{"id":2882,"date":"1994-01-01T00:00:00","date_gmt":"1994-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/1994\/01\/01\/biodisponibilidad-oral-de-la-amiodarona-en-la-rata\/"},"modified":"1994-01-01T00:00:00","modified_gmt":"1994-01-01T00:00:00","slug":"biodisponibilidad-oral-de-la-amiodarona-en-la-rata","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/biodisponibilidad-oral-de-la-amiodarona-en-la-rata\/","title":{"rendered":"\u00abbiodisponibilidad oral de la amiodarona en la rata\u00bb"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Pascual Costa Rosa M. <\/strong><\/h2>\n<p>La amiodarona es un farmaco antiarritmico y antianginoso de amplia difusion en la practica clinica, presenta gran variabilidad tanto intra como interindividual en la respuesta farmacologica. En la presente memoria, se ha determinado la biodisponibilidad oral de la amiodarona a partir de varias formas de administracion: comprimido comercial, solucion inyectable comercial y solucion de amiodarona (5 mg\/ml) en polisorbato 80 al 5%. Los ensayos se han realizado tras la administracion de una dosis unica y tras la administracion de dos dosis de farmaco.  para ello, se ha procedido a la implantacion de un cateter, de forma permanente, en la vena yugular con objeto de proceder a la administracion del farmaco por via intravenosa asi como facilitar la toma de muestras plasmaticas en los tiempos preestablecidos. La valoracion de las muestras plasmaticas se ha realizado por cromatografia liquida de alta eficacia. Se han ajustado los modelos compartimentales y no compartimentales a los valores experimentales obtenidos. De esta forma se han calculado los parametros farmacocineticos de la amiodarona en la rata y se ha determinado la biodisponibilidad oral de cada uno de los preparados ensayados.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>\u00abbiodisponibilidad oral de la amiodarona en la rata\u00bb<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 \u00abbiodisponibilidad oral de la amiodarona en la rata\u00bb <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Pascual Costa Rosa M. <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Universitat de val\u00e9ncia (estudi general)<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1994<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Casabo Alos Vicente G.<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal:  Pla Delfina  Jos\u00e9 M <\/li>\n<li> Garcia Sanchez M. Jos\u00e9 (vocal)<\/li>\n<li>Ram\u00f3n Mart\u00ednez Pacheco (vocal)<\/li>\n<li>Julio Cortijo Gimeno (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Pascual Costa Rosa M. La amiodarona es un farmaco antiarritmico y antianginoso de amplia difusion en la [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[9481,9,189],"tags":[12190,3756,12191,12189,11483,3307],"class_list":["post-2882","post","type-post","status-publish","format-standard","hentry","category-absorcion-de-los-farmacos","category-ciencias-medicas","category-farmacodinamia","tag-casabo-alos-vicente-g","tag-garcia-sanchez-m-jose","tag-julio-cortijo-gimeno","tag-pascual-costa-rosa-m","tag-pla-delfina-jose-m","tag-ramon-Martinez-pacheco"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/2882","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=2882"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/2882\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=2882"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=2882"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=2882"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}