{"id":28705,"date":"2018-03-09T09:21:31","date_gmt":"2018-03-09T09:21:31","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/patron-de-expresion-intrahepatico-de-la-ciclooxigenasa-2-en-la-infeccion-cronica-por-el-virus-c-papel-patogenico-en-fibrogenesis-y-carcinogenesis\/"},"modified":"2018-03-09T09:21:31","modified_gmt":"2018-03-09T09:21:31","slug":"patron-de-expresion-intrahepatico-de-la-ciclooxigenasa-2-en-la-infeccion-cronica-por-el-virus-c-papel-patogenico-en-fibrogenesis-y-carcinogenesis","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/patron-de-expresion-intrahepatico-de-la-ciclooxigenasa-2-en-la-infeccion-cronica-por-el-virus-c-papel-patogenico-en-fibrogenesis-y-carcinogenesis\/","title":{"rendered":"Patr\u00f3n de expresi\u00f3n intrahep\u00e1tico de la ciclooxigenasa-2 en la infecci\u00f3n cr\u00f3nica por el virus c: papel patog\u00e9nico en fibrog\u00e9nesis y carcinog\u00e9nesis"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Oscar N\u00fa\u00f1ez Martinez <\/strong><\/h2>\n<p>La ciclooxigenasa (cox) es la enzima encargada del a bios\u00edntesis de las pg. Su informaci\u00f3n inducible, denominada cox-2, ha sido implicada en m\u00faltiples procesos patol\u00f3gicos como inflamaci\u00f3n, fibrog\u00e9nesis y carcinog\u00e9nesis. Diferentes autores han descrito que el aumento de la expresi\u00f3n intrahep\u00e1tica dela cox-2 y de la producci\u00f3n de pg podr\u00eda contribuir a la lesi\u00f3n hep\u00e1tica y a la aparici\u00f3n de hepatocarcinoma (chc). En nuestro medio la infecci\u00f3n por el virus de la hepatitis c (vhc) es una causa importante de hepatitis cr\u00f3nica (hc), cirrosis hep\u00e1tica (ch) y chc, y por tanto de una morbi-mortalidad significativa.  los objetivos principales de este trabajo de tesis doctoral han sido valorar la expresi\u00f3n y localizaci\u00f3n de la cox-2 en la hc por vhc y su relaci\u00f3n con la gravedad de la lesi\u00f3n hep\u00e1tica. Otros objetivos analizados han sido comparar la expresi\u00f3n de la cox-2 en la hc por vhc con la hepatopat\u00eda alcoh\u00f3lica, la expresi\u00f3n y relaci\u00f3n de las mmps con la cox-2, en la infecci\u00f3n cr\u00f3nica por el vhc, y la valoraci\u00f3n de la asociaci\u00f3n entre los niveles de expresi\u00f3n intrahep\u00e1tica de la cox-2 con las caracter\u00edsticas cl\u00ednicas, bioqu\u00edmicas, virol\u00f3gicas e histol\u00f3gicas de los pacientes con infecci\u00f3n cr\u00f3nica por el vhc.  se han estudiado 51 pacientes, de los cuales 32 ten\u00edan una infecci\u00f3n cr\u00f3nica por el vhc (5 con ch), 9 una hepatopat\u00eda alcoh\u00f3lica (6 con ch) y 10 pacientes como grupo control compuestos de 4 pacientes con h\u00edgado histol\u00f3gicamente normal y 6 con esteatosis hep\u00e1tica no alcoh\u00f3lica. Para determinar la cox-2 en muestras de tejido hep\u00e1tico se realizaron t\u00e9cnicas de western blot, rt-pcr y de inmunohistoqu\u00edmica. Adem\u00e1s se determin\u00f3 la producci\u00f3n de pg por t\u00e9cnicas de elisa para valorar la funcionalidad de la enzima. Tambi\u00e9n se estudi\u00f3 mediante western blot la expresi\u00f3n intrahep\u00e1tica de mmp-2 y mmp-9 y la actividad de la mmp-9 con un ensayo espec\u00edfico.  el an\u00e1lisis por western blot de la<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Patr\u00f3n de expresi\u00f3n intrahep\u00e1tico de la ciclooxigenasa-2 en la infecci\u00f3n cr\u00f3nica por el virus c: papel patog\u00e9nico en fibrog\u00e9nesis y carcinog\u00e9nesis<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Patr\u00f3n de expresi\u00f3n intrahep\u00e1tico de la ciclooxigenasa-2 en la infecci\u00f3n cr\u00f3nica por el virus c: papel patog\u00e9nico en fibrog\u00e9nesis y carcinog\u00e9nesis <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Oscar N\u00fa\u00f1ez Martinez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 17\/02\/2004<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Gerardo Clemente Ricote<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: jose De portugal  alvarez <\/li>\n<li>v\u00edctor S\u00e1nchez turri\u00f3n (vocal)<\/li>\n<li>valent\u00edn Cuervas-mons mart\u00ednez (vocal)<\/li>\n<li>Manuel De la mata garcia (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Oscar N\u00fa\u00f1ez Martinez La ciclooxigenasa (cox) es la enzima encargada del a bios\u00edntesis de las pg. Su [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[1],"tags":[14316,9552,2045,81591,29649,30147],"class_list":["post-28705","post","type-post","status-publish","format-standard","hentry","category-sin-categoria","tag-gerardo-clemente-ricote","tag-jose-de-portugal-alvarez","tag-manuel-de-la-mata-garcia","tag-oscar-nunez-Martinez","tag-valentin-cuervas-mons-Martinez","tag-victor-sanchez-turrion"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/28705","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=28705"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/28705\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=28705"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=28705"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=28705"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}