{"id":29574,"date":"2004-02-04T00:00:00","date_gmt":"2004-02-04T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-de-la-interleucina-10-y-de-la-molecula-de-adhesion-intercelular-1-en-la-pregresion-maligna-del-melanoma-humano\/"},"modified":"2004-02-04T00:00:00","modified_gmt":"2004-02-04T00:00:00","slug":"estudio-de-la-interleucina-10-y-de-la-molecula-de-adhesion-intercelular-1-en-la-pregresion-maligna-del-melanoma-humano","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/pais-vasco-euskal-herriko-unibertsitatea\/estudio-de-la-interleucina-10-y-de-la-molecula-de-adhesion-intercelular-1-en-la-pregresion-maligna-del-melanoma-humano\/","title":{"rendered":"Estudio de la interleucina-10 y de la mol\u00e9cula de adhesi\u00f3n intercelular-1 en la pregresi\u00f3n maligna del melanoma humano."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Teresa L\u00f3pez Mitxelena <\/strong><\/h2>\n<p>La interleucina-10 (il-10) es una citocina supresora de la proliferaci\u00f3n espec\u00edfica de los linfocitos t despu\u00e9s de la presentaci\u00f3n antig\u00e9nica. Su efecto se produce a trav\u00e9s de la inhibici\u00f3n de la expresi\u00f3n de los ant\u00edgenos de la clase ii del complejo mayor de histocompatibilidad y de la mol\u00e9cula de adhesi\u00f3n intercelular-1 (icam-1). Por el  contrario, la il-2 es una mol\u00e9cula estimuladora de la respuesta inmune antitumoral. En trabajos previos hemos demostrado que diferentes l\u00edneas celulares de melanoma humano expresan el receptor de la interleucina-2 (ril-2) y sintetizan il-2, por lo que esta citocina puede ser utilizada como factor de crecimiento paracrino y\/o autocrino.  con el objeto de valorar la respuesta inmune antitumoral que se produce durante la evoluci\u00f3n de los pacientes con melanoma y su implicaci\u00f3n en la evoluci\u00f3n metast\u00e1tica, en el presente trabajo hemos estudiado la participaci\u00f3n de la il-10 e icam-1 en la progresi\u00f3n maligna del melanoma y su modulaci\u00f3n por la il-2. Para ello, hemos determinado los niveles s\u00e9ricos de il-10 e icam-1s en 188 pacientes con melanoma durante 4 a\u00f1os de seguimiento y los hemos analizado junto a los niveles del receptor soluble de la il-2 (ril-2s). Por otra parte, ya que las c\u00e9lulas de melanoma expresan il-10, hemos estudiado el efecto in vitro de la il-2 sobre la expresi\u00f3n y s\u00edntesis de il-10 y la expresi\u00f3n de los ant\u00edgenos hla-dr e icam-1 en dos l\u00edneas de melanoma humano a375 y hs294t. Los resultados han mostrado un incremento de los niveles s\u00e9ricos de ril-2s, il-10 e icam-1s que est\u00e1n significativamente relacionados con la evoluci\u00f3n metast\u00e1tica del melanoma. Por otro lado, el tratamiento de las c\u00e9lulas del melanoma con il-2 estimula la expresi\u00f3n y s\u00edntesis de il-10 en ambas l\u00edneas celulares y adem\u00e1s, modula la expresi\u00f3n en la membrana de las c\u00e9lulas tumorales de los ant\u00edgenos hla-dr e icam-1. estos resultados sugieren que la inmunosupresi\u00f3n observada en los<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio de la interleucina-10 y de la mol\u00e9cula de adhesi\u00f3n intercelular-1 en la pregresi\u00f3n maligna del melanoma humano.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio de la interleucina-10 y de la mol\u00e9cula de adhesi\u00f3n intercelular-1 en la pregresi\u00f3n maligna del melanoma humano. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Teresa L\u00f3pez Mitxelena <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Pa\u00eds vasco\/euskal herriko unibertsitatea<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 02\/04\/2004<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Boyano L\u00f3pez M. Dolores<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Juan  Miguel Ar\u00e9chaga mart\u00ednez <\/li>\n<li>gorka P\u00e9rez-yarza p\u00e9rez-irezabal (vocal)<\/li>\n<li>antoni Castells rodellas (vocal)<\/li>\n<li>Francisco Camacho mart\u00ednez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Teresa L\u00f3pez Mitxelena La interleucina-10 (il-10) es una citocina supresora de la proliferaci\u00f3n espec\u00edfica de los linfocitos [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[12909],"tags":[217,46876,3672,63939,13203,83562],"class_list":["post-29574","post","type-post","status-publish","format-standard","hentry","category-pais-vasco-euskal-herriko-unibertsitatea","tag-antoni-castells-rodellas","tag-boyano-lopez-m-dolores","tag-francisco-camacho-Martinez","tag-gorka-perez-yarza-perez-irezabal","tag-juan-miguel-arechaga-Martinez","tag-teresa-lopez-mitxelena"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/29574","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=29574"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/29574\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=29574"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=29574"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=29574"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}