{"id":29725,"date":"2018-03-09T09:22:58","date_gmt":"2018-03-09T09:22:58","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/control-reca%c2%adproco-entre-la-corteza-prefrontal-y-los-nucleos-del-rafe-papel-de-los-receptores-de-serotonina\/"},"modified":"2018-03-09T09:22:58","modified_gmt":"2018-03-09T09:22:58","slug":"control-reca%c2%adproco-entre-la-corteza-prefrontal-y-los-nucleos-del-rafe-papel-de-los-receptores-de-serotonina","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/barcelona\/control-reca%c2%adproco-entre-la-corteza-prefrontal-y-los-nucleos-del-rafe-papel-de-los-receptores-de-serotonina\/","title":{"rendered":"Control rec\u00edproco entre la corteza prefrontal y los n\u00facleos del rafe. papel de los receptores de serotonina"},"content":{"rendered":"<h2>Tesis doctoral de <strong> M. Victoria Puig Velasco <\/strong><\/h2>\n<p>La corteza prefrontal (cpf) juega un papel crucial en funciones cerebrales superiore tan complejas como la cognici\u00f3n, siendo la corteza cerebral m\u00e1s evolucionada en humanos. La corteza cerebral est\u00e1 densamente inervada por aferencias procedentes de los sistemas amin\u00e9rgicos que se originan en el cerebro medio: los n\u00facleos del rafe (nr), el locus coeruleus y el \u00e1rea tegmental ventral, que a trav\u00e9s de la liberaci\u00f3n de serotonina, noradrenalina y dopamina, respectivamente, ejercen un papel neuromodulador de la actividad cortical. Tanto estudios de neuroimagen como post-mortem ha implicado a la cpf medial en patolog\u00e1is psiqui\u00e1tricas sveras como la depresi\u00f3n o la esquizofrenia. A su vez, la mayor parte de los f\u00e1rmacos antidepresivos utilizados actualmente (ssris-inhibodres selectivos de la recapataci\u00f3n de serotonina-) tienen al sistema sertonin\u00e9rgico como diana terap\u00e9utica. la cpf medial expresa receptores para la serotonina 5-ht1a (inhibitorios) y 5-ht2a (exitatorios) de forma muy abundante, pero se desconoce su localizaci\u00f3n exacta en la corteza y su papel funcional.  en la presente tesis se ha estudiado el circuito que se es tablece entre la cpf medial y los n\u00facleos dorsal y medial del rafe (ndr y nmr) con el objetivo principal de conocer c\u00f3mo se controlan rec\u00edprocamente estas dos \u00e1reas cerebrales y qu\u00e9 efectos ejercen los antidepresivos y antipsic\u00f3ticos sobre dicho circuito. Para ello hemos utilizado microdi\u00e1lisis intracerebral en rata despeirta y electrofisiolog\u00eda unitaria extracelular en ratas y ratones anestesiados con hidrato de cloral.  espec\u00edficamente, hemos descrito el mecanismo utilizado por la cpf medial para controlar la actividad de las neuronas serotonin\u00e9rgicas del ndr. Este mecanismo implica una excitaci\u00f3n inicla glutamat\u00e9rgica a trav\u00e9s de receptores inonotr\u00f3picos del glutamato (nmda y ampa\/ka), tras lo cual se produce un  aumento en la liberaci\u00f3n de serotonina en el ndr que inhibe a otras neurona<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Control rec\u00edproco entre la corteza prefrontal y los n\u00facleos del rafe. papel de los receptores de serotonina<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Control rec\u00edproco entre la corteza prefrontal y los n\u00facleos del rafe. papel de los receptores de serotonina <\/li>\n<li><strong>Autor:<\/strong>\u00a0 M. Victoria Puig Velasco <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 22\/04\/2004<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> <\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Ignacio Morgado Bernal <\/li>\n<li>Emilio Geijo Barrientos (vocal)<\/li>\n<li>Roser Cortes Colome (vocal)<\/li>\n<li>Luisa Ugedo Urruela (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de M. Victoria Puig Velasco La corteza prefrontal (cpf) juega un papel crucial en funciones cerebrales superiore tan [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[951,957,3352,1408,8334],"tags":[33129,11357,13466,83919,20276],"class_list":["post-29725","post","type-post","status-publish","format-standard","hentry","category-barcelona","category-farmacologia","category-fisiologia-del-sistema-nervioso-central","category-psiquiatria","category-ubicacion-activa-y-receptores","tag-emilio-geijo-barrientos","tag-ignacio-morgado-bernal","tag-luisa-ugedo-urruela","tag-m-victoria-puig-velasco","tag-roser-cortes-colome"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/29725","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=29725"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/29725\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=29725"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=29725"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=29725"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}