{"id":28888,"date":"2018-03-09T09:21:46","date_gmt":"2018-03-09T09:21:46","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/influencia-genetica-de-las-moleculas-de-histocompatibilidad-de-clase-ii-en-la-expresion-del-dano-hepatico-en-la-hepatotoxicidad-idiosincrasica-debida-a-farmacos\/"},"modified":"2018-03-09T09:21:46","modified_gmt":"2018-03-09T09:21:46","slug":"influencia-genetica-de-las-moleculas-de-histocompatibilidad-de-clase-ii-en-la-expresion-del-dano-hepatico-en-la-hepatotoxicidad-idiosincrasica-debida-a-farmacos","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/malaga\/influencia-genetica-de-las-moleculas-de-histocompatibilidad-de-clase-ii-en-la-expresion-del-dano-hepatico-en-la-hepatotoxicidad-idiosincrasica-debida-a-farmacos\/","title":{"rendered":"Influencia genetica de las moleculas de histocompatibilidad de clase ii en la expresion del da\u00f1o hepatico en la hepatotoxicidad idiosincrasica debida a farmacos."},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Alonso Diaz Ana Isabel <\/strong><\/h2>\n<p>Introducci\u00f3n y objetivo: la hepatotoxicidad idiosincr\u00e1nica inducida por f\u00e1rmacos depende en gran medida de la susceptibilidad del hu\u00e9sped. La influencia gen\u00e9tica de las mol\u00e9culas de histocompatibilidad de clase ii en la predisposici\u00f3n a desarrollar dicha hepatotoxicidad ha sido defendida en diversos estudios. se buscaron asociaciones entre los alelos hla drb y dqb y el desarrollo de hepatotoxicidad idiosincr\u00e1sica inducida por f\u00e1rmacos.  m\u00e9todos: se estudiaron un total de 140 pacientes con diagnostico definitivo o probable de hepatotoxicidad idiosincr\u00e1sica inducida por f\u00e1rmacos, de acuerdo con la escala cioms, frente a 635 donantes voluntarios de m\u00e9dula \u00f3sea y sangre como controles. El genotipage del hla dbr1* y dqb1* fue hecho mediante hibridaci\u00f3n y secuenciaci\u00f3n espec\u00edfica de oligonucle\u00f3tidos tras amplificaci\u00f3n gen\u00f3mica. Resutados: el grupo con hepatotoxicidad idiosincr\u00e1sica inducida por f\u00e1rmacos no fue diferente del grupo control en relaci\u00f3n con la distribuci\u00f3n de los ant\u00edgenos hla drb y dqb. La frecuencia de los alelos drb1*15 (35.4% vs 18.6% del control; p= 0.002; or=2.31) se incrementaron significativamente en los pacientes con da\u00f1o hep\u00e1tico tipo colest\u00e1tico\/mixto en comparaci\u00f3n con los sujetos sanos. Por el contrario la frecuencia de los alelos drb1*07 (16,9% vs 35.4%; p=0.0003; or=0.37%) y dqb1*02 (32.2% vs 55.8%; p=0.0003; or= 0.39) descendieron significativamente. Conclusi\u00f3n: no existe asociaci\u00f3n entre el alelo espec\u00edfico hla y la predisposici\u00f3n a desarrollar hepatotoxicidad idiosincr\u00e1sica inducida por f\u00e1rmacos. La influencia gen\u00e9tica asociada con el hla de clase ii parece desempe\u00f1ar su papel en la expresi\u00f3n bioqu\u00edmica del da\u00f1o hep\u00e1tico en la hepatotoxicidad, y podr\u00eda explicar por qu\u00e9 el f\u00e1rmaco administrado causar\u00eda diferentes patrones de da\u00f1o hep\u00e1tico.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Influencia genetica de las moleculas de histocompatibilidad de clase ii en la expresion del da\u00f1o hepatico en la hepatotoxicidad idiosincrasica debida a farmacos.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Influencia genetica de las moleculas de histocompatibilidad de clase ii en la expresion del da\u00f1o hepatico en la hepatotoxicidad idiosincrasica debida a farmacos. <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Alonso Diaz Ana Isabel <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 M\u00e1laga<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 27\/02\/2004<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>M Isabel Lucena Gonzalez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jes\u00fas m. Prieto valtue\u00f1a <\/li>\n<li>joan Costa pag\u00e9s (vocal)<\/li>\n<li>dolores Montero corominas (vocal)<\/li>\n<li>raquel Camargo camero (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Alonso Diaz Ana Isabel Introducci\u00f3n y objetivo: la hepatotoxicidad idiosincr\u00e1nica inducida por f\u00e1rmacos depende en gran medida [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[7834],"tags":[82011,82012,15059,58687,4062,82013],"class_list":["post-28888","post","type-post","status-publish","format-standard","hentry","category-malaga","tag-alonso-diaz-ana-isabel","tag-dolores-montero-corominas","tag-jesus-m-prieto-valtuena","tag-joan-costa-pages","tag-m-isabel-lucena-gonzalez","tag-raquel-camargo-camero"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/28888","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=28888"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/28888\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=28888"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=28888"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=28888"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}