{"id":29744,"date":"2018-03-09T09:23:00","date_gmt":"2018-03-09T09:23:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/muerte-celular-durante-la-reperfusion-miocardica-mecanismos-y-nuevas-dianas-terapeuticas\/"},"modified":"2018-03-09T09:23:00","modified_gmt":"2018-03-09T09:23:00","slug":"muerte-celular-durante-la-reperfusion-miocardica-mecanismos-y-nuevas-dianas-terapeuticas","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/muerte-celular-durante-la-reperfusion-miocardica-mecanismos-y-nuevas-dianas-terapeuticas\/","title":{"rendered":"Muerte celular durante la reperfusi\u00f3n mioc\u00e1rdica. mecanismos y nuevas dianas terape\u00faticas"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Javier Inserte Igual <\/strong><\/h2>\n<p>El da\u00f1o mioc\u00e1rdico por reperfusi\u00f3n describe el fen\u00f3meno por el cual la restauraci\u00f3n del flujo snagu\u00edneo desencadena la muerte de tejido mioc\u00e1rdio que ha sobrevivido a un periodo isqu\u00e9mico previo. Esta muerte celular puede ser por necrosis o por apoptosis.  la contribuci\u00f3n de la muerte por apoptosis al total de la muerte celular continua siendo objeto de debate. En la primera parte de esta tesis se demuestra que la simulaci\u00f3n de isquemia\/reperfusi\u00f3n en miocitos aislados y coraz\u00f3n aislado de rata no solo no induce muerte por apoptosis sino que genera un efecto protector frente a est\u00edmulos externos proapopt\u00f3ticos por un mecanismo asociado a una sobreexpresi\u00f3n del programa g\u00e9nico antiapopt\u00f3tico.  la mayor parte de la muerte celular que tiene lugar durante la reperfusi\u00f3n se produce durante los primeros minutos en forma de necrosis. Esta se atribuye a la hipercontractura, acortamiento extremo que sufren los miocitos en el inicio de la reperfusi\u00f3n debido a la reactivaci\u00f3n de la s\u00edntesis de atp en presencia de la sobrecarga de ca2+ citos\u00f3lico que se produce durante la deprivaci\u00f3n eneg\u00e9tica. En la segunda p arte de esta tesis se propone dos nuevos mecanismos de prevenci\u00f3n de la muerte inmediata por reperfusi\u00f3n dirigidos a disminuir por v\u00edas distintas el desarrollo de la hipercontractura:  1,- inhibici\u00f3n de la funci\u00f3n contr\u00e1ctil durante los primero minutos de la reperfusi\u00f3n mediante la estimulaci\u00f3n  de la s\u00edntesis de gmpc.  2,- disminuir de la sobrecarga de ca2+ citos\u00f3lico por inhibici\u00f3n de la forma reversa del intercambiador na+\/ca2+ (ncx) durante el inicio de la reperfusion.  en conclusi\u00f3n, los resultados obtenidos en estos estudios rlativizan la muerte por apoptosis tras isquemia\/reperfusi\u00f3n y acent\u00faan la importancia terap\u00e9utica de aquellas estrategias destinadas a prevenir el desarrollo de hipercontractura como modo de limitar el da\u00f1o letal por reperfusi\u00f3n.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Muerte celular durante la reperfusi\u00f3n mioc\u00e1rdica. mecanismos y nuevas dianas terape\u00faticas<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Muerte celular durante la reperfusi\u00f3n mioc\u00e1rdica. mecanismos y nuevas dianas terape\u00faticas <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Javier Inserte Igual <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 22\/04\/2004<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>David Garc\u00eda Dorado<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: pilar Tornos mas <\/li>\n<li>Fernando Picatoste ram\u00f3n (vocal)<\/li>\n<li>ester Sanz girgas (vocal)<\/li>\n<li>magdalena Heras fortuny (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Javier Inserte Igual El da\u00f1o mioc\u00e1rdico por reperfusi\u00f3n describe el fen\u00f3meno por el cual la restauraci\u00f3n del [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[1],"tags":[83960,83961,32902,83959,45774,1166],"class_list":["post-29744","post","type-post","status-publish","format-standard","hentry","category-sin-categoria","tag-david-garcia-dorado","tag-ester-sanz-girgas","tag-fernando-picatoste-ramon","tag-javier-inserte-igual","tag-magdalena-heras-fortuny","tag-pilar-tornos-mas"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/29744","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=29744"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/29744\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=29744"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=29744"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=29744"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}