{"id":29113,"date":"2004-10-03T00:00:00","date_gmt":"2004-10-03T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/modulacion-y-estudios-estructura-funcion-en-un-integrador-molecular-de-esta%c2%admulos-nocivos-termicos-y-qua%c2%admicos-el-receptor-trpv1\/"},"modified":"2004-10-03T00:00:00","modified_gmt":"2004-10-03T00:00:00","slug":"modulacion-y-estudios-estructura-funcion-en-un-integrador-molecular-de-esta%c2%admulos-nocivos-termicos-y-qua%c2%admicos-el-receptor-trpv1","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/miguel-hernandez-de-elche\/modulacion-y-estudios-estructura-funcion-en-un-integrador-molecular-de-esta%c2%admulos-nocivos-termicos-y-qua%c2%admicos-el-receptor-trpv1\/","title":{"rendered":"Modulaci\u00f3n y estudios estructura-funci\u00f3n en un integrador molecular de est\u00edmulos nocivos t\u00e9rmicos y qu\u00edmicos: el receptor trpv1"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Carolina Garc\u00eda Mart\u00ednez <\/strong><\/h2>\n<p>El receptor de vanilloides 1 (trpv1) ejerce una funci\u00f3n fundamental en transducci\u00f3n de se\u00f1ales nociceptivas t\u00e9rmicas y qu\u00edmicas. Los antagonistas de trpv1 son compuestos muy \u00fatiles para desvelar la contribuci\u00f3n de este receptor en dolor y, por tanto, como posibles analg\u00e9sicos.  este trabajo aborda la estrategia combinatoria para identificar bloqueadores no pet\u00eddicos de este receptor. Se identificaron dos compuestos que resultaron bloqueadores selectivos con eficacia micromolar por un mecanismo no competitivo. la administraci\u00f3n de estos compuestos atenu\u00f3 la nocicepci\u00f3n t\u00e9rmica y redujo el dolor y la inflamaci\u00f3n neurog\u00e9nica provocadas por inyecci\u00f3n de capsaicina y por aceite de mostaza. Estos bloqueadores pueden ser considerados pues como cabezas de serie para su desarrollo como analg\u00e9sicos en dolor inflamatorio.  adicionalmente, y con el fin de acelerar el proceso de identificaci\u00f3n de los detalles moleculares de la uni\u00f3n al receptor y el futuro dise\u00f1o de racional de antagonistas, se realizan estudios de estructura-funci\u00f3n sobre trpv1. Los residuos ac\u00eddicos localizados en la regi\u00f3n del poro, o lazo p, son importantes para las propiedades de bloqueo y permeabilidad, concretamente los amino\u00e1cidos d646 y e636. Junco con resultados obtenidos de otras mutaciones en estar regi\u00f3n, y en base a la estructura cristalizada del canal de potasio kcsa, se genera un modelo estructural de la regi\u00f3n del poro de trpv1.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Modulaci\u00f3n y estudios estructura-funci\u00f3n en un integrador molecular de est\u00edmulos nocivos t\u00e9rmicos y qu\u00edmicos: el receptor trpv1<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Modulaci\u00f3n y estudios estructura-funci\u00f3n en un integrador molecular de est\u00edmulos nocivos t\u00e9rmicos y qu\u00edmicos: el receptor trpv1 <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Carolina Garc\u00eda Mart\u00ednez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Miguel hern\u00e1ndez de elche<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 10\/03\/2004<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Antonio  Vicente Ferrer Montiel<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Carlos Belmonte mart\u00ednez <\/li>\n<li>Juan Lerma (vocal)<\/li>\n<li>angel Messeguer peypoch (vocal)<\/li>\n<li>eduardo Mu\u00f1oz blanco (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Carolina Garc\u00eda Mart\u00ednez El receptor de vanilloides 1 (trpv1) ejerce una funci\u00f3n fundamental en transducci\u00f3n de se\u00f1ales [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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