{"id":29640,"date":"2018-03-09T09:22:51","date_gmt":"2018-03-09T09:22:51","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/efectos-del-fk506-un-ligando-de-inmunofilinas-sobre-la-regeneracion-nerviosa\/"},"modified":"2018-03-09T09:22:51","modified_gmt":"2018-03-09T09:22:51","slug":"efectos-del-fk506-un-ligando-de-inmunofilinas-sobre-la-regeneracion-nerviosa","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/efectos-del-fk506-un-ligando-de-inmunofilinas-sobre-la-regeneracion-nerviosa\/","title":{"rendered":"Efectos del fk506, un ligando de inmunofilinas, sobre la regeneraci\u00f3n nerviosa"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Esther Udina Bonet <\/strong><\/h2>\n<p>El objetivo de esta tesis era testar los efectos del fk506 (o tacrolimus), un f\u00e1rmaco inmunodepresor selectivo que se liga a las inmunofilias, proteinas citoplasm\u00e1ticas muy ubicuas en el organismo. Los ligandos de inmunofilinas, la familia de f\u00e1rmacos a los que pertenece el fk506 (as\u00ed como la ciclosporina a y la rapamicina), han demostrado tener efectos neurotr\u00f3ficos y neuroprotectores muy prometedores a nivel experimental.  nos hemos concentrado en los probables efectos neurotr\u00f3ficos del fk506 en la regeneraci\u00f3n del nervio perif\u00e9rico despu\u00e9s de lesiones. Se han utilizado dos modelos de lesi\u00f3n:  1,- lesi\u00f3n leve, con buena recuperaci\u00f3n funcional de por si, sin necesidad de reparaci\u00f3n quir\u00fargica: aplastamiento del nervio ci\u00e1tico (crush).  2,- lesi\u00f3n severa, sin recuperaci\u00f3n funcional si no se repara quir\u00fargicamente; resecci\u00f3n amplia del nervio ci\u00e1tico y posterior reparaci\u00f3n (mediante un injerto de origen aut\u00f3logo o alog\u00e9nico, o mediante tubulizaci\u00f3n -tubo de silicona, tubo de col\u00e1geno o tubo de col\u00e1geno con c\u00e9lulas de schwann alog\u00e9niques en su interior).  los resultados obtenidos en los diferentes estudios muestran que la administraci\u00f3n de fk506 acelera la tasa de regeneraci\u00f3n axonal despu\u00e9s de lesiones del nervio perif\u00e9rico y mejora el grado de reinervaci\u00f3n alcanzado. El estudio muestra que hay dos picos de m\u00e1ximo efecto del fk506 sobre la velocidad de regeneraci\u00f3n, a 0.2 y 5 mg\/kg, si bien la dosis de 5 mg\/kg permite alcanzar unos mejores niveles de recuperaci\u00f3n funcional en seguimientos largos que la dosis de 0.2 mg\/kg. No obstante, las dos dosis incrementan la reinervaci\u00f3n de los \u00f3rganos diana  y la regeneraci\u00f3n axonal en proporciones similares. en lesiones severas por resecci\u00f3n de un segmento del nervio, donde la reparaci\u00f3n quir\u00fargica es determinante para el \u00e9xito de la regeneraci\u00f3n, los efectos de la administraci\u00f3n de fk506 depende del tipo de m\u00e9todo reparativo utilizado. as\u00ed, en las r<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Efectos del fk506, un ligando de inmunofilinas, sobre la regeneraci\u00f3n nerviosa<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Efectos del fk506, un ligando de inmunofilinas, sobre la regeneraci\u00f3n nerviosa <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Esther Udina Bonet <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 15\/04\/2004<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Xavier Navarro Acebes<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: albert Badia sancho <\/li>\n<li>marina Mata (vocal)<\/li>\n<li>Jos\u00e9 enrique Esquerda colell (vocal)<\/li>\n<li>josep Valls sol\u00e9 (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Esther Udina Bonet El objetivo de esta tesis era testar los efectos del fk506 (o tacrolimus), un [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[1],"tags":[46,83712,18863,83714,83713,13724],"class_list":["post-29640","post","type-post","status-publish","format-standard","hentry","category-sin-categoria","tag-albert-badia-sancho","tag-esther-udina-bonet","tag-jose-enrique-esquerda-colell","tag-josep-valls-sole","tag-marina-mata","tag-xavier-navarro-acebes"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/29640","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=29640"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/29640\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=29640"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=29640"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=29640"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}