{"id":28412,"date":"2018-03-09T09:21:06","date_gmt":"2018-03-09T09:21:06","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/1-y-4-alquil-24-dihidro-1h-pirazino21-bquinazolina-36-dionas-como-sintones-analogos-de-ardeemina\/"},"modified":"2018-03-09T09:21:06","modified_gmt":"2018-03-09T09:21:06","slug":"1-y-4-alquil-24-dihidro-1h-pirazino21-bquinazolina-36-dionas-como-sintones-analogos-de-ardeemina","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/1-y-4-alquil-24-dihidro-1h-pirazino21-bquinazolina-36-dionas-como-sintones-analogos-de-ardeemina\/","title":{"rendered":"1 y 4-alquil-2,4-dihidro-1h-pirazino(2,1-b)quinazolina-3,6-dionas como sintones an\u00e1logos de ardeemina"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Fernando Hern\u00e1ndez Blanco <\/strong><\/h2>\n<p>La n-acetil ardeemina es un potente agente reversor mdr. En este trabajo se ha llevado un estudio completo de s\u00edntesis estereoselectiva y evaluaci\u00f3n de sistemas tric\u00edclicos que contienen los anillos d, e, f, de esta estructura. se han estudiado reacciones de sustituci\u00f3n electr\u00f3fila en posiciones uno y cuatro con derivados halogenados y aceptores de michael, obteni\u00e9ndose estructuras regio y estereoselectivas. A su vez se han puesto a punto rutas de s\u00edntesis estereoselectivas y f\u00e1ciles para obtener los productos naturales fumiquinazolina y fiscalina y del sistema hexac\u00edclico de \u00ab-prenil-\u00bb ardemina. as\u00ed mismo se han obtenido sistemas penta y tetrac\u00edclicos an\u00e1logos de ardeemina empleando los imino\u00e9teres de pirazino [2,1-b] quinazolina -3, 6-dionas. los compuestos obtenidos se han valorado por hplc quiral, cuya t\u00e9cnica se ha puesto a punto en este trabajo.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>1 y 4-alquil-2,4-dihidro-1h-pirazino(2,1-b)quinazolina-3,6-dionas como sintones an\u00e1logos de ardeemina<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 1 y 4-alquil-2,4-dihidro-1h-pirazino(2,1-b)quinazolina-3,6-dionas como sintones an\u00e1logos de ardeemina <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Fernando Hern\u00e1ndez Blanco <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 30\/01\/2004<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> S\u00c1\u00b6llhuber Kretzer M\u00f3nica M.<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: diego Armesto vilas <\/li>\n<li>Javier Guti\u00e9rrez Luis (vocal)<\/li>\n<li>Francisco Palacios gambra (vocal)<\/li>\n<li> Molina orden Mar\u00eda  teresa (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Fernando Hern\u00e1ndez Blanco La n-acetil ardeemina es un potente agente reversor mdr. En este trabajo se ha [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[1],"tags":[6598,80963,33655,4207,80965,80964],"class_list":["post-28412","post","type-post","status-publish","format-standard","hentry","category-sin-categoria","tag-diego-armesto-vilas","tag-fernando-hernandez-blanco","tag-francisco-palacios-gambra","tag-javier-gutierrez-luis","tag-molina-orden-maria-teresa","tag-sallhuber-kretzer-monica-m"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/28412","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=28412"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/28412\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=28412"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=28412"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=28412"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}