{"id":29510,"date":"2018-03-09T09:22:40","date_gmt":"2018-03-09T09:22:40","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/utilidad-del-modelo-animal-de-endocarditis-para-la-evaluacion-de-nuevas-pautas-terapeuticas\/"},"modified":"2018-03-09T09:22:40","modified_gmt":"2018-03-09T09:22:40","slug":"utilidad-del-modelo-animal-de-endocarditis-para-la-evaluacion-de-nuevas-pautas-terapeuticas","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/utilidad-del-modelo-animal-de-endocarditis-para-la-evaluacion-de-nuevas-pautas-terapeuticas\/","title":{"rendered":"Utilidad del modelo animal de endocarditis para la evaluaci\u00f3n de nuevas pautas terap\u00e9uticas"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  L\u00f3pez Onrubia Pedro Manuel <\/strong><\/h2>\n<p>El modelo experimental de endocarditis en conejos reproduce de manera muy aproximada la fisiopatolog\u00eda de la enfermedad en los humanos. Los estudios de eficacia terap\u00e9utica que utilizan este modelo plantean el problema de las diferencias de los perfiles farmacocin\u00e9ticos en el suero de los humanos y de los conejos de los antibi\u00f3ticos que se estudian. Para soslayar este problema en el presente trabajo se recopilan los resultados de estudios de eficacia terap\u00e9utica en los que se ha empleado un modelo matem\u00e1tico que permite compensar la mayor velocidad de aliminaci\u00f3n de f\u00e1rmacos en los animales y simular los perfiles farmacocin\u00e9ticos de los antibi\u00f3ticos que se obtienen en el suero de los humanos y reproducirlos en conejos con endocarditis, mediante la perfusi\u00f3n con bombas de infusion controladas por ordenador. Se ha utilizado el modelo de endocarditis en conejos y la administraci\u00f3n de antibi\u00f3ticos simulando los perfiles farmacocin\u00e9ticos en humanos para evaluar tratamientos alternativos o diferentes pautas de administraci\u00f3n en la endocarditis experimental causada por cocos grampositivos y se presentan cuatro estudios.-  en el primero, la evaluaci\u00f3n de la eficacia de la combinaci\u00f3n de ampicilina con ceftriaxona, administradas simulando la farmacocin\u00e9tica de ambos antibi\u00f3ticos en los humanos, en la endocarditis experimental por enterococcus faecalis con resistencia de alto nivel a los aminogluc\u00f3sidos mostr\u00f3 que dicha combinaci\u00f3n es efectiva y reduce significativamente la carga bacteriana presente en las vegetaciones en comparaci\u00f3n con los animales que recibieron ampicilina sola.  el segundo estudio mostr\u00f3 que la combinaci\u00f3n de teicoplanina y gentamicina administradas en una sola dosis diaria y con perfiles farmacocin\u00e9ticos humanos ten\u00eda una eficacia similar al tratamiento convencional, ampicilina m\u00e1s gentamicina, en la endocarditis experimental por e.Faecalis.  en el tercer estudio se demostr\u00f3 que para el tratamien<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Utilidad del modelo animal de endocarditis para la evaluaci\u00f3n de nuevas pautas terap\u00e9uticas<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Utilidad del modelo animal de endocarditis para la evaluaci\u00f3n de nuevas pautas terap\u00e9uticas <\/li>\n<li><strong>Autor:<\/strong>\u00a0  L\u00f3pez Onrubia Pedro Manuel <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 31\/03\/2004<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Alberto Pahissa Berga<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: francesc Gudiol munt\u00e9 <\/li>\n<li>merc\u00e9 Gurgui ferrer (vocal)<\/li>\n<li>isabel Ruiz camps (vocal)<\/li>\n<li>josep Mar\u00eda Arnau de bol\u00f3s (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de L\u00f3pez Onrubia Pedro Manuel El modelo experimental de endocarditis en conejos reproduce de manera muy aproximada la [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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