{"id":29006,"date":"2004-05-03T00:00:00","date_gmt":"2004-05-03T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/mecanismos-de-neurodegeneracion-inducidos-por-el-la%c2%adquido-cefalorraqua%c2%addeo-en-la-esclerosis-multiple\/"},"modified":"2004-05-03T00:00:00","modified_gmt":"2004-05-03T00:00:00","slug":"mecanismos-de-neurodegeneracion-inducidos-por-el-la%c2%adquido-cefalorraqua%c2%addeo-en-la-esclerosis-multiple","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/mecanismos-de-neurodegeneracion-inducidos-por-el-la%c2%adquido-cefalorraqua%c2%addeo-en-la-esclerosis-multiple\/","title":{"rendered":"Mecanismos de neurodegeneraci\u00f3n inducidos por el l\u00edquido cefalorraqu\u00eddeo en la esclerosis m\u00faltiple"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Cristina Cid S\u00e1nchez <\/strong><\/h2>\n<p>La esclerosis m\u00faltiple (em) es una enfermedad autoinmune inflamatoria del sistema nervioso central (snc) y una de las causas m\u00e1s comunes de incapacidad neurol\u00f3gica en adultos j\u00f3venes. La enfermedad se caracteriza por la activaci\u00f3n del sistema inmunol\u00f3gico por causa desconocida con da\u00f1o inflamatorio de neuronas y oligodendrogl\u00eda, segudios por una recuperaci\u00f3n de la funci\u00f3n y reparaci\u00f3n estructural, gliosis postinflamatoria y neurodegeneraci\u00f3n. esta secuencia de procesos implica un curso cl\u00ednico caracterizado por episodios de recuperaci\u00f3n o remisiones, seguidos por el tiempo por nuevos episodios inflamatorios que suelen dejar secuelas persistentes, y con un progreso de la enfermedad. En el estudio de la em se pueden considerar tres aspectos fundamentales. En primer lugar, la desmielinizaci\u00f3n de los axones neuronales causada por la inflamaci\u00f3n del snc, en segundo lugar, la falta de remielinizaci\u00f3n que conduce a m\u00e1s largo plazo a la degeneraci\u00f3n de los axones desmielinizados, y por \u00faltimo, el da\u00f1o axonal en las neuronas. Tradicionalmente se han estudiado la inflamaci\u00f3n y desmielinizaci\u00f3n como causas primarias de la enfermedad. en este trabajo se ha abordado el estudio de los mecanismos de neurodegeneraci\u00f3n causada por la ausencia de remielinizaci\u00f3n y\/o por un da\u00f1o directo a las c\u00e9lulas neuronales, dos aspectos de la enfermedad poco conocidos y que han adquirido una gran importancia en los \u00faltimos a\u00f1os.  el estudio del da\u00f1o axonal primario se ha llevado a cabo con un modelo de cultivos neuronales embrionarios de rata tratados con l\u00edquido cefalorraqu\u00eddeo (lcr) de pacientes con em remitente-recurrente (rr). Nuestros datos demuestran que la neurotoxicidad inducida por el lcr de pacientes con em en cultivos neuronales est\u00e1 estrechamente correlacionada con la patolog\u00eda de los pacientes valorada mediatne su edds y sus lesiones en im\u00e1genes de resonancia magn\u00e9tica. as\u00ed, pacientes cuyo lcr induce  una mayor apoptosis<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Mecanismos de neurodegeneraci\u00f3n inducidos por el l\u00edquido cefalorraqu\u00eddeo en la esclerosis m\u00faltiple<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Mecanismos de neurodegeneraci\u00f3n inducidos por el l\u00edquido cefalorraqu\u00eddeo en la esclerosis m\u00faltiple <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Cristina Cid S\u00e1nchez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 05\/03\/2004<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Alberto Alc\u00e1zar Gonz\u00e1lez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal:  Mira portugal Mar\u00eda  teresa <\/li>\n<li>carmen Guaza rodriguez (vocal)<\/li>\n<li> Sierra p\u00e9rez Jos\u00e9 Manuel (vocal)<\/li>\n<li> Lopez-fando castro Juan  Jos\u00e9 (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Cristina Cid S\u00e1nchez La esclerosis m\u00faltiple (em) es una enfermedad autoinmune inflamatoria del sistema nervioso central (snc) [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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