{"id":29715,"date":"2018-03-09T09:22:58","date_gmt":"2018-03-09T09:22:58","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/analisis-de-las-protea%c2%adnas-nucleolares-nopa100-y-nopa64-en-relacion-con-la-proliferacion-celular-en-allium-cepa-l\/"},"modified":"2018-03-09T09:22:58","modified_gmt":"2018-03-09T09:22:58","slug":"analisis-de-las-protea%c2%adnas-nucleolares-nopa100-y-nopa64-en-relacion-con-la-proliferacion-celular-en-allium-cepa-l","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/analisis-de-las-protea%c2%adnas-nucleolares-nopa100-y-nopa64-en-relacion-con-la-proliferacion-celular-en-allium-cepa-l\/","title":{"rendered":"An\u00e1lisis de las prote\u00ednas nucleolares nopa100 y nopa64 en relaci\u00f3n con la proliferaci\u00f3n celular en allium cepa l."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Fernando Gonz\u00e1lez Camacho <\/strong><\/h2>\n<p>En este trabajo se han analizado las propiedades f\u00edsico-qu\u00edmicas de las prote\u00ednas nucleolares nopa100 y nopa64, que son mayoritarias en la fracci\u00f3n soluble de los n\u00facleos de c\u00e9lulas en proliferaci\u00f3n, aunque tambi\u00e9n presentan niveles significativos en la fracci\u00f3n m\u00e1s insoluble (matriz nuclear).  las prote\u00ednas mostraron un incremento en la fase g2 del ciclo celular. mediante inmunocitoqu\u00edmica a nivel de microscop\u00eda \u00f3ptica y electr\u00f3nica, se observ\u00f3 una distribuci\u00f3n desigual dentro del nucleolo, apareciendo principalmente en los componentes fibrilares. Un an\u00e1lisis mediante western blot con anticuerpo anti-nopa100 mostr\u00f3 una banda principal a 100 kda junto con una serie de prote\u00ednas relacionadas con ella, de menor tama\u00f1o. Este resultado sugiere que la nopa100 sufre un proceso fisiol\u00f3gico de maduraci\u00f3n proteol\u00edtica, lo que fue confirmado mediante un tratamiento con un inhibidor de proteasas general, la leupeptina. Se observ\u00f3 una relaci\u00f3n entre el incremento de la actividad del nucleolo y la actividad de la nopa100, el progreso en el ciclo celular y la maduraci\u00f3n de la prote\u00edna.  hemos demostrado que las variaciones de la napa100 durante la progresi\u00f3n del ciclo celular van acompa\u00f1adas de una reorganizaci\u00f3n estructural del nucleolo, que es expresada en cambios cuantitativos de la contribuci\u00f3n relativa de los diferentes subcomponentes nucleolar para cada uno de los per\u00edodos de la interfase.  el conjunto de sus propiedades identifica a la nopa100 como una prote\u00edna hom\u00f3loga a la nucleolina de mam\u00edferos y a la nopa64 como un fragmento estable de la nopa100. Este hecho, junto con el an\u00e1lisis detallado de las secuencias de amino\u00e1cidos del resto de \u00abprote\u00ednas semejantes a nucleolina\u00bb en otros organismos, confirma la alta conservaci\u00f3n evolutiva que presenta, la cual es la consecuencia del papel funcional extraordinariamente relevante de esta prote\u00edna en la vida de la c\u00e9lula, interviniendo decisivamente en la re<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>An\u00e1lisis de las prote\u00ednas nucleolares nopa100 y nopa64 en relaci\u00f3n con la proliferaci\u00f3n celular en allium cepa l.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 An\u00e1lisis de las prote\u00ednas nucleolares nopa100 y nopa64 en relaci\u00f3n con la proliferaci\u00f3n celular en allium cepa l. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Fernando Gonz\u00e1lez Camacho <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 21\/04\/2004<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Francisco Javier Medina D\u00edaz<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: amparo Cano garcia <\/li>\n<li>Manuel Echevarria (vocal)<\/li>\n<li> Consuelo de la torre Garc\u00eda consuelo (vocal)<\/li>\n<li>Ana Mar\u00eda Vazquez l\u00f3pez-lomo (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Fernando Gonz\u00e1lez Camacho En este trabajo se han analizado las propiedades f\u00edsico-qu\u00edmicas de las prote\u00ednas nucleolares nopa100 [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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