{"id":28764,"date":"2018-03-09T09:21:36","date_gmt":"2018-03-09T09:21:36","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/caracterizacion-del-papel-y-mecanismos-de-accion-de-ghrelina-en-el-control-de-la-funcion-testicular\/"},"modified":"2018-03-09T09:21:36","modified_gmt":"2018-03-09T09:21:36","slug":"caracterizacion-del-papel-y-mecanismos-de-accion-de-ghrelina-en-el-control-de-la-funcion-testicular","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/cordoba\/caracterizacion-del-papel-y-mecanismos-de-accion-de-ghrelina-en-el-control-de-la-funcion-testicular\/","title":{"rendered":"Caracterizaci\u00f3n del papel y mecanismos de acci\u00f3n de ghrelina en el control de la funci\u00f3n testicular"},"content":{"rendered":"<h2>Tesis doctoral de <strong> M. Luz Barreiro Arca <\/strong><\/h2>\n<p>La ghrelina, es un p\u00e9ptido de 28 amino\u00e1cidos sintetizado principalmente en el est\u00f3mago e implicado en el control de la secrecci\u00f3n de gh y la ingesta de alimentos. Distintas evidencias experimentales han abierto la posibilidad de que la hormona tambi\u00e9n est\u00e9 implicada en el control de la funci\u00f3n reproductora. en esta tesis se llev\u00f3 a cabo un an\u00e1lisis exhaustivo de la expresi\u00f3n de la ghrelina y su receptor en el test\u00edculo de rata y tambi\u00e9n se estudiaron las posibles acciones biol\u00f3gicas de la hormona en este tejido. Asimismo, se inici\u00f3 el an\u00e1lisis de la expresi\u00f3n de la ghrelina y su receptor en otros tejidos esteroidog\u00e9nicos: la gl\u00e1ncula adrenal y el ovario de rata, ovario y test\u00edculo humanos.  la ghrelina se expresa en el test\u00edculo de rata a lo largo del desarrollo postnatal. \u00e9Sta se localiza slectivamente en las c\u00e9lulas leydig, del intersticio testicular, siendo m\u00e1xima su expresi\u00f3n en las c\u00e9lulas de leydig maduras tanto fetales como adultas, y dicha expresi\u00f3n est\u00e1 regulada por la lh hipofisaria. el receptor de ghrelina, el ghs-r, se expresa en el test\u00edculo de rata a lo largo del desarrollo postnatal. Sin embargo, el arnm que codifica la forma funcional del receptor, ghsr-1a, se expresa s\u00f3lo a partir del periodo prepuberal.  La expresi\u00f3n de ghs-r 1a es detectable en diversos tipos celulares testiculares (c\u00e9luas de leydig, c\u00e9lulas de sertoli y probablemente c\u00e9lulas germinales) y es regulada por la propia ghrelina y la fsh hipofisaria. la ghrelina inhibe la secreci\u00f3n estimulada de testosterona y la expresi\u00f3n de genes que codifican etapas clave en la ruta esteriodog\u00e9nica (star, p450scc. 3beta-hsd, 17beta-hsd). Igualmente, la ghrelina inhibe la expresi\u00f3n del gen de scf, factor espec\u00edfico de las c\u00e9lulas de sertoli del test\u00edculo con un papel relevante en el control de la espermatog\u00e9nesis.  el receptor  ghs-r se expresa igualmente en la gl\u00e1ndula adrenal de rata, siendo \u00e9sta regulada por su ligando. No obst<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Caracterizaci\u00f3n del papel y mecanismos de acci\u00f3n de ghrelina en el control de la funci\u00f3n testicular<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Caracterizaci\u00f3n del papel y mecanismos de acci\u00f3n de ghrelina en el control de la funci\u00f3n testicular <\/li>\n<li><strong>Autor:<\/strong>\u00a0 M. Luz Barreiro Arca <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 C\u00f3rdoba<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 20\/02\/2004<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Manuel Jose Tena Sempere<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal:  S\u00e1nchez criado Jos\u00e9 eugenio <\/li>\n<li>Carlos Dieguez gonzalez (vocal)<\/li>\n<li>Francisco Gaytan luna (vocal)<\/li>\n<li>jorma Toppari (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de M. Luz Barreiro Arca La ghrelina, es un p\u00e9ptido de 28 amino\u00e1cidos sintetizado principalmente en el est\u00f3mago [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[973],"tags":[15487,20999,81743,81741,81742,2379],"class_list":["post-28764","post","type-post","status-publish","format-standard","hentry","category-cordoba","tag-carlos-dieguez-gonzalez","tag-francisco-gaytan-luna","tag-jorma-toppari","tag-m-luz-barreiro-arca","tag-manuel-jose-tena-sempere","tag-sanchez-criado-jose-eugenio"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/28764","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=28764"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/28764\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=28764"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=28764"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=28764"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}