{"id":29111,"date":"2004-10-03T00:00:00","date_gmt":"2004-10-03T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/implicacion-de-vip-y-pacap-en-la-diferenciacion-neuroendocrina-y-la-apoptosis-en-el-cancer-de-prostata\/"},"modified":"2004-10-03T00:00:00","modified_gmt":"2004-10-03T00:00:00","slug":"implicacion-de-vip-y-pacap-en-la-diferenciacion-neuroendocrina-y-la-apoptosis-en-el-cancer-de-prostata","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/alcala\/implicacion-de-vip-y-pacap-en-la-diferenciacion-neuroendocrina-y-la-apoptosis-en-el-cancer-de-prostata\/","title":{"rendered":"Implicacion de vip y pacap en la diferenciacion neuroendocrina y la apoptosis en el cancer de prostata."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Irene Gutierrez Ca\u00f1as <\/strong><\/h2>\n<p>Los neurop\u00e9ptidos vip (p\u00e9ptido intestinal vasoactivo) y pacap (p\u00e9ptido activador de la adenilato ciclasa hipofisiaria) son producidos por las l\u00edneas celulares de c\u00e1ncer de pr\u00f3stata lncap y pc3 que representan los estad\u00edos del c\u00e1ncer de pr\u00f3stata dependiente e independiente de andr\u00f3genos, respectivamente.  de los tres subtipos de receptores que existen para estos neurop\u00e9ptidos, los receptores comunes vpac1 y vpac2 se expresan en ambas l\u00edneas celulares, siendo el receptor vpac1 el mayoritario y m\u00e1s funcional en las dos l\u00edneas estudiadas. El receptor espec\u00edfico para pacap, pac1, se encuentra presente en las c\u00e9lulas lncap, pero no en las pc3.  estos p\u00e9ptidos inducen diferenciaci\u00f3n neuroendocrina en la l\u00ednea celular lncap a trav\u00e9s del receptor vpac1, implicando a las v\u00edas de se\u00f1alizaci\u00f3n de la pka, pi3k, erk y posiblemente ras.  vip y pacap son capaces de proteger de la apoptosis inducida por la deprivaci\u00f3n de suero en la l\u00ednea celular independiente de andr\u00f3genos, pc3, a trav\u00e9s del receptor vpac1.  en resumen, vip y pacap pueden actuar en esta gl\u00e1ndula como p\u00e9ptidos autocrinos\/paracrinos, relacionados con la progresi\u00f3n del c\u00e1ncer de pr\u00f3stata, desde un estado dependiente de andr\u00f3genos a otro estado independiente de andr\u00f3genos, patr\u00f3n que es indicio del aumento de la agresividad del tumor.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Implicacion de vip y pacap en la diferenciacion neuroendocrina y la apoptosis en el cancer de prostata.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Implicacion de vip y pacap en la diferenciacion neuroendocrina y la apoptosis en el cancer de prostata. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Irene Gutierrez Ca\u00f1as <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Alcal\u00e1<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 10\/03\/2004<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>M\u00aa Jos\u00e9 Carmena Sierra<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Juan  Carlos Prieto villap\u00fan <\/li>\n<li>rosa Perez gomariz (vocal)<\/li>\n<li>Jos\u00e9 Luis Pablos alvarez (vocal)<\/li>\n<li>ricardo Paniagua g\u00f3mez-\u00e1lvarez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Irene Gutierrez Ca\u00f1as Los neurop\u00e9ptidos vip (p\u00e9ptido intestinal vasoactivo) y pacap (p\u00e9ptido activador de la adenilato ciclasa [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[17426],"tags":[82508,62668,17527,17563,14274,72071],"class_list":["post-29111","post","type-post","status-publish","format-standard","hentry","category-alcala","tag-irene-gutierrez-canas","tag-jose-luis-pablos-alvarez","tag-juan-carlos-prieto-villapun","tag-ma-jose-carmena-sierra","tag-ricardo-paniagua-gomez-alvarez","tag-rosa-perez-gomariz"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/29111","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=29111"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/29111\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=29111"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=29111"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=29111"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}