{"id":28565,"date":"2004-06-02T00:00:00","date_gmt":"2004-06-02T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/factores-neurohormonales-inflamatorios-y-reserva-de-flujo-coronario-analisis-y-correlacion-en-pacientes-con-y-sin-insuficiencia-carda%c2%adaca\/"},"modified":"2004-06-02T00:00:00","modified_gmt":"2004-06-02T00:00:00","slug":"factores-neurohormonales-inflamatorios-y-reserva-de-flujo-coronario-analisis-y-correlacion-en-pacientes-con-y-sin-insuficiencia-carda%c2%adaca","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/navarra\/factores-neurohormonales-inflamatorios-y-reserva-de-flujo-coronario-analisis-y-correlacion-en-pacientes-con-y-sin-insuficiencia-carda%c2%adaca\/","title":{"rendered":"Factores neurohormonales, inflamatorios y reserva de flujo coronario: an\u00e1lisis y correlaci\u00f3n en pacientes con y sin insuficiencia card\u00edaca"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Alfonso Mac\u00edas Gallego <\/strong><\/h2>\n<p>La insuficiencia card\u00edaca se ha convertido en una enfermedad cardiovascular de gran repercusi\u00f3n sanitaria, econ\u00f3mica y social. En su fisiopatolog\u00eda se han implicado factores neurohormonales, inflamatorios y citoquinas y m\u00e1s recientemente gen\u00e9ticos y moleculares. Por otro lado tambi\u00e9n se ha observado que existe una alteraci\u00f3n en la reserva de flujo coronario de estos pacientes aun en ausencia de lesiones coronarias, quiz\u00e1s por una alteraci\u00f3n en la microvasculatura.  el objetivo de este trabajo fue el de anallizar los valores sangu\u00edneos de ciertos factores neurohormonales e inflamatorios, as\u00ed como cuantificar la reserva coronaria mediante tomograf\u00eda de emisi\u00f3n de positrones (pet) en pacientes con y sin insuficiencia card\u00edaca de etiolog\u00eda no isqu\u00e9mica. posteriormente se estudi\u00f3 la posible correlaci\u00f3n existente entre los factores medidos.  se incluyeron en el estudio 100 pacientes que se dividieron en 5 grupos de 20 cada uno: pacientes con cardiopat\u00eda estructural pero sin insuficiencia card\u00edaca (grupo 1), pacientes en clase funcional i (grupo 2), ii en tratamiento con carvedilol e inhibidores de la enzima de conversi\u00f3n (grupo 3), ii que no recib\u00edan carvedilol (grupo 4) y iii-iv (grupo 5). En todos ellos se descart\u00f3 la presencia de cardiopat\u00eda isqu\u00e9mica con t\u00e9cnicas isot\u00f3picas o de imagen en el grupo 1 y mediante coronariograf\u00eda en el resto de grupos.  los factores neurohormonales medidos fueron la noradrenalina (na), angiotensina ii (ag-ii), endotelina-1 (et-1), p\u00e9ptido natriur\u00e9tico auricular (pna) y p\u00e9ptido natriur\u00e9tico cerebral (pnc). De entre los inflamatorios se analizaron el factor de necrosis tumoral alfa (tnf), interleuquina 1b (il-1b), interleuquina 6 (il-6) y receptor soluble de la interleuquina 2 (sil-2r). Se realiz\u00f3 un estudio pet a 10 pacientes de cada grupo con insuficiencia card\u00edaca, cuantific\u00e1ndose el flujo mioc\u00e1rdico basal y tras atp y la reserva coronaria (flujo atp\/flujo basal).  no h<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Factores neurohormonales, inflamatorios y reserva de flujo coronario: an\u00e1lisis y correlaci\u00f3n en pacientes con y sin insuficiencia card\u00edaca<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Factores neurohormonales, inflamatorios y reserva de flujo coronario: an\u00e1lisis y correlaci\u00f3n en pacientes con y sin insuficiencia card\u00edaca <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Alfonso Mac\u00edas Gallego <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Navarra<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 06\/02\/2004<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Isabel Coma Canella<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: diego Mart\u00ednez caro <\/li>\n<li>Mar\u00eda  g. Crespo leiro (vocal)<\/li>\n<li> R\u00edo ligorit alfonso de (vocal)<\/li>\n<li> Garc\u00eda bolao Jos\u00e9 ignacio (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Alfonso Mac\u00edas Gallego La insuficiencia card\u00edaca se ha convertido en una enfermedad cardiovascular de gran repercusi\u00f3n sanitaria, [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[17749],"tags":[81287,18298,32128,81288,81289,81290],"class_list":["post-28565","post","type-post","status-publish","format-standard","hentry","category-navarra","tag-alfonso-macias-gallego","tag-diego-Martinez-caro","tag-garcia-bolao-jose-ignacio","tag-isabel-coma-canella","tag-maria-g-crespo-leiro","tag-rio-ligorit-alfonso-de"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/28565","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=28565"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/28565\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=28565"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=28565"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=28565"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}