{"id":29189,"date":"2018-03-09T09:22:13","date_gmt":"2018-03-09T09:22:13","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/eficacia-antiparkinsoniana-de-ligandos-cannabinoides-del-receptor-cb1-en-un-modelo-animal-de-la-enfermedad-de-parkinson\/"},"modified":"2018-03-09T09:22:13","modified_gmt":"2018-03-09T09:22:13","slug":"eficacia-antiparkinsoniana-de-ligandos-cannabinoides-del-receptor-cb1-en-un-modelo-animal-de-la-enfermedad-de-parkinson","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sevilla\/eficacia-antiparkinsoniana-de-ligandos-cannabinoides-del-receptor-cb1-en-un-modelo-animal-de-la-enfermedad-de-parkinson\/","title":{"rendered":"Eficacia antiparkinsoniana de ligandos cannabinoides del receptor cb1 en un modelo animal de la enfermedad de parkinson"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Isabel Caraballo Ramos <\/strong><\/h2>\n<p>Objetivos. La implicaci\u00f3n del sistema endocannabinoide en la enfermedad de parkinson se ha puesto en evidencia los \u00faltimos a\u00f1os. Se ha propuesto que ser\u00edan los antagonistas cannabinoides del receptor cb1 los f\u00e1rmacos \u00fatiles para el tratamiento del parkinson, ya que la inyecci\u00f3n intraestriatal de anandamida en ratas disminuye la s\u00edntesis de dopamina por las neuronas dopamin\u00e9rgicas nigroestriatales. Se ha comprobado la eficacia de antagonistas cannabinoides en el modelo animal de parkinson de la reserpina en ratas, con buenos resultados, no obteni\u00e9ndose los mismos resultados en el modelo de mptp en monos. Por otra parte, los agonistas cannabinoides del receptor cb1 tienen efecto sobre la actividad motora, desarrollando hiperactividad motora a dosis bajas e hipoactividad a dosis m\u00e1s altas.  los objetivos de la presente tesis doctoral han sido evaluar la eficacia antiparkinsoniana de 2 antagonistas cannabinoides del receptor cb1, sr141716a y am251, y su interacci\u00f3n con receptores dopamin\u00e9rgicos a nivel estriatal, y valorar la eficacia antiparkinsoniana de un agonista cannabinoide cb1, el am404, junto a su interacci\u00f3n con receptores dopamin\u00e9rgicos y serotonin\u00e9rgicos en el estriado. Para ello se ha utilizado el modelo de parkinson de la 6-ohda en ratas. Adem\u00e1s se han estudiado 2 variables en este modelo: la existencia de correlaci\u00f3n entre el grado de destrucci\u00f3n neuronal en la sustancia negra (medido mediante recuento neuronal tras inmunohistoqu\u00edmica para tirosina-hidroxilasa) y la asimetr\u00eda motora medida mediante el test de giro tras anfetamina (relaci\u00f3n no estudiada hasta el momento); y el tipo de hipersensibilidad dopamin\u00e9rgica que presentan las ratas hemiparkinsonianas (d1 \u00f3 d2).  resultados y conclusiones.  estudios sobre el modelo de lesi\u00f3n unilateral con 6-ohda en ratas. Los datos indican que existe una tendencia al aumento de la asimetr\u00eda motora medida mediante el giro tras anfetamina en paralelo a una mayo<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Eficacia antiparkinsoniana de ligandos cannabinoides del receptor cb1 en un modelo animal de la enfermedad de parkinson<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Eficacia antiparkinsoniana de ligandos cannabinoides del receptor cb1 en un modelo animal de la enfermedad de parkinson <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Isabel Caraballo Ramos <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Sevilla<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 15\/03\/2004<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Emilio Fernandez Espejo<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Juan Bellido gomez <\/li>\n<li>Javier Fernandez ruiz (vocal)<\/li>\n<li>isabel Serrano molina (vocal)<\/li>\n<li> Lopez de ceballos lafarga Mar\u00eda (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Isabel Caraballo Ramos Objetivos. La implicaci\u00f3n del sistema endocannabinoide en la enfermedad de parkinson se ha puesto [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[10715],"tags":[10089,82682,20578,23013,82683,55116],"class_list":["post-29189","post","type-post","status-publish","format-standard","hentry","category-sevilla","tag-emilio-fernandez-espejo","tag-isabel-caraballo-ramos","tag-isabel-serrano-molina","tag-javier-fernandez-ruiz","tag-juan-bellido-gomez","tag-lopez-de-ceballos-lafarga-maria"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/29189","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=29189"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/29189\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=29189"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=29189"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=29189"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}