{"id":29253,"date":"2018-03-09T09:22:18","date_gmt":"2018-03-09T09:22:18","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/nuevos-peptidomimeticos-beta-lactamicos-diseno-sintesis-y-analisis-estructural\/"},"modified":"2018-03-09T09:22:18","modified_gmt":"2018-03-09T09:22:18","slug":"nuevos-peptidomimeticos-beta-lactamicos-diseno-sintesis-y-analisis-estructural","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/pais-vasco-euskal-herriko-unibertsitatea\/nuevos-peptidomimeticos-beta-lactamicos-diseno-sintesis-y-analisis-estructural\/","title":{"rendered":"Nuevos peptidomimeticos beta-lactamicos: dise\u00f1o, sintesis y analisis estructural"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Benito Collado Ana Belen <\/strong><\/h2>\n<p>El trabajo realizado en la presente tesis doctoral ha permitido por primera vez el acceso a cis-3-amino-3,4-dialquil(aril)-b-lact\u00e1mas enantiom\u00e9ricamente puras mediante alquilaci\u00f3n directa en posici\u00f3n a de la b-lactama.  as\u00ed mismo, se ha logrado la transformaci\u00f3n directa del grupo bis (trimetilsilil) metilo unido al nitr\u00f3geno b-lactamico en carboximetilo para obtener de forma m\u00e1s directa los intermedios b-lact\u00e1micos clave que se incorporen a cadenas pept\u00eddicas preparando as\u00ed los primeros an\u00e1logos pept\u00eddicos b-lact\u00e1micos. el estudi conformacional de los mismos confirm\u00f3 la hip\u00f3tesis de que las unidades de azetidin-2-onas provocan un giro b cuando son incorporadas a cadenas pept\u00eddicas.  por \u00faltimo, el ensayo bil\u00f3gico de un peptidomim\u00e9tico b-lactamico an\u00e1logo de la melatostatina, p\u00e9ptido end\u00f3geno cuya conformaci\u00f3n bioactiva es un giro b tipo ii, han demostrado la actividad de este an\u00e1logo para aumentar la afinidad de los receptores d2 por agonistas dopamin\u00e9rgicos<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Nuevos peptidomimeticos beta-lactamicos: dise\u00f1o, sintesis y analisis estructural<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Nuevos peptidomimeticos beta-lactamicos: dise\u00f1o, sintesis y analisis estructural <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Benito Collado Ana Belen <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Pa\u00eds vasco\/euskal herriko unibertsitatea<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 18\/03\/2004<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Claudio Palomo Nicolau<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: javier Mendoza de <\/li>\n<li>Mar\u00eda del rosario Gonz\u00e1lez mu\u00f1iz (vocal)<\/li>\n<li>Jes\u00fas Jim\u00e9nez-barbero (vocal)<\/li>\n<li>Jos\u00e9 Mar\u00eda Lassaletta simon (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Benito Collado Ana Belen El trabajo realizado en la presente tesis doctoral ha permitido por primera vez [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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