{"id":29185,"date":"2018-03-09T09:22:12","date_gmt":"2018-03-09T09:22:12","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/diversidad-genetica-del-vih-estudio-en-una-cohorte-de-muestras-cubanas\/"},"modified":"2018-03-09T09:22:12","modified_gmt":"2018-03-09T09:22:12","slug":"diversidad-genetica-del-vih-estudio-en-una-cohorte-de-muestras-cubanas","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/diversidad-genetica-del-vih-estudio-en-una-cohorte-de-muestras-cubanas\/","title":{"rendered":"Diversidad gen\u00e9tica del vih. estudio en una cohorte de muestras cubanas"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Teresa Cuevas Gonz\u00e1lez-nicol\u00e1s <\/strong><\/h2>\n<p>La variabilidad gen\u00e9tica del vih ha permitido su clasificaci\u00f3n en tres grupos; m, o y n. Dentro del grupo m se han descrito diferentes subtipos (a, b, c, d, f, g, h, j, k), que por el fen\u00f3meno de recombinaci\u00f3n han dado lugar a las formas circulantes recombinantes (crf), de las que hasta hoy se han descrito 15. A excepci\u00f3n de \u00e1frica, donde se han encontrado todos los subtipos descritos, en el resto de pa\u00edses suele predominar un determinado subtipo viral, as\u00ed en am\u00e9rica y europa occidental el subtipo mayoritario es el b.  en cuba la preValencia de la infecci\u00f3n por vih es una de las m\u00e1s bajas a nivel mundial, inferior al 0,1%, lo que corresponde a unos 3.200 afectados. estudios previos hab\u00edan demostrado que la infecci\u00f3n se deb\u00eda a virus de subtipo b, pero las caracter\u00edsticas especiales de este pa\u00eds, tanto geogr\u00e1ficas como pol\u00edticas, que han permitido la movilidad de personal militar a pa\u00edses de \u00e1frica, hac\u00edan sospechar que este panorama hubiera cambiado.  en este trabajo se analizan un total de 105 muestras recogidas en el a\u00f1o 1999, cuando se hab\u00edan descrito 1950 casos de infecci\u00f3n por vih, por lo que el n\u00famero de muestras supon\u00edan aproximadamente un 5% del total de afectados. hay que destacar que el 93% de los contagios se produjo dentro del pa\u00eds.  el estudio filogen\u00e9tico de las cepas virales se realiz\u00f3 mediante la secuenciaci\u00f3n de dos segmentos del genoma viral, parcialmente pol (proteasa y parte de la transcriptasa inversa) y env (el segmento c2-v3-c3). Se realizaron los \u00e1rboles filogen\u00e9ticos y las cepas recombinantes se estudiaron por bootscanning, utilizando el programa simplot.  este an\u00e1lisis demostr\u00f3 la presencia de virus de subtipo b en 50 muestras, mientras que las 55 restantes presentaron virus de subtipo no b. Dentro de estos \u00faltimos, encontramos un 22% de virus no recombinantes (d, h, j, c, f1 y g) y un 78% de virus recombinantes, representados por 14 formas gen\u00e9ticas, en las que participan<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Diversidad gen\u00e9tica del vih. estudio en una cohorte de muestras cubanas<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Diversidad gen\u00e9tica del vih. estudio en una cohorte de muestras cubanas <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Teresa Cuevas Gonz\u00e1lez-nicol\u00e1s <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 15\/03\/2004<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Rafael Najera  Morrondo<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: jose Prieto prieto <\/li>\n<li>raul Ortiz de lejarazu leonardo (vocal)<\/li>\n<li>Carlos Jorge Domingo  fernandez (vocal)<\/li>\n<li>Juan  Jos\u00e9 Mart\u00ednez irujo (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Teresa Cuevas Gonz\u00e1lez-nicol\u00e1s La variabilidad gen\u00e9tica del vih ha permitido su clasificaci\u00f3n en tres grupos; m, o [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[1],"tags":[70771,3474,46875,6962,4947,82676],"class_list":["post-29185","post","type-post","status-publish","format-standard","hentry","category-sin-categoria","tag-carlos-jorge-domingo-fernandez","tag-jose-prieto-prieto","tag-juan-jose-Martinez-irujo","tag-rafael-najera-morrondo","tag-raul-ortiz-de-lejarazu-leonardo","tag-teresa-cuevas-gonzalez-nicolas"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/29185","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=29185"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/29185\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=29185"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=29185"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=29185"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}