{"id":28710,"date":"2018-03-09T09:21:31","date_gmt":"2018-03-09T09:21:31","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/modulacion-terapeutica-de-los-mecanismos-moleculares-de-la-muerte-celular-en-el-tubulo-renal\/"},"modified":"2018-03-09T09:21:31","modified_gmt":"2018-03-09T09:21:31","slug":"modulacion-terapeutica-de-los-mecanismos-moleculares-de-la-muerte-celular-en-el-tubulo-renal","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/modulacion-terapeutica-de-los-mecanismos-moleculares-de-la-muerte-celular-en-el-tubulo-renal\/","title":{"rendered":"Modulaci\u00f3n terap\u00e9utica de los mecanismos moleculares de la muerte celular en el t\u00fabulo renal"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Justo D\u00edaz M. Pilar <\/strong><\/h2>\n<p>La muerte de c\u00e9lulas tubulares es el \u00fanico par\u00e1metro histol\u00f3gico que se correlaciona con el grado de insuficiencia renal durante el fracaso renal agudo por necrosis tubular aguda.  adem\u00e1s, la atrof\u00eda tubular de la insuficiencia renal cr\u00f3nica se debe a la muerte de las c\u00e9lulas tubulares. Sin embargo los mecanismos moleculares de la muerte del epitelio tubular renal son pocos conocidos. La comprensi\u00f3n de estos mecanismos puede llevar al dise\u00f1o de nuevas estrategias terap\u00e9uticas en pacientes con insuficiencia renal, una situaci\u00f3n cl\u00ednica con enormes implicaciones econ\u00f3micas y sociales.  hemos profundizado en los mecanismos del efecto letal de factores patog\u00e9nicos end\u00f3genos (citoquinas) y ex\u00f3genos (nefrot\u00f3xicos: paracetamol y ciclosporina a). Ambos nefrot\u00f3xicos producen apoptosis en c\u00e9lulas del epitelio tubular renal. Hemos observado que el mecanismo de acci\u00f3n de estos nefrot\u00f3xicos es completamente diferente. La csa produce da\u00f1o mitocondrial dependiente de bax y caspasa-2, y los inhibidores de caspasas aumentan la supervivencia celular a largo plazo. Sin embargo, el paracetamol induce lesi\u00f3n del ret\u00edculo endopl\u00e1smico y la inhibici\u00f3n de caspasas evita la apoptosis pero no la muerte celular. En el transcurso de estudios del papel de fadd en la apoptosis por nefrot\u00f3xicos, observamos que la sobreexpresi\u00f3n de la prote\u00edna fadd produc\u00eda apoptosis de c\u00e9lulas tubulares, pero contrariamente a lo esperado, la sobreexpresi\u00f3n de la fadd-dn (dominante negativo, carece del \u00abdeath effector domain\u00bb) tambi\u00e9n produc\u00eda apoptosis en estas c\u00e9lulas. Adem\u00e1s, abordamos el efecto de la citoquina letal tweak y su receptor fn 14 en el epitelio tubular renal. En presencia de un microambiente proinflamatorio, tweak induce apoptosis dependiente de caspasas del epitelio tubular. Sin embargo, la inhibici\u00f3n de caspasas favorece la lesi\u00f3n oxidativa y la muerte necr\u00f3tica de la c\u00e9lula.  esta informaci\u00f3n puede ser \u00fatil para dise\u00f1ar ab<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Modulaci\u00f3n terap\u00e9utica de los mecanismos moleculares de la muerte celular en el t\u00fabulo renal<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Modulaci\u00f3n terap\u00e9utica de los mecanismos moleculares de la muerte celular en el t\u00fabulo renal <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Justo D\u00edaz M. Pilar <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 17\/02\/2004<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Alberto Ortiz Arduan<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: manuel Oya otero <\/li>\n<li>Francisco Mampaso (vocal)<\/li>\n<li>Fernando Lia\u00f1o (vocal)<\/li>\n<li>Alberto Tejedor (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Justo D\u00edaz M. Pilar La muerte de c\u00e9lulas tubulares es el \u00fanico par\u00e1metro histol\u00f3gico que se correlaciona [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[1],"tags":[36958,81602,81601,81600,81599,2097],"class_list":["post-28710","post","type-post","status-publish","format-standard","hentry","category-sin-categoria","tag-alberto-ortiz-arduan","tag-alberto-tejedor","tag-fernando-liano","tag-francisco-mampaso","tag-justo-diaz-m-pilar","tag-manuel-oya-otero"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/28710","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=28710"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/28710\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=28710"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=28710"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=28710"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}