{"id":29530,"date":"2004-01-04T00:00:00","date_gmt":"2004-01-04T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/nuevos-derivados-de-timina-y-6-aminouracilo-sa%c2%adntesis-y-evaluacion-frente-a-distintas-dianas-terapeuticas\/"},"modified":"2004-01-04T00:00:00","modified_gmt":"2004-01-04T00:00:00","slug":"nuevos-derivados-de-timina-y-6-aminouracilo-sa%c2%adntesis-y-evaluacion-frente-a-distintas-dianas-terapeuticas","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/nuevos-derivados-de-timina-y-6-aminouracilo-sa%c2%adntesis-y-evaluacion-frente-a-distintas-dianas-terapeuticas\/","title":{"rendered":"Nuevos derivados de timina y 6-aminouracilo: s\u00edntesis y evaluaci\u00f3n frente a distintas dianas terap\u00e9uticas"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Priego Crespo Eva M. <\/strong><\/h2>\n<p>Esta memoria se ha estructurado en 3 cap\u00edtulos independientes.  en el cap\u00edtulo 1, se recoge el dise\u00f1o y s\u00edntesis de una peque\u00f1a quimioteca de derivados de timina dirigida frente a las enzimas timidina fosforilasa y timidina quinasa 2. Bas\u00e1ndonos en inhbidiores de ambas enzimas previamente sintetizados en nuestro laboratorio, los compuestos contienen en su estructura un anillo de timina para su interacci\u00f3n con el sitio de uni\u00f3n del nucle\u00f3sido en ambas enzimas, y grupos de distinta naturaleza seg\u00fan se pretenda la interacci\u00f3n con una u otra enzima. En concreto, para la interacci\u00f3n con la enzima timidina fosforilasa se eligieron grupos fosfonatos e hidroxamatos, y para la interacci\u00f3n con la enzima timidina quinasa 2 grupos ciano y\/o arom\u00e1ticos. El procedimiento de s\u00edntesis elegido ha sido el acoplamiento entre derivados de timina con un grupo \u00e1cido terminal y aminas primarias convenientemente funcionalizadas.  en el cap\u00edtulo 2, se refleja la optimizaci\u00f3n de un nuevo y alternativo procedimiento para la funcionalizaci\u00f3n de la posici\u00f3n 3 de derivados de 6-aminouracilo. Dicho procedimiento consiste en la transformaci\u00f3n de los derivados de 6-aminouracilo en sus correspondientes n6 -(dimetilamino)metilen derivados por tratamiento con dmf-dma, seguido de la funcionalizaci\u00f3n en posici\u00f3n n-3 con distintos haluros de alquilo, alquinilo o bencilo en presencia de k2co3 o dbu. El procedimiento se completa con la eliminaci\u00f3n del grupo (demitilamino)metileno, ya sea pro tratamiento con nh3 acuoso o zncl2 en metanol dependiendo de la funcionalizaci\u00f3n introducida sobre la posici\u00f3n n-3.  en el cap\u00edtulo 3 se expone la s\u00edntesis de derivados de 1h,3h-pirido[2, 1-f]purina-2,4-dionas mediante un novedoso procedimiento sint\u00e9tico en dos pasos realizado \u00abone-pot\u00bb a partir de derivados de 6-amonouracilo, y del cual se ha propuesto adem\u00e1s un posible mecanismo. Este procedimiento implica la reacci\u00f3n de derivados de 6-aminouracilo con nbs<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Nuevos derivados de timina y 6-aminouracilo: s\u00edntesis y evaluaci\u00f3n frente a distintas dianas terap\u00e9uticas<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Nuevos derivados de timina y 6-aminouracilo: s\u00edntesis y evaluaci\u00f3n frente a distintas dianas terap\u00e9uticas <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Priego Crespo Eva M. <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/04\/2004<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> P\u00e9rez P\u00e9rez M. Jes\u00fas<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: nazario Martin leon <\/li>\n<li>eugenio Uriarte villares (vocal)<\/li>\n<li> Aran redo vicente j. (vocal)<\/li>\n<li>m teresa Ramos  garcia (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Priego Crespo Eva M. Esta memoria se ha estructurado en 3 cap\u00edtulos independientes. en el cap\u00edtulo 1, [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[1],"tags":[83455,3182,83456,37204,83454,83453],"class_list":["post-29530","post","type-post","status-publish","format-standard","hentry","category-sin-categoria","tag-aran-redo-vicente-j","tag-eugenio-uriarte-villares","tag-m-teresa-ramos-garcia","tag-nazario-martin-leon","tag-perez-perez-m-jesus","tag-priego-crespo-eva-m"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/29530","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=29530"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/29530\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=29530"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=29530"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=29530"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}