{"id":28546,"date":"2004-06-02T00:00:00","date_gmt":"2004-06-02T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/parta%c2%adcula-de-reconocimiento-de-la-senal-en-yarrowia-lipolytica-caracterizacion-del-gen-yisrp72-y-analisis-del-peptido-senal\/"},"modified":"2004-06-02T00:00:00","modified_gmt":"2004-06-02T00:00:00","slug":"parta%c2%adcula-de-reconocimiento-de-la-senal-en-yarrowia-lipolytica-caracterizacion-del-gen-yisrp72-y-analisis-del-peptido-senal","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/salamanca\/parta%c2%adcula-de-reconocimiento-de-la-senal-en-yarrowia-lipolytica-caracterizacion-del-gen-yisrp72-y-analisis-del-peptido-senal\/","title":{"rendered":"Part\u00edcula de reconocimiento de la se\u00f1al en yarrowia lipolytica: caracterizaci\u00f3n del gen yisrp72 y an\u00e1lisis del p\u00e9ptido se\u00f1al."},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Ruiz Pavon Lorena Beatriz <\/strong><\/h2>\n<p>En levaduras existen al menos dos v\u00edas de transporte de las prote\u00ednas de secreci\u00f3n a trav\u00e9s del ret\u00edculo endopl\u00e1smico. En la v\u00eda contraduccional dependiente de la srp, \u00e9sta se une a la secuencia se\u00f1al cuando emerge la prote\u00edna que se est\u00e1 sintetizando en el ribosoma. Esta interacci\u00f3n provoca una pausa en la elongaci\u00f3n y en la traducci\u00f3n de la prote\u00edna. Una vez que el complejo srp-ribosoma-prote\u00edna naciente llegan a la membrana del ret\u00edculo endopl\u00e1smico, la prote\u00edna es translocada al lumen a la vez que contin\u00faa su s\u00edntesis. Los eventos de translocaci\u00f3n son llevados a cabo por un complejo proteico de la membrana del re, el transloc\u00f3n.  la part\u00edcula del reconocimiento de la se\u00f1al se compone de un 7slrna y seis polip\u00e9ptidos. El aislamiento de los componentes de la srp en yarrowia lipolytica es el primer paso para el estudio de su funci\u00f3n. La maquinaria de translocaci\u00f3n de yarrowia lipolytica presenta nuevas caracter\u00edsticas frente a las de saccharomyces cerevisiae.  el gen yisrp72 codifica una prote\u00edna putativa de 538 animo \u00e1cidos (mw, 59,5 kda). El an\u00e1lisis de northern blot mostr\u00f3 un transcrit\u00f3 \u00fanico de yisrp72 de 1.8 kb. As\u00ed mismo se encontr\u00f3 que la secuencia de amino\u00e1cidos de la prote\u00edna yisrp72p presenta identidad con la prote\u00edna srp72p de otras levaduras (saccharomyces cerevisiae y schizosaccharomyces pombe). La interrupci\u00f3n del gen yisrp72, se llev\u00f3 a cabo por el m\u00e9todo de pop out y se encontr\u00f3 que la deleci\u00f3n del gen yisrp72 es letal para el microorganismo. Esto concuerda con el obtenido en los resultados para otro componente de la srp, el gen yisec652.  la microscopia fluorescente nos mostr\u00f3 que la fusi\u00f3n yisrp72-gfpp se localiza en el citoplasma  las mutaciones en la posici\u00f3n -1 de un p\u00e9ptido se\u00f1al sint\u00e9tico par y. Lipolytica produjeron cambios en la secreci\u00f3n de la enzima invertasa obtenida de s. cerevisiae. La sustituci\u00f3n de alanina por fenilalanina produjo un incremento en la<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Part\u00edcula de reconocimiento de la se\u00f1al en yarrowia lipolytica: caracterizaci\u00f3n del gen yisrp72 y an\u00e1lisis del p\u00e9ptido se\u00f1al.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Part\u00edcula de reconocimiento de la se\u00f1al en yarrowia lipolytica: caracterizaci\u00f3n del gen yisrp72 y an\u00e1lisis del p\u00e9ptido se\u00f1al. <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Ruiz Pavon Lorena Beatriz <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Salamanca<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 06\/02\/2004<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>\u00e1ngel Dom\u00ednguez Olavarri<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Miguel Vi\u00f1as ciodia <\/li>\n<li>altino Choupina branco (vocal)<\/li>\n<li>Jos\u00e9 Mar\u00eda D\u00edaz m\u00ednguez (vocal)<\/li>\n<li>Jes\u00fas Zueco cruz (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Ruiz Pavon Lorena Beatriz En levaduras existen al menos dos v\u00edas de transporte de las prote\u00ednas de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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