{"id":28675,"date":"2018-03-09T09:21:28","date_gmt":"2018-03-09T09:21:28","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/alteraciones-del-sistema-coagulacion-fibrinolisis-en-el-adenocarcinoma-colorrectal\/"},"modified":"2018-03-09T09:21:28","modified_gmt":"2018-03-09T09:21:28","slug":"alteraciones-del-sistema-coagulacion-fibrinolisis-en-el-adenocarcinoma-colorrectal","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/alcala\/alteraciones-del-sistema-coagulacion-fibrinolisis-en-el-adenocarcinoma-colorrectal\/","title":{"rendered":"Alteraciones del sistema coagulacion\/fibrinolisis en el adenocarcinoma colorrectal."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Julio Galindo Alvarez <\/strong><\/h2>\n<p>Introducci\u00f3n:  las alteraciones de la coagulaci\u00f3n-fibrinolisis en el c\u00e1ncer son conocidas y bien documentadas desde hace 150 a\u00f1os, teniendo actualmente importantes nexos de uni\u00f3n con el sistema inflamatorio y la angiog\u00e9nesis, que son unos mecanismos fundamentales dentro de la fisiolog\u00eda tumoral.  hip\u00f3tesis y objetivos:  el adenocarcinoma c\u00f3lico utiliza el sistema de coagulaci\u00f3n y fibrinolisis como mecanismo de invasi\u00f3n y adhesi\u00f3n tumoral, favoreciendo un estado basal de hipercoagulabilidad, independiente del acto quir\u00fargico.Se definen las alteraciones del sistema coagulaci\u00f3n y fibrinolisis, identificando las alteraciones debidas al proceso tumoral y diferenciandolas de las quir\u00fargicas, elaborando una teor\u00eda fisiol\u00f3gica del proceso de adhesi\u00f3n tumoral, invasi\u00f3n y met\u00e1stasis.  metodolog\u00eda:  estudio observacional, descriptivo y anal\u00edtico, longitudinal y prospectivo, analizando los factores de coagulaci\u00f3n y fibrinolisis (factor vii, antitrombina iii, complejos tat, prote\u00edna c, fibrin\u00f3geno, t-pa, pai-1 y d\u00edmero d), par\u00e1metros preoperatorios (cea), anatom\u00eda patol\u00f3gica y seguimiento a 60 meses. Se determinan los factores previos en sangre perif\u00e9rica previo a la cirug\u00eda, y posteriormente se toma una muestra de la sangre de drenaje tumoral (previa disecci\u00f3n quir\u00fargica de la misma) y de vena perif\u00e9rica de forma simult\u00e1nea.  resultados:  la recidiva tumoral se ha presentado en un 0% (50%) de dukes a, 44,4% (77,78%) b, 28,6% (71,42%) c y 100% (50%) en estadio d, estando indicado entre par\u00e9ntesis la supervivencia real a 5 a\u00f1os. Entre los pacientes con recidiva y los sin-recidiva, no existieron diferencias significativas entre los factores estudiados, aunque s\u00ed medias m\u00e1s elevadas de tat.  tpa.- Elevaci\u00f3n significativas entre sangre perif\u00e9rica antes y durante la cirug\u00eda, y tambi\u00e9n entre sangre perif\u00e9rica previa a la cirug\u00eda y sangre de drenaje tumoral.  d\u00edmero d.- Incremento significativa entre p<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Alteraciones del sistema coagulacion\/fibrinolisis en el adenocarcinoma colorrectal.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Alteraciones del sistema coagulacion\/fibrinolisis en el adenocarcinoma colorrectal. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Julio Galindo Alvarez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Alcal\u00e1<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 13\/02\/2004<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Angel Garcia Avello<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: M\u00aa  vicenta (secretario) Collado guirao <\/li>\n<li>tomasa Centella hern\u00e1ndez (vocal)<\/li>\n<li>Jes\u00fas Igea de pablo (vocal)<\/li>\n<li>  (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Julio Galindo Alvarez Introducci\u00f3n: las alteraciones de la coagulaci\u00f3n-fibrinolisis en el c\u00e1ncer son conocidas y bien documentadas [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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