{"id":28667,"date":"2018-03-09T09:21:28","date_gmt":"2018-03-09T09:21:28","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/efectos-farmacologicos-y-farmacocinetica-de-la-34-metilenodioximetanfetamina-mdma-extasis-a-dosis-multiples-y-en-diferentes-intervalos-de-administracion-en-humanos\/"},"modified":"2018-03-09T09:21:28","modified_gmt":"2018-03-09T09:21:28","slug":"efectos-farmacologicos-y-farmacocinetica-de-la-34-metilenodioximetanfetamina-mdma-extasis-a-dosis-multiples-y-en-diferentes-intervalos-de-administracion-en-humanos","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/efectos-farmacologicos-y-farmacocinetica-de-la-34-metilenodioximetanfetamina-mdma-extasis-a-dosis-multiples-y-en-diferentes-intervalos-de-administracion-en-humanos\/","title":{"rendered":"Efectos farmacol\u00f3gicos y farmacocin\u00e9tica de la 3,4-metilenodioximetanfetamina (mdma, \u00e9xtasis) a dosis m\u00faltiples y en diferentes intervalos de administraci\u00f3n en humanos"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Ana M. Peir\u00f3 Peir\u00f3 <\/strong><\/h2>\n<p>La 3,4-metilenodioximetanfetamina (mdma, \u00e9xtasis) es un derivado de la  metanfetamina con estructura qu\u00edmica parecida a la mescalina. La mdma es una de las sustancias psicoactivas de mayor consumo recreacional. A nivel mundial se se\u00f1ala que cerca de un 4% de la poblaci\u00f3n la ha consumido \u00e9xtasis \u00abalguna vez\u00bb. La pauta m\u00e1s com\u00fan de consumo de \u00e9xtasis es a dosis m\u00faltiple, sin embargo, la mayor\u00eda de estudios realizados en humanos hasta la fecha lo fueron en administraci\u00f3n \u00fanica. El objetivo de este trabajo fue estudiar la administraci\u00f3n de mdma a dosis repetidas en dos intervalos distintos. se dise\u00f1aron dos estudios aleatorizados, doble ciego, cruzados y controlados con placebo con intervalos de administraci\u00f3n de 2 horas (mdma2h) y de 24 horas (mdmd24h) en voluntarios sanos. Ambos estudios se desarrollaron en dos sesiones experimentales separadas por dos semanas (periodo de lavado). en mdma2h (n=129 las condiciones de administraci\u00f3n fueron placebo o 50 mg mdma y transcurridas 2 horas en ambos casos 100 mg de mdma. En mdma24h (n=10) las condiciones fueron placebo o 100 mg mdma y transcurridas 24 horas placebo o 100 mg mdma. Se evaluaron de forma continuada par\u00e1metros fisiol\u00f3gicos, subjetivos y de rendimiento psicomotor, obteni\u00e9ndose muestras de snagre para determinar las concentraciones de mdma y metab\u00f3litos.  en ambos resultados, la administraci\u00f3n de mdma a dosis \u00fanicas produjo en el \u00e1rea fisiol\u00f3gica, un aumento significativo de la presi\u00f3n arterial, frecuencia cardiaca, temperatura, midriasis, esoforia y empeoramiento ligero del rendimiento psicomotor. En el \u00e1rea de los efectos subjetivos prodjo sensaciones de euforia, bienestar, estimulaci\u00f3n y leves cambios en las percepciones corporales sin alucinaciones. La administraci\u00f3n de mdma a dosis repetidas produjo todos los efectos anteriormente mencionados pero con una magnitud mayor. debe considerarse que, tras la segunda dosis, las concentraciones plasm\u00e1ticas de la m<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Efectos farmacol\u00f3gicos y farmacocin\u00e9tica de la 3,4-metilenodioximetanfetamina (mdma, \u00e9xtasis) a dosis m\u00faltiples y en diferentes intervalos de administraci\u00f3n en humanos<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Efectos farmacol\u00f3gicos y farmacocin\u00e9tica de la 3,4-metilenodioximetanfetamina (mdma, \u00e9xtasis) a dosis m\u00faltiples y en diferentes intervalos de administraci\u00f3n en humanos <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Ana M. Peir\u00f3 Peir\u00f3 <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 13\/02\/2004<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Mag\u00ed Farr\u00e9 Albaladejo<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jos\u00e9 Francisco Horga de la parte <\/li>\n<li>Rafael De la torre fornell (vocal)<\/li>\n<li>Marta Torrens melich (vocal)<\/li>\n<li>josep eladi Ba\u00f1os diez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Ana M. Peir\u00f3 Peir\u00f3 La 3,4-metilenodioximetanfetamina (mdma, \u00e9xtasis) es un derivado de la metanfetamina con estructura qu\u00edmica [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[1],"tags":[81518,27438,6259,13915,33924,81519],"class_list":["post-28667","post","type-post","status-publish","format-standard","hentry","category-sin-categoria","tag-ana-m-peiro-peiro","tag-jose-francisco-horga-de-la-parte","tag-josep-eladi-banos-diez","tag-magi-farre-albaladejo","tag-marta-torrens-melich","tag-rafael-de-la-torre-fornell"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/28667","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=28667"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/28667\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=28667"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=28667"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=28667"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}