{"id":29194,"date":"2018-03-09T09:22:13","date_gmt":"2018-03-09T09:22:13","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-de-los-mecanismos-de-accion-independientes-de-prostaglandinas-de-los-antiinflamatorios-no-esteroideos\/"},"modified":"2018-03-09T09:22:13","modified_gmt":"2018-03-09T09:22:13","slug":"estudio-de-los-mecanismos-de-accion-independientes-de-prostaglandinas-de-los-antiinflamatorios-no-esteroideos","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-de-los-mecanismos-de-accion-independientes-de-prostaglandinas-de-los-antiinflamatorios-no-esteroideos\/","title":{"rendered":"Estudio de los mecanismos de acci\u00f3n independientes de prostaglandinas de los antiinflamatorios no esteroideos"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Gomez Gaviro M. Victoria <\/strong><\/h2>\n<p>Nuestro grupo ha descrito que algunos antiinflamatorios no esteroideos (aines) pueden inducir el corte y liberaci\u00f3n de la selectina- l en pmn neutr\u00f3filos a trav\u00e9s de un mecanismo a\u00fan no completamente aclarado pero aparentemetne independiente de la activaci\u00f3n celular. En el presente estudio analizamos difrentes efectos biol\u00f3gicos de estos f\u00e1rmacos que pueden explicar su capacidad de liberar la selectina-l. Los aines producen una reducci\u00f3n variable en la concentraci\u00f3n de atp intracelular en los pmn neutr\u00f3filos que se correlaciona con su capacidad de liberar la selectina-l. Estos resultados sugieren que nos niveles de atp deben desepe\u00f1ar un papel relevante en la regulaci\u00f3n del nivel de expresi\u00f3n de la selectina-l, al menos en parte, debido a su capacidad para disminuir el estado energ\u00e9tico celular. Adem\u00e1s, hemos identificado a la difenilamina como la estructura qu\u00edmica com\u00fan en la que reside la capacidad de los aines de inducir el corte de la selectina -l a trav\u00e9s de un mecanismo independiente de prostaglandinas y probablemente asociado a la regulaci\u00f3n del atp intracelular. Los aines basados en la difenilamina no fueron capaces de inducir la p\u00e9rdida de la selectina-l en c\u00e9lulas drm-\/-, una l\u00ednea monoc\u00edtica de rat\u00f3n deficiente en el enzima conversora del tnf-alfa o tace, lo que indica que esta metaloproteasa participa en el corte de la selectina-l inducido por aines en pmn neutr\u00f3filos.  el conocimiento de estos nuevos mecanismos  de acci\u00f3n de los aines pueden ayudar al desarrollo de f\u00e1rmacos antiinflamatorios basados en su capacidad de bloquear la funci\u00f3n de la selectina-l y que carezcan de los efectos secundarios derivados de la inhibici\u00f3n sist\u00e9mica de la s\u00edntesis de prostaglandinas.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio de los mecanismos de acci\u00f3n independientes de prostaglandinas de los antiinflamatorios no esteroideos<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio de los mecanismos de acci\u00f3n independientes de prostaglandinas de los antiinflamatorios no esteroideos <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Gomez Gaviro M. Victoria <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 15\/03\/2004<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Federico D\u00edaz Gonz\u00e1lez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Francisco Sanchez Madrid <\/li>\n<li>tom\u00e1s Gonz\u00e1lez Garc\u00eda (vocal)<\/li>\n<li>faustino Mollinerdo (vocal)<\/li>\n<li>pedro Sabando su\u00e1rez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Gomez Gaviro M. Victoria Nuestro grupo ha descrito que algunos antiinflamatorios no esteroideos (aines) pueden inducir el [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[1],"tags":[82699,60867,14425,82698,14559,49410],"class_list":["post-29194","post","type-post","status-publish","format-standard","hentry","category-sin-categoria","tag-faustino-mollinerdo","tag-federico-diaz-gonzalez","tag-francisco-sanchez-madrid","tag-gomez-gaviro-m-victoria","tag-pedro-sabando-suarez","tag-tomas-gonzalez-garcia"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/29194","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=29194"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/29194\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=29194"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=29194"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=29194"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}