{"id":29508,"date":"2018-03-09T09:22:40","date_gmt":"2018-03-09T09:22:40","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/efectos-del-trasplante-de-gla%c2%ada-envolvente-del-bulbo-olfatorio-en-un-modelo-de-lesion-fotoqua%c2%admica-de-la-medula-espinal-de-la-rata\/"},"modified":"2018-03-09T09:22:40","modified_gmt":"2018-03-09T09:22:40","slug":"efectos-del-trasplante-de-gla%c2%ada-envolvente-del-bulbo-olfatorio-en-un-modelo-de-lesion-fotoqua%c2%admica-de-la-medula-espinal-de-la-rata","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/efectos-del-trasplante-de-gla%c2%ada-envolvente-del-bulbo-olfatorio-en-un-modelo-de-lesion-fotoqua%c2%admica-de-la-medula-espinal-de-la-rata\/","title":{"rendered":"Efectos del trasplante de gl\u00edaenvolvente del bulbo olfatorio en un modelo de lesi\u00f3n fotoqu\u00edmica de la m\u00e9dula espinal de la rata"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Guillermo Garc\u00eda Al\u00edas <\/strong><\/h2>\n<p>En la presente tesis doctoral se ha caracterizado un modelo de lesi\u00f3n fotoqu\u00edmica de la m\u00e9dula espinal de la rata, basado en la aplicaci\u00f3n t\u00f3pica del agente fotoactivo rosa de bengala. En los diferentes grupos experimentales estudiados, se ha constatado que a mayor tiempo de fotoactivaci\u00f3n del colorante, mayor es la lesi\u00f3n producida en los animales, que desemboca en una p\u00e9rdida progresiva de las capacidades neurol\u00f3gicas y funcionales de \u00e9stos. Asimismo, las lesiones fotoqu\u00edmicas realizadas producen cambios en la reactividad glial y neuronal similares a los productos tras una lesi\u00f3n traum\u00e1tica de la m\u00e9dula espinal. adem\u00e1s, se ha constatado que lesiones realizadas en los segmentos lumbares producen d\u00e9ficits motores m\u00e1s severos que las producidas en los segmentos tor\u00e1cicos de la m\u00e9dula espinal, indicando la importancia de la ubicaci\u00f3n anat\u00f3mica de la lesi\u00f3n como causa de los d\u00e9ficits producida por \u00e9sta.  con el objetivo de avanzar en la b\u00fasqueda y mejora de una terapia promotora de la recuperaci\u00f3n funcional de la m\u00e9dula espinal da\u00f1ada, se han evaluado los efectos del transplante de gl\u00eda envolvente del bulbo olfatorio en animales con una lesi\u00f3n fotoqu\u00edmica. En los estudios a corto plazo, se ha evidenciado el papel neuroprotector ejercido por el transplante glial, ya que los animales con transplante presntaron una menor cavidad necr\u00f3tica, atribuible a una menor reactividad astrocitaria, que los animales del grupo control. Los estudios realizados a lo largo plazo muestran que los animales con el transplante celular presentaron mayor preservaci\u00f3n de par\u00e9quima medular, as\u00ed como una mejor respueta neurol\u00f3gica y funcional que los animales sin transplante. adem\u00e1s, en comparaci\u00f3n con el transplante de c\u00e9lulas de schwann, el trasnplante de gl\u00eda envolvente redujo la reactividad glial y promovi\u00f3 una mejor respuesta electrofisiol\u00f3gica. Por \u00faltimo, dada la gran variedad de procedimientos experimentales utilizados p<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Efectos del trasplante de gl\u00edaenvolvente del bulbo olfatorio en un modelo de lesi\u00f3n fotoqu\u00edmica de la m\u00e9dula espinal de la rata<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Efectos del trasplante de gl\u00edaenvolvente del bulbo olfatorio en un modelo de lesi\u00f3n fotoqu\u00edmica de la m\u00e9dula espinal de la rata <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Guillermo Garc\u00eda Al\u00edas <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 31\/03\/2004<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Enrique Verdu Navarro<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jos\u00e9 enrique Esquerda colell <\/li>\n<li> R\u00edo fern\u00e1ndez Jos\u00e9 Antonio  de (vocal)<\/li>\n<li>Juli\u00e1n Scott taylor (vocal)<\/li>\n<li>  (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Guillermo Garc\u00eda Al\u00edas En la presente tesis doctoral se ha caracterizado un modelo de lesi\u00f3n fotoqu\u00edmica de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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