{"id":28977,"date":"2004-04-03T00:00:00","date_gmt":"2004-04-03T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/caracterizacion-de-una-nueva-toxima-producida-por-pseudomonas-syringae-pv-syringae-mangotoxina-biosintesis-y-papel-en-la-patogenesis\/"},"modified":"2004-04-03T00:00:00","modified_gmt":"2004-04-03T00:00:00","slug":"caracterizacion-de-una-nueva-toxima-producida-por-pseudomonas-syringae-pv-syringae-mangotoxina-biosintesis-y-papel-en-la-patogenesis","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/malaga\/caracterizacion-de-una-nueva-toxima-producida-por-pseudomonas-syringae-pv-syringae-mangotoxina-biosintesis-y-papel-en-la-patogenesis\/","title":{"rendered":"Caracterizaci\u00f3n de una nueva t\u00f3xima producida por pseudomonas syringae pv. syringae: mangotoxina. biosintesis y papel en la patog\u00e9nesis"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Eva Mar\u00eda Arrebola Diez <\/strong><\/h2>\n<p>Pseudomonas syringae pv. Syringae es una bacteria frecuentemente aislada de numerosas plantas y el agente causal de la necrosis apical del mango. la toxina antimetabolito producida por cepas de p. Syringae pv. Syringae y denominada mangotoxina, se detect\u00f3 mediante el ensayo de inhibici\u00f3n del crecimiento de escherichia coli, inhibici\u00f3n que revert\u00eda en presencia de l-ornitina, pero no de n-acetil ornitina, por lo que se pod\u00eda deducir que afectaba a la ruta de s\u00edntesis de ornitina\/arginina. Filtrados libres de c\u00e9lulas de cepas productoras de mangotoxina provocan una fuerte disminuci\u00f3n de la actividad ornitina acetiltransferasa (oat) en extractos proteicos de foliolos de tomate, lo que confirma  a dicha enzima como diana de esta toxina. Diferentes tratamientos fisico-qu\u00edmicos sugieren la mangotoxina es un oligop\u00e9ptido hidrofilico sin una estructura secundaria compleja (sensible a proteasas, pero estable a altas temperaturas y ph estremos) como otras toxinas antimetabolito, tales como tabtoxina y  faselotoxina. Mediante hplc, la actividad de la mangotoxina se asoci\u00f3 a un \u00fanico pico presente en filtrados libres de c\u00e9lulas de una cepa productora, y que no se detecta en los de una cepa mutante defectiva en la producci\u00f3n de la toxina.  para el an\u00e1lisis de los genes implicados en producci\u00f3n de mangotoxina en la cepa umaf0158 de pseudomonas syringgae pv, syringae se construyeron mutantes defectivos en la producci\u00f3n de esta toxina. El estudio de las secuencias nucleot\u00eddicas de los genes mutagenizados mostraron, en un primer acercamiento, homolog\u00edas con genes de regulaci\u00f3n bacteriana como gaca y lema, con una p\u00e9ptidosintasa no ribosomal, con una acetiltransferasa y con una tiorredoxina\/lipoprote\u00edna, entre otros. Un an\u00e1lisis m\u00e1s exhaustivo de la regi\u00f3n gen\u00f3mica clonada en pcg2-6 y que restauraba la producci\u00f3n de mangotoxina en el mutante defectivo en la producci\u00f3n de mangotoxina umaf0158-6yf6, mostr\u00f3 que una p\u00e9ptidosintasa<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Caracterizaci\u00f3n de una nueva t\u00f3xima producida por pseudomonas syringae pv. syringae: mangotoxina. biosintesis y papel en la patog\u00e9nesis<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Caracterizaci\u00f3n de una nueva t\u00f3xima producida por pseudomonas syringae pv. syringae: mangotoxina. biosintesis y papel en la patog\u00e9nesis <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Eva Mar\u00eda Arrebola Diez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 M\u00e1laga<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 04\/03\/2004<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Antonio De Vicente Moreno<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: francisca Mar\u00eda Sanchez jimenez <\/li>\n<li>Jes\u00fas Murillo Martinez (vocal)<\/li>\n<li>Juan  Luis Ramos martin (vocal)<\/li>\n<li>pablo Rodr\u00edguez palenzuela (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Eva Mar\u00eda Arrebola Diez Pseudomonas syringae pv. Syringae es una bacteria frecuentemente aislada de numerosas plantas y [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[7834],"tags":[38252,82217,41389,38251,3634,48073],"class_list":["post-28977","post","type-post","status-publish","format-standard","hentry","category-malaga","tag-antonio-de-vicente-moreno","tag-eva-maria-arrebola-diez","tag-francisca-maria-sanchez-jimenez","tag-jesus-murillo-Martinez","tag-juan-luis-ramos-martin","tag-pablo-rodriguez-palenzuela"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/28977","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=28977"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/28977\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=28977"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=28977"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=28977"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}