{"id":28963,"date":"2004-03-03T00:00:00","date_gmt":"2004-03-03T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/efecto-de-factores-nutricionales-y-ambientales-en-celulas-de-adenocarcinoma-de-colon-humano\/"},"modified":"2004-03-03T00:00:00","modified_gmt":"2004-03-03T00:00:00","slug":"efecto-de-factores-nutricionales-y-ambientales-en-celulas-de-adenocarcinoma-de-colon-humano","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/efecto-de-factores-nutricionales-y-ambientales-en-celulas-de-adenocarcinoma-de-colon-humano\/","title":{"rendered":"Efecto de factores nutricionales y ambientales en c\u00e9lulas de adenocarcinoma de colon humano"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Pablo P\u00e9rez Ramos <\/strong><\/h2>\n<p>El balance entre los procesos de proliferaci\u00f3n, diferenciaci\u00f3n y apoptosis es clave en la tumorig\u00e9nesis colorrectal, siendo la dieta uno de los factores que pueden alterarlo.  as\u00ed, por un lado, la ingesta de grasas se ha relacionado con un aumento en la descarga de \u00e1cidos biliares en el intestino y un aumento en la formaci\u00f3n de tumores. Por otra parte, las dietas ricas en fibra aumentan la concentraci\u00f3n intracol\u00f3nica de butiraro, nutriente que juega un papel relevante en la renovaci\u00f3n del epitelio intestinal.  las c\u00e9lulas de adenocarcinoma de colon bcs-tc2 y bcs-tc2. Br2 constituyen un modelo adecuado para estudiar el efecto del butirato y de los \u00e1cidos biliares. El efecto ejercido por los \u00e1cidos biliares es dependiente de su estructura tridimensional. El dca, cdca y lca inducen muerte celular por apoptosis. As\u00ed, provocan la activaci\u00f3n de caspasa-3 y -9 implicadas en la v\u00eda mitocondrial. Los efectos de estos agentes son menos acusados en las c\u00e9lulas bcs-tc2. Br2 resistentes a la apoptosis inducida por butirato.  otro inhibidor de la desacetilaci\u00f3n de histonas, como el buitraro, es la tsa. Este agente induce muerte celular en ambas l\u00edneas celulares. Por tanto, la resistencia al efecto del butirato ser\u00e1 consecuencia de alteraciones en el transporte y\/o metabolizaci\u00f3n de dicho \u00e1cido graso.  aunque el butirato, la tsa y los \u00e1cidos biliares inducen apoptosis en las c\u00e9lulas, sin embargo ejercen efectos distintos en el comportamiento celular. as\u00ed provocan diferentes alteraciones en el grado de diferenciaci\u00f3n celular, en la capacidad migratoria de las c\u00e9lulas y en la expresi\u00f3n de prote\u00ednas tales como hsp-72, p53, p21 y pkc*, lo que podr\u00eda estar relacionado con el papel antag\u00f3nico descrito in vivo para estos agentes.  ambas l\u00edneas celulares presentan diferencias en cuanto a su capaciad de adhesi\u00f3n a componentes de la matriz extracelular y de desadhesi\u00f3n del sustrato, lo que puede estar relacionado con sus difer<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Efecto de factores nutricionales y ambientales en c\u00e9lulas de adenocarcinoma de colon humano<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Efecto de factores nutricionales y ambientales en c\u00e9lulas de adenocarcinoma de colon humano <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Pablo P\u00e9rez Ramos <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 03\/03\/2004<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Mar\u00eda  Antonia Lizarbe  Iracheta<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: felic\u00edsima Mata andr\u00e9s <\/li>\n<li>julia Bujan varela (vocal)<\/li>\n<li>Mar\u00eda  dolores Blanco gaitan (vocal)<\/li>\n<li>eduardo Jorge guerrero (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Pablo P\u00e9rez Ramos El balance entre los procesos de proliferaci\u00f3n, diferenciaci\u00f3n y apoptosis es clave en la [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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