{"id":29118,"date":"2004-11-03T00:00:00","date_gmt":"2004-11-03T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/el-sistema-hla-en-el-asma-asociacion-del-genotipo-drb101-dqb10501-con-el-asma-alergico-a-artemisia-vulgaris\/"},"modified":"2004-11-03T00:00:00","modified_gmt":"2004-11-03T00:00:00","slug":"el-sistema-hla-en-el-asma-asociacion-del-genotipo-drb101-dqb10501-con-el-asma-alergico-a-artemisia-vulgaris","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/murcia\/el-sistema-hla-en-el-asma-asociacion-del-genotipo-drb101-dqb10501-con-el-asma-alergico-a-artemisia-vulgaris\/","title":{"rendered":"El sistema hla en el asma: asociaci\u00f3n del genotipo drb1*01-dqb1*0501 con el asma alergico a artemisia vulgaris"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Alberto Torio Ruiz <\/strong><\/h2>\n<p>Este trabajo profundiza en el conocimiento de los mecanismos inmunol\u00f3gicos en la naturaleza del asma.  en la primera parte de nuestro trabajo nos centramos en el an\u00e1lisis de los pacientes intr\u00ednsecos y su comparaci\u00f3n con los extr\u00ednsecos, estudiando la hip\u00f3tesis de que al ser las infecciones respiratorias, especialmente por el virus respiratorio sincitial y el parainfluenza, la causa m\u00e1s frecuente de exacerbaciones agudas en el asma intr\u00ednseco, estos agentes infecciosos tuvieran alguna relaci\u00f3n con las mol\u00e9culas de hla (presumiblemente de clase i), de una forma similar a la encontrada en otras enfermedades significativas (tor\u00edo y col., 2000).  el papel del hla ha resultado m\u00e1s evidente en el caso del asma al\u00e9rgico, ya que se ha conseguido describir una serie de asociaciones estad\u00edsticamente significativas con alelos de hla de clase ii al considerar la respuesta a diferentes alergenos. Estos resultados han sido especialmente relevantes en el caso de pacientes asma al\u00e9rgico a artemisia vulgaris, donde se ha encontrado una asociaci\u00f3n con los alelos hla-drb1*01-dqb1*0501 que hasta ahora no hab\u00eda sido descrita (tor\u00edo y col.,2003).  adem\u00e1s, en nuestro poblaci\u00f3n tambi\u00e9n observamos las asociaciones estad\u00edsticamente significativas como la asociaci\u00f3n entre la alergia a parietaria judaica con los alelos drb1*01-dqb1*0501, el crecimiento del alelo drb1*03 en pacientes con asma al\u00e9rgico a lolium perenne, y el efecto protector que puede ser asignado al alelo drb1*11 para proteger frente a la sensibilizaci\u00f3n a salsola kali y olea europea. Lo mismo que en la mayor\u00eda de estudios previos todas las asociaciones encontradas lo son con alelos de clase ii.  posteriormente nos centramos en el estudio de la asociaci\u00f3n encontrada con la respuesta al\u00e9rgica a artemisia vulgaris. Para ello se decidi\u00f3 purificar dos alergenos mayoritarios de su polen y realizar diversas determinaciones de inmunoglobulinas espec\u00edficas y estudios funciona<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>El sistema hla en el asma: asociaci\u00f3n del genotipo drb1*01-dqb1*0501 con el asma alergico a artemisia vulgaris<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 El sistema hla en el asma: asociaci\u00f3n del genotipo drb1*01-dqb1*0501 con el asma alergico a artemisia vulgaris <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Alberto Torio Ruiz <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Murcia<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 11\/03\/2004<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Alvarez Lopez M. Rocio<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal:  Lozano teruel Jos\u00e9 Antonio <\/li>\n<li>aurelio Luna maldonado (vocal)<\/li>\n<li>Antonio Alonso ortiz (vocal)<\/li>\n<li>Luisa Mar\u00eda Villar guimerans (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Alberto Torio Ruiz Este trabajo profundiza en el conocimiento de los mecanismos inmunol\u00f3gicos en la naturaleza del [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[8235],"tags":[82522,62377,2186,3274,8312,70141],"class_list":["post-29118","post","type-post","status-publish","format-standard","hentry","category-murcia","tag-alberto-torio-ruiz","tag-alvarez-lopez-m-rocio","tag-antonio-alonso-ortiz","tag-aurelio-luna-maldonado","tag-lozano-teruel-jose-antonio","tag-luisa-maria-villar-guimerans"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/29118","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=29118"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/29118\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=29118"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=29118"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=29118"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}