{"id":29787,"date":"2018-03-09T09:23:04","date_gmt":"2018-03-09T09:23:04","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/mecanismos-moleculares-en-el-deterioro-cognitivo-inducido-por-agentes-serotonergicos\/"},"modified":"2018-03-09T09:23:04","modified_gmt":"2018-03-09T09:23:04","slug":"mecanismos-moleculares-en-el-deterioro-cognitivo-inducido-por-agentes-serotonergicos","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/navarra\/mecanismos-moleculares-en-el-deterioro-cognitivo-inducido-por-agentes-serotonergicos\/","title":{"rendered":"Mecanismos moleculares en el deterioro cognitivo inducido por agentes seroton\u00e9rgicos"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Sonia Moyano  Dom\u00ednguez <\/strong><\/h2>\n<p>En las fases tempranas del aprendizaje, es imprescindible una adecuada transmisi\u00f3n glutamat\u00e9rgica, mientras que el sistema seroton\u00e9rgico parece ejercer una acci\u00f3n moduladora sobre otros sistemas de neurotransmisi\u00f3n. en este trabajo, se encontr\u00f3 un d\u00e9ficit de aprendizaje de evitaci\u00f3n pasiva en ratas como consecuencia de la administraci\u00f3n aguda del agonista de receptores 5-ht1a, 8-oh-dpat, as\u00ed como de la administraci\u00f3n aguda de las neurotoxinas seroton\u00e9rgicas metilendioximetanfetamina (mdma, \u00abextasis\u00bb) y p-cloroanfetamina (pca). Se estudiaron los posibles mecanismos moleculares implicados en el d\u00e9ficit cognitivo inducido por estos agentes.  una hora despu\u00e9s de la inducci\u00f3n del aprendizaje, se encontr\u00f3 en el hipocampo de los animales control, un aumento de los niveles en membrana y de la actividad enzim\u00e1tica de ca2+\/calmodulin-kinasa ii (camkii), de la actividad de la prote\u00edn-kinasa a (pka) y de los niveles en membrana de la subunidad nr1 y su forma fosforilada en ser-897, as\u00ed como de la forma fosforilada en ser de la subunidad nr2b del receptor glutamat\u00e9rgico nmda. La administraci\u00f3n previa al aprendizaje de 8-oh-dpat, evit\u00f3 el aumento de la actividad de camkii as\u00ed como de su translocaci\u00f3n a la membrana y uni\u00f3n a la subunidad nr2b, eventos fundamentales para la consolidaci\u00f3n de la memoria en el hipocampo. el agonista seroton\u00e9rgico indujo tambi\u00e9n un aumento en la actividad de la prote\u00edn-fosfata 1 (pp1), que podr\u00eda ser la causa de la disminuci\u00f3n en la actividad de camkii, y que podr\u00eda ser causado por el descenso encontrado en la actividad de pka. La administraci\u00f3n de 8-oh-dpat tambi\u00e9n evit\u00f3 los efectos asociados al aprendizaje de la subunidades del receptor nmda, efectos que podr\u00edan estar asociados con las modificaciones enzim\u00e1ticas y que, en su conjunto, conducen a una menor actividad sin\u00e1ptica.  a su vez, la administraci\u00f3n aguda previa a la inducci\u00f3n del aprendizaje de mdma y pca previno el aumento aso<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Mecanismos moleculares en el deterioro cognitivo inducido por agentes seroton\u00e9rgicos<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Mecanismos moleculares en el deterioro cognitivo inducido por agentes seroton\u00e9rgicos <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Sonia Moyano  Dom\u00ednguez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Navarra<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 23\/04\/2004<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Joaquin Del Rio Zambrana<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Antonio Rodr\u00edguez artalejo <\/li>\n<li>ignacio Lizasoain hernandez (vocal)<\/li>\n<li>Mar\u00eda isabel Colado megia (vocal)<\/li>\n<li>Mar\u00eda  Jes\u00fas Lopez zabalza (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Sonia Moyano Dom\u00ednguez En las fases tempranas del aprendizaje, es imprescindible una adecuada transmisi\u00f3n glutamat\u00e9rgica, mientras que [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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