{"id":29379,"date":"2018-03-09T09:22:29","date_gmt":"2018-03-09T09:22:29","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/papel-de-la-disfuncion-telomerica-en-el-envejecimiento-de-mama%c2%adferos-modelos-de-raton\/"},"modified":"2018-03-09T09:22:29","modified_gmt":"2018-03-09T09:22:29","slug":"papel-de-la-disfuncion-telomerica-en-el-envejecimiento-de-mama%c2%adferos-modelos-de-raton","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/papel-de-la-disfuncion-telomerica-en-el-envejecimiento-de-mama%c2%adferos-modelos-de-raton\/","title":{"rendered":"Papel de la disfunci\u00f3n telom\u00e9rica en el envejecimiento de mam\u00edferos: modelos de rat\u00f3n"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Sonia Franco N\u00fa\u00f1ez <\/strong><\/h2>\n<p>En las c\u00e9lulas de mam\u00edfero, el tel\u00f3mero protege los extremos de los cromosomas y permite la replicaci\u00f3n del dna sin p\u00e9rdida de secuencias codificantes. la disfunci\u00f3n telom\u00e9rica se asocia a inestabilidad gen\u00e9tica, envejecimiento prematuro y, en determinados contextos, c\u00e1ncer.  en ausencia de telomerasa, la transcriptasa reversa que elonga el tel\u00f3mero, \u00e9ste se acorta con cada divisi\u00f3n celular. Los ratones deficientes en telomerasas (terc-\/-) con tel\u00f3meros cr\u00edticamente cortos muestran los siguientes fenot\u00edpos en el sistema cardiovascular:  a,- d\u00e9ficit angiog\u00e9nico severo in vivo (en respuesta a implantes de matrigel o a implantes tumorales).  b,- enlentecimiento del desarrollo tumoral como consecuencia de este d\u00e9ficit vascular.  c,- protecci\u00f3n frente a la arteriosclerosis, debido al d\u00e9ficit proliferativo en las c\u00e9lulas vasculares e immunes.  d,- disminuci\u00f3n de la capacidad regenerativa del coraz\u00f3n adulto.  las prote\u00ednas ku86 y dna-pkcs, dos componentes de la v\u00eda de reparaci\u00f3n del adn por uni\u00f3n terminal no hom\u00f3loga (nhej), forman parte de la cromatina telom\u00e9rica. El estudio comparativo de las colonias de rat\u00f3n terc-\/-\/ku-\/- y terc-\/-\/dna-pkcs-\/- ha demostrado que:  a,- ku86 es un regulador negativo de la longuitud telom\u00e9rica.  b,- dna-pkcs interacciona funcionalmente con la telomerasa, ya que, en ausencia de \u00e9sta, el d\u00e9ficit de dna-pkcs acelera el acortamiento telom\u00e9rico.  c,- las fusiones entre extremos cromos\u00f3micos que han perdido las repeticiones telom\u00e9ricas est\u00e1n mediadas por la v\u00eda de uni\u00f3n terminal no hom\u00f3loga (nhej), ya que se rescatan en ausencia de ku86 \u00f3 dna-pkcs.  d,- ku86 y dna-pkcs se encuentran upstream de p53 en la se\u00f1alizaci\u00f3n de la disfunci\u00f3n telom\u00e9rica, ya que la apoptosis inducida por tel\u00f3meros cortos se rescata en ausencia de ku86 \u00f3 dna-pkcs.  el perfil transcripcional (arrays de oligonucle\u00f3tidos) de las c\u00e9lulas terc-\/-, ku86-\/- y terc-\/-\/ku86-\/- no difiere signif<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Papel de la disfunci\u00f3n telom\u00e9rica en el envejecimiento de mam\u00edferos: modelos de rat\u00f3n<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Papel de la disfunci\u00f3n telom\u00e9rica en el envejecimiento de mam\u00edferos: modelos de rat\u00f3n <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Sonia Franco N\u00fa\u00f1ez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 25\/03\/2004<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Mar\u00eda Antonia Blasco Marhuenda<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: federico Mayor menendez <\/li>\n<li>Juan  Miguel Redondo moya (vocal)<\/li>\n<li>Mar\u00eda no Barbacid montalb\u00e1n (vocal)<\/li>\n<li>Juan  Carlos Alonso navarro (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Sonia Franco N\u00fa\u00f1ez En las c\u00e9lulas de mam\u00edfero, el tel\u00f3mero protege los extremos de los cromosomas y [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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