{"id":29145,"date":"2004-12-03T00:00:00","date_gmt":"2004-12-03T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/mecanismos-de-transduccion-de-senales-implicados-en-la-tolerancia-dependencia-de-morfina\/"},"modified":"2004-12-03T00:00:00","modified_gmt":"2004-12-03T00:00:00","slug":"mecanismos-de-transduccion-de-senales-implicados-en-la-tolerancia-dependencia-de-morfina","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/murcia\/mecanismos-de-transduccion-de-senales-implicados-en-la-tolerancia-dependencia-de-morfina\/","title":{"rendered":"Mecanismos de transducci\u00f3n de se\u00f1ales implicados en la tolerancia\/dependencia de morfina"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Manuela Cerezo Iniesta <\/strong><\/h2>\n<p>Actualmente existen numerosos estudios acerca de los mecanismos implicados en la tolerancia dependencia de opioides. Sin embargo, los mecanismos celulares y moleculares involucrados en estos fen\u00f3menos a nivel perif\u00e9rico y concretamente a nivel cardiaco son menos conocidos. Esto se debe a diferentes motivos, entre otros, la compleja regulaci\u00f3n nerviosa que recibe el coraz\u00f3n, la existencia de diferentes tipos de receptores opioides y ligandos end\u00f3genos, as\u00ed como a las distintas interacciones que se producen entre los opioides y otros neurotransmisores.  en cuanto a la inervaci\u00f3n cardiaca, la regulaci\u00f3n nerviosa extr\u00ednseca del coraz\u00f3n ha sido extensamente estudiada, conoci\u00e9ndose el importante control aut\u00f3nomo que recibe el coraz\u00f3n, a trav\u00e9s del sistema nervioso simp\u00e1tico (sns), sistema nervioso parasimp\u00e1tico(snps) y fibras no colin\u00e9rgicas no adren\u00e9rgicas(ncna).  junto a esta inervaci\u00f3n extr\u00ednseca, se ha descrito la existencia de un plexo cardiaco intr\u00ednseco.Este plexo,est\u00e1 constituido por neuronas cuyos somas est\u00e1n localizadas intracardiacamente.Estas neuronas pueden liberar distintos neurotransmisores tales como moradrenalina(na), acetilcolina y diferentes neurop\u00e9ptidos.Diversos estudios electrofisiol\u00f3gicos y bioqu\u00edmicos han demostrado que la activaci\u00f3n de diferentes neuronas que constituyen este plexo cardiaco intr\u00ednseco desencadenan efectos cardiacos tanto inhibitorios como excitatorios.Lo que demuestra que este plexo tiene capacidad integradora suficiente como par apoder funcionar con independencia del sistema nervioso central (snc).  este plexo tambi\u00e9n, recibe aferencias del sns, snps, as\u00ed como, de fibras ncna que regulan la respuesta de las neuronas intracardiacas a trav\u00e9s de mecanismos todav\u00eda no bien establecidos.  la administraci\u00f3n aguda de opioides produce una inhibici\u00f3n de la adenilato ciclasa y de la guanilato ciclasa provocando un descenso en los niveles de ampc y gmpc, que a su vez reducir<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Mecanismos de transducci\u00f3n de se\u00f1ales implicados en la tolerancia\/dependencia de morfina<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Mecanismos de transducci\u00f3n de se\u00f1ales implicados en la tolerancia\/dependencia de morfina <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Manuela Cerezo Iniesta <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Murcia<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 12\/03\/2004<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Mar\u00eda Luisa Laorden Carrasco<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Mar\u00eda Amor hurle <\/li>\n<li>Jes\u00fas Hern\u00e1ndez cascales (vocal)<\/li>\n<li> Vargas alvarez-castellanos Mar\u00eda  Luisa (vocal)<\/li>\n<li> Garc\u00eda barrado Mar\u00eda  Jos\u00e9 (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Manuela Cerezo Iniesta Actualmente existen numerosos estudios acerca de los mecanismos implicados en la tolerancia dependencia de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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