{"id":28922,"date":"2018-03-09T09:21:49","date_gmt":"2018-03-09T09:21:49","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/papel-del-activador-tisular-del-plasminogeno-tpa-en-el-desarrollo-y-progresion-tumoral\/"},"modified":"2018-03-09T09:21:49","modified_gmt":"2018-03-09T09:21:49","slug":"papel-del-activador-tisular-del-plasminogeno-tpa-en-el-desarrollo-y-progresion-tumoral","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/pompeu-fabra\/papel-del-activador-tisular-del-plasminogeno-tpa-en-el-desarrollo-y-progresion-tumoral\/","title":{"rendered":"Papel del activador tisular del plasminogeno (tpa) en el desarrollo y progresi\u00f3n tumoral"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Susana Aguilar Izquierdo <\/strong><\/h2>\n<p>El c\u00e1ncer de p\u00e1ncreas es la quinta causa de muerte en el mundo occidental y uno de los tumores m\u00e1s agresivos. El sistema del plasmin\u00f3geno es importante en la tromb\u00f3lisis intravascular y en procesos biol\u00f3gicos que requieren la migraci\u00f3n celular como la angiog\u00e9nesis y la progresi\u00f3n tumoral.  la activaci\u00f3n del plasmin\u00f3geno, mediada por el activador tisular del plasmin\u00f3geno (tpa) y el activador del plasmin\u00f3geno de tipo uroquinasa (upa), resulta en la degradaci\u00f3n de prote\u00ednas de la matriz extracelular y la activaci\u00f3n de mmps y factores de crecimiento latentes.  el objetivo de esta tesis ha sido estudiar el papel del tpa  en la progresi\u00f3n tumoral in vivo mediante el uso de modelos murinos de c\u00e1ncer de p\u00e1ncreas y analizar su mecanismo de acci\u00f3n. Como modelo de tumorig\u00e9nesis pancre\u00e1tica se utilizaron los animale stransg\u00e9ncios ela1-tag y ela1-myc. Asimismo se utilizaron los animales transg\u00e9nicos ela1-cck2 y mt-tgf-a, como modelo de metaplasia acinar-ductal.  los resultados muestran que tpa no se detecta en ning\u00fan tipo celular epitelial en el p\u00e1ncreas normal ni en ductos metapl\u00e1sicos ni en c\u00e9lulas acinares tumorales, encontr\u00e1ndose sobreexpresado en los duxtos neopl\u00e1sicos pancre\u00e1ticos. por otro lado, anexina a2 se detecta en el dominio apical del epitelio de ductos normales y complejos ductales y se encuentra sobreexpresada y despolarizada en los ductos neopl\u00e1sicos.  con el fin de determinar el efecto de la inactivaci\u00f3n del tpa al desarrollo de los tumores de los ratones ela1-myc se cruzaron estos animales transg\u00e9nicos con ratones knock out para tpa (tpa-\/-). Los ratones h\u00edbridos ela1-myc;tpa-\/- tambi\u00e9n desarrollan tumores pancre\u00e1ticos y la proporci\u00f3n de tumores con componente ductal no se modifica. Sin embargo, se observ\u00f3 un incremento de la supervivencia en los animales que no expresan tpa, indicando que esta proteasas favorece la progresi\u00f3n del tumor. El an\u00e1lisis de factores relacionados con progresi\u00f3n<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Papel del activador tisular del plasminogeno (tpa) en el desarrollo y progresi\u00f3n tumoral<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Papel del activador tisular del plasminogeno (tpa) en el desarrollo y progresi\u00f3n tumoral <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Susana Aguilar Izquierdo <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Pompeu fabra<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 27\/02\/2004<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Pilar Navarro Medrano<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: purificacion Mu\u00f1oz canoves <\/li>\n<li>Miguel Quintanilla avila (vocal)<\/li>\n<li>cristina Fillat fons (vocal)<\/li>\n<li>jaume Pulats xanco (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Susana Aguilar Izquierdo El c\u00e1ncer de p\u00e1ncreas es la quinta causa de muerte en el mundo occidental [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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