{"id":29324,"date":"2018-03-09T09:22:24","date_gmt":"2018-03-09T09:22:24","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/efectos-antiangiogenicos-del-5-fluorouracilo\/"},"modified":"2018-03-09T09:22:24","modified_gmt":"2018-03-09T09:22:24","slug":"efectos-antiangiogenicos-del-5-fluorouracilo","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/efectos-antiangiogenicos-del-5-fluorouracilo\/","title":{"rendered":"Efectos antiangiogenicos del 5-fluorouracilo"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Casado Echarren Victoria M. <\/strong><\/h2>\n<p>Las conclusiones de la tesis fueron las siguientes:  1,- las c\u00e9lulas endoteliales en subconfluencia muestran mayor expresi\u00f3n de enzima \u00f3xido n\u00edtrico sintasa endotelial que las c\u00e9lulas endoteliales confluentes concidiendo con el aumento observado de la producci\u00f3n de \u00f3xido n\u00edtrico.  2,- en presencia del agente antitumoral 5-fluorouracilo, en c\u00e9lulas endoteliales subconfluentes, la expresi\u00f3n de \u00f3xido n\u00edtrico sintasa endotelial disminuye significativamente.  3,- el 5-fluorouracilo no afecta a la expresi\u00f3n de dicha enzima en c\u00e9luloas endoteliales confluentes.  4,- el 5-fluorouracilo disminuy\u00f3 la producci\u00f3n de \u00f3xido n\u00edtrico en las c\u00e9lulas endoteliales subconfluentes.  5,- este f\u00e1rmaco antitumoral produjo vacuolizaci\u00f3n citoplasm\u00e1tica y disgregaci\u00f3n nucleolar en c\u00e9lulas endoteliales confluentes y subconfluentes.  6,- la expresi\u00f3n de receptores del vegf, flt-1 y flk-1, era similar en c\u00e9lulas endoteliales confluentes y subconfluentes.  7,- la presencia de 5-fluorouracilo disminuye de forma significativa la expresi\u00f3n de flk-1 en c\u00e9lulas subconfluentes y la expresi\u00f3n de flt-1 en c\u00e9lulas confluentes.  8,- estos procesos descritos podr\u00edan explicar a nivel molecular los efectos antiangiog\u00e9nicos del 5-fluorouracilo sobre las c\u00e9lulas endoteliales.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Efectos antiangiogenicos del 5-fluorouracilo<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Efectos antiangiogenicos del 5-fluorouracilo <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Casado Echarren Victoria M. <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 23\/03\/2004<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Antonio L\u00f3pez Farr\u00e9<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: manuel G\u00f3nzalez bar\u00f3n <\/li>\n<li> Perez casas Ana martin (vocal)<\/li>\n<li>ricardo Sainz de la cuesta abbad (vocal)<\/li>\n<li>  (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Casado Echarren Victoria M. Las conclusiones de la tesis fueron las siguientes: 1,- las c\u00e9lulas endoteliales en [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[1],"tags":[14976,82996,12100,82997,82998],"class_list":["post-29324","post","type-post","status-publish","format-standard","hentry","category-sin-categoria","tag-antonio-lopez-farre","tag-casado-echarren-victoria-m","tag-manuel-gonzalez-baron","tag-perez-casas-ana-martin","tag-ricardo-sainz-de-la-cuesta-abbad"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/29324","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=29324"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/29324\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=29324"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=29324"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=29324"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}