{"id":29570,"date":"2004-02-04T00:00:00","date_gmt":"2004-02-04T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-de-la-expresion-del-sistema-fibrinola%c2%adtico-y-del-sistema-de-las-metaloproteasas-en-el-cancer-de-mama\/"},"modified":"2004-02-04T00:00:00","modified_gmt":"2004-02-04T00:00:00","slug":"estudio-de-la-expresion-del-sistema-fibrinola%c2%adtico-y-del-sistema-de-las-metaloproteasas-en-el-cancer-de-mama","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-de-la-expresion-del-sistema-fibrinola%c2%adtico-y-del-sistema-de-las-metaloproteasas-en-el-cancer-de-mama\/","title":{"rendered":"Estudio de la expresi\u00f3n del sistema fibrinol\u00edtico y del sistema de las metaloproteasas en el c\u00e1ncer de mama"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Remedios Castell\u00f3 Cros <\/strong><\/h2>\n<p>La invasi\u00f3n tumoral y la metastasis requieren la regulaci\u00f3n coordinada de una serie de procesos adhesivos, proteol\u00edticos y migratorios. El sistema fibrinol\u00edtico y el sistema de las metaloproteasas juegan un papel clave en la degradaci\u00f3n de la matriz extracelular.  los estudios previos se han centrado en estudiar los niveles antig\u00e9nicos de componentes de ambos sistemas. En el presente trabajo se ha puesto a punto, por primera vez, la t\u00e9cnica de la rt-pcr cuantitativa en tiempo real para cuantificar los niveles de mrna de componentes del sistema fibrinol\u00edtico: upa, pai-1 y pai-3 y del sistema de las metaloproteasas mmp-3 y timp-1 en 76 tejidos de c\u00e1ncer de mama. Adem\u00e1s, se han cuantificado sus niveles antig\u00e9nicos y funcionales y se ha detectado la localizaci\u00f3n antig\u00e9nica de upa, pai-1 y pai-3- (inmunohistoqu\u00edmica) y la localizaci\u00f3n de mrna de upa y pai-1 (hibridaci\u00f3n in situ).  los resultados indican que la t\u00e9cnica rt-pcr cuantitativas en tiempo real permite una r\u00e1pida, reproducible, sensible y espec\u00edfica cuantificaci\u00f3n del mrna de upa, pai-1 pai-3, mmp-3 y timp-1 en c\u00e1ncer de mama. Adem\u00e1s se ha puesto de manifiesto que el pai-3 es expresado en c\u00e1ncer de mama.  los niveles antig\u00e9nicos y de mrna de upa, pai-1, pai-3 y timp-1 aumentaron significativamente con la gravedad del tumor y con la afectaci\u00f3n ganglionar.  los niveles antig\u00e9nicos de mmp-3 y pai-1 fueron significativamente mayores en pacientes con recaida que en pacientes sin afectaci\u00f3n ganglionar. Sin embargo, los niveles antig\u00e9nicos de pai-3 fueron significativamente mayores en pacientes sin reca\u00edda.  el pai-3 antig\u00e9nico fue localizado en las c\u00e9lulas del estoma que rodean a los tumorales. Por otro lado, el upa y pai-1 antig\u00e9ninco fueron localizados en las c\u00e9lulas del etoma y en los tumorales; sin embargo sus mrnas fueron localizados en el estoma. Indicando de upa y pai-1 son sintetizados en el estoma y posteriormente captados por las c\u00e9lulas tumor<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio de la expresi\u00f3n del sistema fibrinol\u00edtico y del sistema de las metaloproteasas en el c\u00e1ncer de mama<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio de la expresi\u00f3n del sistema fibrinol\u00edtico y del sistema de las metaloproteasas en el c\u00e1ncer de mama <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Remedios Castell\u00f3 Cros <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Universitat de val\u00e9ncia (estudi general)<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 02\/04\/2004<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Amparo Estell\u00e9s Cort\u00e9s<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: jos\u00e9 Cabo soler <\/li>\n<li>Jos\u00e9 Antonio Paramo fernandez (vocal)<\/li>\n<li> Fuster diana Carlos Alberto (vocal)<\/li>\n<li>edelmiro Ragan\u00f3n salvador (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Remedios Castell\u00f3 Cros La invasi\u00f3n tumoral y la metastasis requieren la regulaci\u00f3n coordinada de una serie de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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