{"id":29059,"date":"2004-08-03T00:00:00","date_gmt":"2004-08-03T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-de-la-senalizacion-intracelular-de-los-receptores-5-ht2-evaluacion-diferencial-para-antipsicoticos\/"},"modified":"2004-08-03T00:00:00","modified_gmt":"2004-08-03T00:00:00","slug":"estudio-de-la-senalizacion-intracelular-de-los-receptores-5-ht2-evaluacion-diferencial-para-antipsicoticos","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/santiago-de-compostela\/estudio-de-la-senalizacion-intracelular-de-los-receptores-5-ht2-evaluacion-diferencial-para-antipsicoticos\/","title":{"rendered":"Estudio de la se\u00f1alizaci\u00f3n intracelular de los receptores 5-ht2. evaluaci\u00f3n diferencial para antipsic\u00f3ticos"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Jos\u00e9 Manuel Brea Floriani <\/strong><\/h2>\n<p>Los receptores 5-ht2a y 5-ht2c, sobre los que act\u00faan algunos f\u00e1rmacos antipsic\u00f3ticos, son gpcrs para los que se conocen distintas conformaciones activas. Sin embargo, parad\u00f3jicamente no existen evidencias experimentales de la relaci\u00f3n entre la afinidad conformacional de los f\u00e1rmacos antipsic\u00f3ticos y su repercusi\u00f3n funcional y\/o terap\u00e9utica.  en la presente tesis doctoral hemos descrito metodolog\u00edas a la caracterizaci\u00f3n conformacional de los receptores 5-ht2 centrales, caracterizado el perfil conformacional de los antipsic\u00f3ticos t\u00edpicos y at\u00edpicos y se han obtenido herramientas farmacol\u00f3gicas pertenecientes a una misma familia qu\u00edmica que permiten discriminar entre distintas conformaciones de los receptores 5-ht2 localizados en el snc. Estas herramientas permitir\u00e1n avanzar en el estudio de la implicaci\u00f3n de las distintas conformaciones de estos receptores en la terap\u00e9utica de la esquizofrenia mediante estudios \u00abin vivo\u00bb en animales de experimentaci\u00f3n.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio de la se\u00f1alizaci\u00f3n intracelular de los receptores 5-ht2. evaluaci\u00f3n diferencial para antipsic\u00f3ticos<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio de la se\u00f1alizaci\u00f3n intracelular de los receptores 5-ht2. evaluaci\u00f3n diferencial para antipsic\u00f3ticos <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Jos\u00e9 Manuel Brea Floriani <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Santiago de compostela<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 08\/03\/2004<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Mar\u00eda  Isabel Loza Garcia<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: ferran Sanz carreras <\/li>\n<li>p. Clarke william (vocal)<\/li>\n<li>enrique Ravi\u00f1a rubira (vocal)<\/li>\n<li>guadalupe Mengod los arcos (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Jos\u00e9 Manuel Brea Floriani Los receptores 5-ht2a y 5-ht2c, sobre los que act\u00faan algunos f\u00e1rmacos antipsic\u00f3ticos, son [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[977],"tags":[2578,2515,26390,82398,9145,82399],"class_list":["post-29059","post","type-post","status-publish","format-standard","hentry","category-santiago-de-compostela","tag-enrique-ravina-rubira","tag-ferran-sanz-carreras","tag-guadalupe-mengod-los-arcos","tag-jose-manuel-brea-floriani","tag-maria-isabel-loza-garcia","tag-p-clarke-william"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/29059","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=29059"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/29059\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=29059"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=29059"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=29059"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}