3tesis de que las alteraciones de la impronta gen\u00f3mica supusieran un mecanismo general en la patog\u00e9nesis de la cirrosis y el hcc. Para comprobarlo se han investigado en h\u00edgados sanos, cirr\u00f3ticos y en hcc las posibles alteraciones de la expresi\u00f3n y de la impronta de tres genes improntados alterados en otros procesos tumorales: arhi\/noey2, p73 y peg1\/mest, mediante rt-pcr convencional, rt-pcr en tiempo real y rflp. arhi\/noey – estudio de la expresi\u00f3n g\u00e9nica: los resultados obtenidos sugieren que el gen arhi se expresa de forma constitutiva en el h\u00edgado y que su expresi\u00f3n no se altera en el desarrollo del da\u00f1o hep\u00e1tico. – estudio de la impronta gen\u00f3mica: los resultados parecen indicar que la expresi\u00f3n constitutiva de arhi en el h\u00edgado es monoal\u00e9lica y que este estado no se altera enla enfermedad hep\u00e1tica. p73 – estudio de la expresi\u00f3n g\u00e9nica: se ha observado que el promotor activo en el h\u00edgado es ta-p73 y que la isoforma ta-p73, con funci\u00f3n supresora de tumor, se expresa de forma constitutiva. En la cirrosis y en el hepatocarcinoma se produce una exresi\u00f3n de novo de la isoforma oncog\u00e9nica p73-*ex2, lo que podr\u00eda deberse a una alteraci\u00f3n de los factores de corte y empalme alternativos necesarios para su procesamiento. La expresi\u00f3n de p73-*ex2 en un h\u00edgado sano podr\u00eda constituir un factor de predisposici\u00f3n para el desarrollo de un hcc, ya que su expresi\u00f3n seh ha visto inducida en los h\u00edgados sanos que albergan un hcc. – estudio de la impronta gen\u00f3mica: la expresi\u00f3n de p73 en el h\u00edgado es bial\u00e9lica por lo que la impronta no est\u00e1 implicada en las alteraciones de expresi\u00f3n observadas. peg1\/mest – estudio de la expresi\u00f3n g\u00e9nica: se ha observado en el h\u00edgado sano se expresan de forma constitutiva tanto la isoforma 1 como la isoforma 2 de peg1. En la cirrosis se produce un<\/p>\n

 <\/p>\n

Datos acad\u00e9micos de la tesis doctoral \u00abEstudio de la expresi\u00f3n g\u00e9nica y de la impronta gen\u00f3mica de arhi\/noey2, p73 y peg1\/mest en la cirrosis y en el hepatocarcinoma<\/strong>\u00ab<\/h3>\n
    \n
  • T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio de la expresi\u00f3n g\u00e9nica y de la impronta gen\u00f3mica de arhi\/noey2, p73 y peg1\/mest en la cirrosis y en el hepatocarcinoma <\/li>\n
  • Autor:<\/strong>\u00a0 Calvo Ferrer M. Alicia <\/li>\n
  • Universidad:<\/strong>\u00a0 Navarra<\/li>\n
  • Fecha de lectura de la tesis:<\/strong>\u00a0 24\/01\/2004<\/li>\n<\/ul>\n

     <\/p>\n

    Direcci\u00f3n y tribunal<\/h3>\n
      \n
    • Director de la tesis<\/strong>\n
        \n
      • Mar\u00eda Del Carmen Berasain Lasarte<\/li>\n<\/ul>\n<\/li>\n
      • Tribunal<\/strong>\n
          \n
        • Presidente del tribunal: Jes\u00fas m. Prieto valtue\u00f1a <\/li>\n
        • Luis Torres asensi (vocal)<\/li>\n
        • agust\u00edn Albillos mart\u00ednez (vocal)<\/li>\n
        • cruz Santos tejedor (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n

           <\/p>\n","protected":false},"excerpt":{"rendered":"

          Tesis doctoral de Calvo Ferrer M. Alicia Dadas las alteraciones descritas para el cluster de impronta del gen igf2 en […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[17749],"tags":[31696,80798,15421,15059,48933,80799],"class_list":["post-28337","post","type-post","status-publish","format-standard","hentry","category-navarra","tag-agustin-albillos-Martinez","tag-calvo-ferrer-m-alicia","tag-cruz-santos-tejedor","tag-jesus-m-prieto-valtuena","tag-luis-torres-asensi","tag-maria-del-carmen-berasain-lasarte"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/28337","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=28337"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/28337\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=28337"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=28337"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=28337"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}