{"id":29007,"date":"2004-05-03T00:00:00","date_gmt":"2004-05-03T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/regulacion-transcripcional-del-gen-de-rantes-ccl5-en-fibroblastos-dermicos-modulacion-a-traves-de-factores-pro-y-anti-inflamatorios\/"},"modified":"2004-05-03T00:00:00","modified_gmt":"2004-05-03T00:00:00","slug":"regulacion-transcripcional-del-gen-de-rantes-ccl5-en-fibroblastos-dermicos-modulacion-a-traves-de-factores-pro-y-anti-inflamatorios","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/regulacion-transcripcional-del-gen-de-rantes-ccl5-en-fibroblastos-dermicos-modulacion-a-traves-de-factores-pro-y-anti-inflamatorios\/","title":{"rendered":"Regulaci\u00f3n transcripcional del gen de rantes\/ccl5 en fibroblastos d\u00e9rmicos; modulaci\u00f3n a trav\u00e9s de factores pro- y anti-inflamatorios"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Vicente Arroyo Ana Bel\u00e9n <\/strong><\/h2>\n<p>La quimioquina rantes\/ccl5 es un potente quimioatrayente para diversas poblaciones leucocitarias. Los fibroblastos act\u00faan, al margen de su funci\u00f3n estructural dentro de los tejidos, como moduladores de la respuesta inmune mediante la expresi\u00f3n de mediadores de la inflamaci\u00f3n. Una regulaci\u00f3n inapropiada en la producci\u00f3n de estos mediadores puede dar lugar a inflamaci\u00f3n cr\u00f3nica y fibrosis. En este trabajo se ha estudiado c\u00f3mo se regula la expresi\u00f3n de rantes\/ccl5 en fibroblastos d\u00e9rmicos en cultivo estimulados con tnf-alfa y ifn-gamma como un modelo in vitro que mimetiza la funci\u00f3n de fibroblastos durante el proceso inflamatorio. As\u00ed mismo se estudi\u00f3 el efecto de factores pro- y anti-inflamatorios (il-17, il-4, il-10, il-13 y \u00e1cido retinoico) sobre la expresi\u00f3n de rantes\/ccl5 inducida por tnf-alfa e ifn-gamma.  los resultados muestran que tnf-alfa e ifn-gamma aumentan de forma sin\u00e9rgica la producci\u00f3n de la prote\u00edna y el mrna y rantes\/ccl5 en fibroblastos. Esta regulaci\u00f3n es ejercida a nivel transcripcional en el caso del tnf-alfa , y a  nivel post-transcripcional en el caso de ifn-gamma. Las regiones implicadas en la regulaci\u00f3n de la activaci\u00f3n del promotor de rantes\/ccl5 son las regiones r(ab), que une la prote\u00edan p65\/p65.  la estimulaci\u00f3n con tnf-alfa, la regi\u00f3n r(d), que une irf-2\/3 de manera constitutiva y la regi\u00f3n r(g) que une las prote\u00ednas c-jun, jun d y jun d\/crem-1.  la mutaci\u00f3n de cada un de estas regiones llevadas la p\u00e9rdida completa o parcial de la actividad del promotor en fibroblastos. La inducci\u00f3n de rantes\/ccl5 se inhibe principalmente por la il-17, que act\u00faa a nivel transcripcional a trav\u00e9s de la regi\u00f3n r(ab). Las il-4, il-10, il-13 y el \u00e1cido retinoico inhiben el aumento de la producci\u00f3n de la prote\u00edna en respuesta al tnf-alfa. la inhibici\u00f3n producida por el \u00e1cido retinoico se ejerce a nivel transcripcional, aunque ninguna de las regiones estudiadas en este trabajo est\u00e1 implicado<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Regulaci\u00f3n transcripcional del gen de rantes\/ccl5 en fibroblastos d\u00e9rmicos; modulaci\u00f3n a trav\u00e9s de factores pro- y anti-inflamatorios<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Regulaci\u00f3n transcripcional del gen de rantes\/ccl5 en fibroblastos d\u00e9rmicos; modulaci\u00f3n a trav\u00e9s de factores pro- y anti-inflamatorios <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Vicente Arroyo Ana Bel\u00e9n <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 05\/03\/2004<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>J. Nelson Peter<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal:  P\u00e9rez gomariz rosa Mar\u00eda <\/li>\n<li>elfride N\u00ed\u00b6ssner (vocal)<\/li>\n<li>Mar\u00eda laura Garc\u00eda bermejo (vocal)<\/li>\n<li>Francisco Javier Lucio caza\u00f1a (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Vicente Arroyo Ana Bel\u00e9n La quimioquina rantes\/ccl5 es un potente quimioatrayente para diversas poblaciones leucocitarias. Los fibroblastos [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[1],"tags":[82291,31866,82290,82292,61634,82289],"class_list":["post-29007","post","type-post","status-publish","format-standard","hentry","category-sin-categoria","tag-elfride-nissner","tag-francisco-javier-lucio-cazana","tag-j-nelson-peter","tag-maria-laura-garcia-bermejo","tag-perez-gomariz-rosa-maria","tag-vicente-arroyo-ana-belen"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/29007","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=29007"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/29007\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=29007"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=29007"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=29007"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}