{"id":29114,"date":"2004-11-03T00:00:00","date_gmt":"2004-11-03T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudi-mitjana%c2%a7ant-microsca%c2%b2pia-de-fora%c2%a7a-ata%c2%b2mica-de-la-meca-nica-de-ca%c2%a8l-lules-epitelials-alveolars-en-resposta-a-trombina\/"},"modified":"2004-11-03T00:00:00","modified_gmt":"2004-11-03T00:00:00","slug":"estudi-mitjana%c2%a7ant-microsca%c2%b2pia-de-fora%c2%a7a-ata%c2%b2mica-de-la-meca-nica-de-ca%c2%a8l-lules-epitelials-alveolars-en-resposta-a-trombina","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/barcelona\/estudi-mitjana%c2%a7ant-microsca%c2%b2pia-de-fora%c2%a7a-ata%c2%b2mica-de-la-meca-nica-de-ca%c2%a8l-lules-epitelials-alveolars-en-resposta-a-trombina\/","title":{"rendered":"Estudi mitjan\u00c1\u00a7ant microsc\u00f3pia de for\u00c1\u00a7a at\u00f3mica de la mec\u00c1\u00a0nica de c\u00e9l-lules epitelials alveolars en  resposta a trombina."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Lara Buscemi Estefanell <\/strong><\/h2>\n<p>La integridad de la barrera alviolo-capilar, formada por una monocapa de c\u00e9lulas del epitelio alveolar separadas de una monocapa de c\u00e9lulas del endotelio vascular por una fina l\u00e1mina de matriz extracelular, se ve gravemente comprometida en procesos inflamatorios.Uno de los mediadores inflamatorios mejor estudiados que afectan esta barrera es la trombina.  para comprender la importancia de las propiedades mec\u00e1nicas de las c\u00e9lulas del epitelio alveolar en condiciones de inflamaci\u00f3n, se ha abordado mediante microscop\u00eda de fuerza at\u00f3mica(afm)el estudio de la microreolog\u00eda del citoesqueleto de c\u00e9lulas epiteliales alveolares de la l\u00ednea a549  y sus cambios en respuesta a trombina, as\u00ed como los mecanismos moleculares subyacentes.Se ha estudiado el papel de la integridad del citoesqueleto en la respuesta mec\u00e1nica de las c\u00e9lulas dela l\u00ednea epitelial alveolar a549 a trav\u00e9s de la evoluci\u00f3n temporal de los cambios en las propiedades mec\u00e1nicas (rigidez y fuerza de indentaci\u00f3n)como consecuencia de la ruptura de los filamentos de activa y los microt\u00fabulos.Se ha analizado la implicaci\u00f3n de la activaci\u00f3n del motor de actina-miosina y el grado de participaci\u00f3n de la kinada de la cadena ligera de la miosina (mlck) y de rho kinasa (rock)en la respuesta mec\u00e1nica de las c\u00e9lulas a549 a trombina.  el conjunto de datos obtenidos de esta tesis sugiere que el mediador inflamatorio trombina provoca la activaci\u00f3n de la maquina contr\u00e1ctil de actina-miosina.Esta activaci\u00f3n, asociada a un incremento de rigidez desplazar\u00eda el equilibrio de fuerzas que mantiene la integridad de la barrera alveolo-capilar, contribuyendo a la formaci\u00f3n de brechas intercelulares, con la consiguiente formaci\u00f3n de edema y la infeltraci\u00f3n de c\u00e9lulas inflamatorias en el espacio alveolar.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudi mitjan\u00c1\u00a7ant microsc\u00f3pia de for\u00c1\u00a7a at\u00f3mica de la mec\u00c1\u00a0nica de c\u00e9l-lules epitelials alveolars en  resposta a trombina.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudi mitjan\u00c1\u00a7ant microsc\u00f3pia de for\u00c1\u00a7a at\u00f3mica de la mec\u00c1\u00a0nica de c\u00e9l-lules epitelials alveolars en  resposta a trombina. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Lara Buscemi Estefanell <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 11\/03\/2004<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Daniel Navajas Navarro<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: jordi Berm\u00fadez m\u00e1s <\/li>\n<li>teresa Roig rovira (vocal)<\/li>\n<li>daniel Closa autet (vocal)<\/li>\n<li>joaquin Sanchis aldas (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Lara Buscemi Estefanell La integridad de la barrera alviolo-capilar, formada por una monocapa de c\u00e9lulas del epitelio [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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