{"id":28951,"date":"2004-02-03T00:00:00","date_gmt":"2004-02-03T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/deteccion-de-carbapenemasas-e-identificacion-del-nuevo-enzima-oxa-40-en-clones-de-acinetobacter-baumannii-resistentes-a-imipenem\/"},"modified":"2004-02-03T00:00:00","modified_gmt":"2004-02-03T00:00:00","slug":"deteccion-de-carbapenemasas-e-identificacion-del-nuevo-enzima-oxa-40-en-clones-de-acinetobacter-baumannii-resistentes-a-imipenem","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/pais-vasco-euskal-herriko-unibertsitatea\/deteccion-de-carbapenemasas-e-identificacion-del-nuevo-enzima-oxa-40-en-clones-de-acinetobacter-baumannii-resistentes-a-imipenem\/","title":{"rendered":"Detecci\u00f3n de carbapenemasas e identificaci\u00f3n del nuevo enzima oxa-40 en clones de acinetobacter baumannii resistentes a imipenem."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Fernando Lopitz Otsoa <\/strong><\/h2>\n<p>Durante los \u00faltimos a\u00f1os se ha observado un incremento, tanto en el detecci\u00f3n de aislamientos de acinetobacter baumannii implicados en infecciones nosocomiales, como en la resistencia antibi\u00f3tica mostrada por estos aislamientos. Esta resistencia se da incluso frente a imipenem, que es el antibi\u00f3tico de elecci\u00f3n, de manera que las infecciones producidas por estos microorganismos resultan muy dif\u00edciles de tratrar. Entre los diferentes mecanismos de resistencia a los carbapenemas, uno de los m\u00e1s importantes ser\u00eda la producci\u00f3n de carbapenemasas, cuya diseminaci\u00f3n puede esta asociada a la presencia de estructuras gen\u00e9ticas m\u00f3viles, denominadas integrones.  en este trabajo se ha estudiado la poblaci\u00f3n de acinetobacter baumannil resitente a imipenem, del hospital de santa marina en bilbao. Se ha desarrollado una metodolog\u00eda basada en la reacci\u00f3n en cadena de la polimerasa (pcr), para caracterizar gen\u00e9ticamente las agrupaciones clonales presentes en el hospital de santa marina, seleccion\u00e1ndose los iniciadores ap3 y eric2, como los m\u00e1s apropiados, que permiti\u00f3 identificar once agrupaciones clonales, detectando cuatro genotipos predominantes, siendo mayoritario el denominado clon ii, que agrupaba el 61% de los aislamientos resistentes a imipenem.  el 32,89% de los aislamientos resistentes a imipenem portaba pl\u00e1smidos, en un rango que iba desde 180 a 1,3 kb. Se ha constatado la elevada presencia de integrones de clase i. Se ha detectado a nivel fenot\u00edpico la presencia de carbapenemasas en el 75% de los aislamientos analizados distribuy\u00e9ndose estos, en todos los genotipos detectados, lo que implicar\u00eda una amplia presencia de este tipo de enzimas en los clones analizados.  se ha identificado una nueva carbapenemasa, denominada oxa-40, que es una b-lactamasa de clase d relacionada con una similutud del 98%, con la familia oxa-24, oxa-25 y oxa-26 descritas en Madrid, murcia y gante (b\u00e9lgica) y que est\u00e1 presente en dos de los<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Detecci\u00f3n de carbapenemasas e identificaci\u00f3n del nuevo enzima oxa-40 en clones de acinetobacter baumannii resistentes a imipenem.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Detecci\u00f3n de carbapenemasas e identificaci\u00f3n del nuevo enzima oxa-40 en clones de acinetobacter baumannii resistentes a imipenem. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Fernando Lopitz Otsoa <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Pa\u00eds vasco\/euskal herriko unibertsitatea<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 02\/03\/2004<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Luc\u00eda Gallego Andr\u00e9s<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: ramon Cisterna cancer <\/li>\n<li>katrina Levi (vocal)<\/li>\n<li>j. Towner kevin (vocal)<\/li>\n<li>Juan Garc\u00eda lobo (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Fernando Lopitz Otsoa Durante los \u00faltimos a\u00f1os se ha observado un incremento, tanto en el detecci\u00f3n de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[12909],"tags":[82162,82164,10662,82163,32107,5148],"class_list":["post-28951","post","type-post","status-publish","format-standard","hentry","category-pais-vasco-euskal-herriko-unibertsitatea","tag-fernando-lopitz-otsoa","tag-j-towner-kevin","tag-juan-garcia-lobo","tag-katrina-levi","tag-lucia-gallego-andres","tag-ramon-cisterna-cancer"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/28951","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=28951"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/28951\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=28951"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=28951"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=28951"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}