{"id":29639,"date":"2018-03-09T09:22:51","date_gmt":"2018-03-09T09:22:51","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/utilidad-de-atorvastatina-en-el-trasplante-alogenico-de-islotes-de-pancreas\/"},"modified":"2018-03-09T09:22:51","modified_gmt":"2018-03-09T09:22:51","slug":"utilidad-de-atorvastatina-en-el-trasplante-alogenico-de-islotes-de-pancreas","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/utilidad-de-atorvastatina-en-el-trasplante-alogenico-de-islotes-de-pancreas\/","title":{"rendered":"Utilidad de atorvastatina en el trasplante alog\u00e9nico de islotes de p\u00e1ncreas"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Carmen Herrera Vela <\/strong><\/h2>\n<p>Introducci\u00f3n  el tratamiento con estatinas se ha mostrado eficaz en los trasplantes de \u00f3rgano s\u00f3lido en humanos. En modelos experimentales de trasplante, pravastatina mejora la evoluci\u00f3n del isoinjerto, aloinjerto y autotrasplante de islotes de langerhans. Adem\u00e1s, se ha demostrado que disminuye la apoptosis celular en islotes de p\u00e1ncreas tratados con simbastatina.  objetivo  determinar si el tratamiento con atorvastatina mejora la evoluci\u00f3n del trasplante alog\u00e9nico de islotes de p\u00e1ncreas, determinar si el tratamiento con atorvastatina permite reducir el n\u00famero de islotes necesarios para conseguir la normoglucemia en el trasplante alog\u00e9nico de islotes de p\u00e1ncreas e investigar las causas de los efectos beneficiosos del tratamiento con atorvastatina, especialmente del efecto sobre la apoptosis  en c\u00e9lulas de islotes trasplantados.  material y m\u00e9todos  se utilizaron ratones macho swiss nmri diab\u00e9ticos tras inyecci\u00f3n de estreptozotocina intraperitoneal (180 mg\/kg). El aislamiento de islotes de p\u00e1ncreas se realiz\u00f3 tras digesti\u00f3n con colagenasa (2mg\/ml), trasplant\u00e1ndolos al d\u00eda siguiente bajo la c\u00e1psula renal izquierda. Se tras plantaron en grupos de 300, 400, 500 \u00f3 600 islotes, y todos los ratones recibieron tratamiento con cilosporina por v\u00eda oral a dosis de 20 mg\/kg, desde el d\u00eda del trasplante hasta el d\u00eda 30 postrasplante, momento en que termin\u00f3 el estudio. La mitad de los animales de cada grupo recibi\u00f3 tratamiento con atorvastatina por sondaje esof\u00e1gico a dosis de 40 mg\/kg\/d\u00eda desde el d\u00eda anterior al trasplante hasta el final del estudio. Se realiz\u00f3 control de peso y glucemia cada dos d\u00edas, y determinaci\u00f3n de lahemoglobina glucosilada (hba1c) el d\u00eda del trasplante y al final del estudio. Se determin\u00f3 el contenido de insulina de los p\u00e1ncreas, y se estudiaron morfol\u00f3gicamente los injertos al final del estudio. Se incluy\u00f3 un grupo control de animales diab\u00e9ticos tratados con ciclosporina y atorvas<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Utilidad de atorvastatina en el trasplante alog\u00e9nico de islotes de p\u00e1ncreas<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Utilidad de atorvastatina en el trasplante alog\u00e9nico de islotes de p\u00e1ncreas <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Carmen Herrera Vela <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Universitat de val\u00e9ncia (estudi general)<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 15\/04\/2004<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Ponce Marco Jos\u00e9 Luis<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: daniel Casanova rituerto <\/li>\n<li>emiliano Astudillo pombo (vocal)<\/li>\n<li>Carlos S\u00e1nchez Juan (vocal)<\/li>\n<li>Javier Deus fombellida (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Carmen Herrera Vela Introducci\u00f3n el tratamiento con estatinas se ha mostrado eficaz en los trasplantes de \u00f3rgano [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[1],"tags":[63676,83710,10546,83711,55806,19380],"class_list":["post-29639","post","type-post","status-publish","format-standard","hentry","category-sin-categoria","tag-carlos-sanchez-juan","tag-carmen-herrera-vela","tag-daniel-casanova-rituerto","tag-emiliano-astudillo-pombo","tag-javier-deus-fombellida","tag-ponce-marco-jose-luis"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/29639","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=29639"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/29639\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=29639"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=29639"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=29639"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}