{"id":29147,"date":"2004-12-03T00:00:00","date_gmt":"2004-12-03T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/sa%c2%adndrome-lipodistrofico-asociado-a-la-terapia-antirretroviral-de-gran-actividad-alteraciones-morfologicas-y-metabolicas-y-su-valor-diagnostico-y-pronostico\/"},"modified":"2004-12-03T00:00:00","modified_gmt":"2004-12-03T00:00:00","slug":"sa%c2%adndrome-lipodistrofico-asociado-a-la-terapia-antirretroviral-de-gran-actividad-alteraciones-morfologicas-y-metabolicas-y-su-valor-diagnostico-y-pronostico","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/oviedo\/sa%c2%adndrome-lipodistrofico-asociado-a-la-terapia-antirretroviral-de-gran-actividad-alteraciones-morfologicas-y-metabolicas-y-su-valor-diagnostico-y-pronostico\/","title":{"rendered":"\u00abs\u00edndrome lipodistr\u00f3fico asociado a la terapia antirretroviral de gran actividad: alteraciones morfol\u00f3gicas y metab\u00f3licas y su valor diagn\u00f3stico y pron\u00f3stico\u00bb"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Mart\u00edn Roces Eustaquio Rufino <\/strong><\/h2>\n<p>Antecedentes: la lipodistrofia es un s\u00edndrome descrito en pacientes vih en tratamiento antirretroviral de gran actividad (targa) que se caracteriza por redistribuci\u00f3n de la grasa corporal, hiperlipemai y resistencia a la insulina. La ecograf\u00eda de la grasa subcut\u00e1nea, tomograf\u00eda, resonancia nuclear magn\u00e9tica y dexa se han utilizado para cuantificar los cambios corporales acaecidos en la lipodistrofia y valorar su evoluci\u00f3n temporal. M\u00e1s del 30% de los pacientes vih en targa desarrollan un s\u00edndrome lipodistr\u00f3fico aunque hasta ahora no se han descrito factores capaces de predecirlo.  material y m\u00e9todos: 74 pacientes con infecci\u00f3n por vih con targa, 22 de los cuales eran \u00abnave\u00bb para este tratamiento fueron revisados trimestralmente durante 27 meses. Se determinaron en los mismos los niveles s\u00e9ricos de colesterol, colesterol hdl y ldl, triglic\u00e9ridos y niveles de glucosa (ttog). en cada revisi\u00f3n se realiz\u00f3 una valoraci\u00f3n de la lipodistrofia por el m\u00e9dico y por el paciente y se tomaron medidas antropom\u00e9tricas. Adem\u00e1s cada 6 meses se realiz\u00f3 una ecograf\u00eda de la grasa subcut\u00e1nea a nivel facial, tricipital, abdominal y de muslo y adem\u00e1s se midi\u00f3 la grasa perirrenal como representaci\u00f3n de la grasa visceral.  resultados: hemos observado que el grosor de la grasa perirrenal se incrementa de forma progresiva, correlacion\u00e1ndose muy bien, mediante la prueba de correlaci\u00f3n de pearson, con niveles elevados en suero de colesterol, triglic\u00e9ridos y ldl colesterol en los 74 pacientes vih estudiados (p menor 0,007 para todas estas variables). Tambi\u00e9n hab\u00eda una buena correlaci\u00f3n entre este par\u00e1metro y niveles elevados, tanto basales como a las 2 horas del ttog, de glucosa, insulina y p\u00e9ptido c (p menor 0,005), y con otras medidas antropom\u00e9tricas medidas por lipocaliper en los pacientes tanto \u00abnaive\u00bb como pretratados con targa (p menor 0,04). El di\u00e1metro ecogr\u00e1fico de la grasa perirrenal difer\u00eda significativamente en los 74 p<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>\u00abs\u00edndrome lipodistr\u00f3fico asociado a la terapia antirretroviral de gran actividad: alteraciones morfol\u00f3gicas y metab\u00f3licas y su valor diagn\u00f3stico y pron\u00f3stico\u00bb<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 \u00abs\u00edndrome lipodistr\u00f3fico asociado a la terapia antirretroviral de gran actividad: alteraciones morfol\u00f3gicas y metab\u00f3licas y su valor diagn\u00f3stico y pron\u00f3stico\u00bb <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Mart\u00edn Roces Eustaquio Rufino <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Oviedo<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 12\/03\/2004<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Victor Asensi Alvarez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal:  Arribas castrillo Jos\u00e9 manuel <\/li>\n<li>julio Collazos gonz\u00e1lez (vocal)<\/li>\n<li>esteban Martinez chamorro (vocal)<\/li>\n<li>  (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Mart\u00edn Roces Eustaquio Rufino Antecedentes: la lipodistrofia es un s\u00edndrome descrito en pacientes vih en tratamiento antirretroviral [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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