{"id":28836,"date":"2018-03-09T09:21:42","date_gmt":"2018-03-09T09:21:42","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/inhibicion-de-la-adhesion-de-candida-albicans-a-celulas-orales-mediante-el-uso-de-anticuerpos-monoclonales\/"},"modified":"2018-03-09T09:21:42","modified_gmt":"2018-03-09T09:21:42","slug":"inhibicion-de-la-adhesion-de-candida-albicans-a-celulas-orales-mediante-el-uso-de-anticuerpos-monoclonales","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/pais-vasco-euskal-herriko-unibertsitatea\/inhibicion-de-la-adhesion-de-candida-albicans-a-celulas-orales-mediante-el-uso-de-anticuerpos-monoclonales\/","title":{"rendered":"Inhibici\u00f3n de la adhesi\u00f3n de candida albicans a c\u00e9lulas orales mediante el uso de anticuerpos monoclonales"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Elguezabal Vega Natalia M. <\/strong><\/h2>\n<p>Candida albicans es la especie m\u00e1s representativa y ampliamente estudiada del g\u00e9nero candida. Se trata de un hongo dim\u00f3rfico, pat\u00f3geno oportunista, comensal com\u00fan de mucosas oral, gastrointestinal y genital de individuos sanos. Su transici\u00f3n de comensal a pat\u00f3geno se ve facilitada en el caso de pacientes que reciben terapias inmunosupresoras, presentan inmunodeficiencias o en individuos muy j\u00f3venes o ancianos. Para efectuar dicha transici\u00f3n c. Albicans dispone de diferentes factores virulencia, como son, la transici\u00f3n blastospora-micelio, la variabilidad antig\u00e9nica, al cambio fenot\u00edpico, la adhesi\u00f3n, la hidrofobicidad superficial, el mimetismo molecular y la producci\u00f3n de enzimas extracelulares. Entre estos factores, la adhesi\u00f3n representa un papel cr\u00edtico pues el paso inicial y esencial previo a la colonizaci\u00f3n.  la candidiasis oral es de especial importancia en individuos vih+ y en portadores de pr\u00f3tesis dentales. Debido a que la adhesi\u00f3n se considera la primera etapa en la colonizaci\u00f3n por c. Albicans resulta interesante el desarrollo de f\u00e1rmacos que puedan bloquear este proceso. La administraci\u00f3n de anticuerpos monoclonales que imiten las actividades anti-candida que posee la iga secretora de la saliva podr\u00eda ser utilizada como medida terap\u00e9utica para prevenir el desarrollo de la candidiasis oral. En este trabajo se ha estudiado el efecto la saliva y de diversos anticuerpos monoclonales dirigidos contra mol\u00e9culas de la superficie de candida sobre la adhesi\u00f3n de c. Albicans a c\u00e9lulas epiteliales orales, resinas restauradoras dentales y resinas empleadas para la fabricaci\u00f3n de pr\u00f3tesis dentales. Se ha observado que mediante las distintas actividades que presentan los anticuerpos monoclonales y que son compartidas por algunos componentes de la saliva, como la aglutinaci\u00f3n, la inhibici\u00f3n de la adhesi\u00f3n, inhibici\u00f3n de la filamentaci\u00f3n o incluso la muerte celular directa, se puede disminuir y de alguna man<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Inhibici\u00f3n de la adhesi\u00f3n de candida albicans a c\u00e9lulas orales mediante el uso de anticuerpos monoclonales<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Inhibici\u00f3n de la adhesi\u00f3n de candida albicans a c\u00e9lulas orales mediante el uso de anticuerpos monoclonales <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Elguezabal Vega Natalia M. <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Pa\u00eds vasco\/euskal herriko unibertsitatea<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 25\/02\/2004<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Pont\u00f3n San Emeterio Jose<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: guillermo Quind\u00f3s andr\u00e9s <\/li>\n<li>Jos\u00e9 Schneider fontan (vocal)<\/li>\n<li>Carlos Matute almau (vocal)<\/li>\n<li>Ana Mar\u00eda Castillo perez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Elguezabal Vega Natalia M. Candida albicans es la especie m\u00e1s representativa y ampliamente estudiada del g\u00e9nero candida. [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[12909],"tags":[81891,10024,81890,13560,13001,5149],"class_list":["post-28836","post","type-post","status-publish","format-standard","hentry","category-pais-vasco-euskal-herriko-unibertsitatea","tag-ana-maria-castillo-perez","tag-carlos-matute-almau","tag-elguezabal-vega-natalia-m","tag-guillermo-quindos-andres","tag-jose-schneider-fontan","tag-ponton-san-emeterio-jose"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/28836","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=28836"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/28836\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=28836"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=28836"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=28836"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}