{"id":29327,"date":"2018-03-09T09:22:24","date_gmt":"2018-03-09T09:22:24","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/enfoque-multirresolucion-para-la-busqueda-y-extraccion-de-caractera%c2%adsticas-estructurales-en-macromoleculas\/"},"modified":"2018-03-09T09:22:24","modified_gmt":"2018-03-09T09:22:24","slug":"enfoque-multirresolucion-para-la-busqueda-y-extraccion-de-caractera%c2%adsticas-estructurales-en-macromoleculas","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/enfoque-multirresolucion-para-la-busqueda-y-extraccion-de-caractera%c2%adsticas-estructurales-en-macromoleculas\/","title":{"rendered":"Enfoque multirresoluci\u00f3n para la b\u00fasqueda y extracci\u00f3n de caracter\u00edsticas estructurales en macromol\u00e9culas"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Natalia Jim\u00e9nez Lozano <\/strong><\/h2>\n<p>La microscop\u00eda electr\u00f3nica junto con las t\u00e9cnicas de reconstrucci\u00f3n ha emergido en los \u00faltimos a\u00f1os como una poderosa metodolog\u00eda dentro del campo de la determinaci\u00f3n de estructuras macromol\u00e9culas biol\u00f3gicas. Los microscopistas son conscientes de los potenciales de esta t\u00e9cnica que no s\u00f3lo permite la elucidaci\u00f3n de grandes complejos macromoleculares que son dif\u00edciles de estudiar mediante las t\u00e9cnicas de alta resoluci\u00f3n, sino tambi\u00e9n la observaci\u00f3n de cambios conformacionales sutiles que se dan frecuentemente en las macromol\u00e9culas cuando llevan a cabo sus funciones biol\u00f3gicas y cuando se unen a diferentes sustratos. La ausencia de conclusiones estructurales obtenidas mediante la comparaci\u00f3n de conjuntos de datos numerosos y diversos resueltos mediante 3d-em, nos anim\u00f3 a desarrollar y aplicar algunas herramientas. Como consecuencia se cre\u00f3 la base de datos femme para sentar las bases metodol\u00f3gicas e infraestructurales que permitieran un an\u00e1lisis exhaustivo de los vol\u00famenes de 3d-em indpendientemente de la resoluci\u00f3n alcanzada en cada estudio.  la base de datos femme almacena informaci\u00f3n geom\u00e9trica y topol\u00f3gica extra\u00edda a partir de los vol\u00famenes 3d-em mediante una serie de herramientas basadas en aplicaciones previas de la teor\u00eda de alfa-formas al an\u00e1lisis de las coordenadas at\u00f3micas. Los datos procesados siguiendo esta metodolog\u00eda se han almacenado en la base de datos femme.  el tipo de informaci\u00f3n estructural almacenada para cada entrada de femme est\u00e1 referida a canales, cavidades (cavidades internas -huevos- o cavidades externas -o bolsillos-), superfice y topolog\u00eda de las macromol\u00e9culas. Estas propiedades estructurales pueden ser extra\u00eddas f\u00e1cilmente a partir de la representaci\u00f3n en alfa-formas de la macromol\u00e9culas. La superficie y la topolog\u00eda son inherentes a la representaci\u00f3n en alfa-formas. Para la detecci\u00f3n y extracci\u00f3n de cavidades externas y canales, se aplicaron m\u00e9todos basados en<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Enfoque multirresoluci\u00f3n para la b\u00fasqueda y extracci\u00f3n de caracter\u00edsticas estructurales en macromol\u00e9culas<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Enfoque multirresoluci\u00f3n para la b\u00fasqueda y extracci\u00f3n de caracter\u00edsticas estructurales en macromol\u00e9culas <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Natalia Jim\u00e9nez Lozano <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 23\/03\/2004<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jos\u00e9 Mar\u00eda Carazo Garcia<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jos\u00e9 Mar\u00eda Valpuesta moralejo <\/li>\n<li> G\u00e1lvez ru\u00edz m. Jos\u00e9 (vocal)<\/li>\n<li> Oliver jim\u00e9nez  Jos\u00e9 l. (vocal)<\/li>\n<li>Luis Menendez arias (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Natalia Jim\u00e9nez Lozano La microscop\u00eda electr\u00f3nica junto con las t\u00e9cnicas de reconstrucci\u00f3n ha emergido en los \u00faltimos [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[1],"tags":[66272,14351,49522,40101,83002,21969],"class_list":["post-29327","post","type-post","status-publish","format-standard","hentry","category-sin-categoria","tag-galvez-ruiz-m-jose","tag-jose-maria-carazo-garcia","tag-jose-maria-valpuesta-moralejo","tag-luis-menendez-arias","tag-natalia-jimenez-lozano","tag-oliver-jimenez-jose-l"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/29327","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=29327"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/29327\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=29327"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=29327"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=29327"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}