{"id":28816,"date":"2018-03-09T09:21:40","date_gmt":"2018-03-09T09:21:40","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-del-comportamiento-molecular-y-cla%c2%adnico-del-gen-brca1-en-cancer-de-colon\/"},"modified":"2018-03-09T09:21:40","modified_gmt":"2018-03-09T09:21:40","slug":"estudio-del-comportamiento-molecular-y-cla%c2%adnico-del-gen-brca1-en-cancer-de-colon","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-del-comportamiento-molecular-y-cla%c2%adnico-del-gen-brca1-en-cancer-de-colon\/","title":{"rendered":"Estudio del comportamiento molecular y cl\u00ednico del gen brca1 en c\u00e1ncer de colon"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Jos\u00e9 Miguel Garc\u00eda Ruiz <\/strong><\/h2>\n<p>El c\u00e1ncer colorrectal (cc) constituye aproximadamente el 15% de los tumores diagnosticados en el hombre. Existen una serie de factores de riesgo bien establecidos, como son: edad superior a 40 a\u00f1os, existencia de adenomas previos, colitis ulcerosa, colitis granulomatosa y predisposici\u00f3n gen\u00e9tica, aunque aproximadamente el 90% de los casos de cc son espor\u00e1dicos. El 10% restante son hereditarios, present\u00e1ndose bajo dos formas bien caracterizadas, poliposis adenomatosa familiar y c\u00e1ncer hereditario no polip\u00f3sico, aunque existen otros s\u00edndromes que incluyen entre sus caracater\u00edsticas el desarrollo de cc, as\u00ed en estudios epidemiol\u00f3gicos se observ\u00f3 mayor incidencia de cc en familias relacionadas con el gen brca1. Este gen codifica una prote\u00edna multidominio de 1863 amino\u00e1cidos que aparece involucrada en una gran cantidad de procesos celulares como son: mantenimiento de la integridad gen\u00f3mica, control del ciclo celular, duplicaci\u00f3n de los centrosomas, regulaci\u00f3n transcripcional, regulaci\u00f3n de la proliferaci\u00f3n celular y remodelaci\u00f3n de la cromatina.  en el presente trabajo hemos estudiado la frecuencia de p\u00e9rdidas al\u00e9licas en el locus de brca1 en una serie de pacientes diagnosticados de cc y su valor como factor pron\u00f3stico de la enfermedad. El 39.8% de los pacientes presentaban p\u00e9rdidas de heterocigosidad (loh) en el locus de brca1, siendo la frecuencia de reca\u00eddas en este grupo significativamente mayor que en el grupo sin loh (p=0,0003). De la misma manera la superviviencia libre de enfermedad fue significativamente mayor entre los pacientes sin loh (p=0,0004), resultados que se manten\u00edan en estad\u00edos i (p=0.03) y ii (p=0.001). la presencia de loh tambi\u00e9n se asoci\u00f3 con una menor supervivencia global (p=0.02). El an\u00e1lisis multivariante en la serie completa mostr\u00f3 que el estad\u00edo y la afectaci\u00f3n ganglionar eran factores pron\u00f3sticos independientes, sin embargo el estudio por estad\u00edos revel\u00f3 que la loh en brca1 era un<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio del comportamiento molecular y cl\u00ednico del gen brca1 en c\u00e1ncer de colon<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio del comportamiento molecular y cl\u00ednico del gen brca1 en c\u00e1ncer de colon <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Jos\u00e9 Miguel Garc\u00eda Ruiz <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 23\/02\/2004<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Felix Bonilla Velasco<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: valent\u00edn Cuervas-mons mart\u00ednez <\/li>\n<li>Antonio Colas vicente (vocal)<\/li>\n<li>Santiago Coca menchero (vocal)<\/li>\n<li>Antonio Colmenarejo rubio (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Jos\u00e9 Miguel Garc\u00eda Ruiz El c\u00e1ncer colorrectal (cc) constituye aproximadamente el 15% de los tumores diagnosticados en [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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