{"id":2903,"date":"1994-01-01T00:00:00","date_gmt":"1994-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/1994\/01\/01\/factores-pronosticos-en-linfomas-de-grado-intermedio-y-alto-de-malignidad\/"},"modified":"1994-01-01T00:00:00","modified_gmt":"1994-01-01T00:00:00","slug":"factores-pronosticos-en-linfomas-de-grado-intermedio-y-alto-de-malignidad","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/factores-pronosticos-en-linfomas-de-grado-intermedio-y-alto-de-malignidad\/","title":{"rendered":"Factores pronosticos en linfomas de grado intermedio y alto de malignidad."},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Rodriguez Diaz Pavon Jose <\/strong><\/h2>\n<p>Los esquemas terapeuticos actuales para los linfomas del grupo intermedio y alto grado de malignidad de la working formulation consiguen curar a un 50% de los pacientes.  con el fin de mejorar estos resultados y probar de una forma idonea la hipotesis de goldie-coloman se dise\u00f1o un esquema terapeutico basado en tres regimenes alternantes en una secuencia de tres cursos. Este esquema consta de los siguientes regimenes: asap (adriamicina, solumedrol, ara-c, platino), m-bacos (meto trexate, bleomicina, adriamicina, ciclofosfamida, vincristina, solumedrol) y mine (mesna, ifosfamida, mitoxantrona y etoposido). En 83 pacientes sometidos a este esquema se consiguieron un 97% de respuestas, con un 75% de respuestas completas. La supervivencia a los tres a\u00f1os de seguimiento medio es de un 63%. En un analisis multivariable la b2 microglobulina, n de leucocitos pretratamiento y el indice de dna emergieron como variables independientes en relacion a la supervivencia y el tiempo de fallo al tratamiento (ttf). Ningun sistema de riesgo (tumor score, indice internacional) pudo dividir la poblacion en diferentes grupos de riesgo, sin embargo el tumor score pudo definir un grupo de pacientes con tan buen pronostico que es posible que con esquemas terpapeceuticos menos agresivos que el actual pudieran curarse; de forma analgoa con el indice internacional de riesgo se consigue definir un grupo de muy mal pronostixo donde otras estrategias experimentales deben ser probadas. Del estudio de las variables pronosticas en se dise\u00f1o un modelo pronostico en base a la b2 microglubina y el n. De leucocitos pretratamiento que dividen la poblaciones en grupo de riesgo diferenciado.  este modelo debera ser probado en una poblacion independiente para demostrar con seguridad su utilidad practica.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Factores pronosticos en linfomas de grado intermedio y alto de malignidad.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Factores pronosticos en linfomas de grado intermedio y alto de malignidad. <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Rodriguez Diaz Pavon Jose <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Universitat de val\u00e9ncia (estudi general)<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1994<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Garc\u00eda Conde Bru Javier<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jaime Merino Sanchez <\/li>\n<li> Lopez Lopez Juan  Jos\u00e9 (vocal)<\/li>\n<li>Eduardo Garcia Granero Ximenez (vocal)<\/li>\n<li>Antonio Pascual Lopez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Rodriguez Diaz Pavon Jose Los esquemas terapeuticos actuales para los linfomas del grupo intermedio y alto grado [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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