{"id":29813,"date":"2018-03-09T09:23:07","date_gmt":"2018-03-09T09:23:07","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/papel-del-enzima-oxido-na%c2%adtrico-sintasa-en-la-patogenia-de-la-poliposis-nasosinusal\/"},"modified":"2018-03-09T09:23:07","modified_gmt":"2018-03-09T09:23:07","slug":"papel-del-enzima-oxido-na%c2%adtrico-sintasa-en-la-patogenia-de-la-poliposis-nasosinusal","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/papel-del-enzima-oxido-na%c2%adtrico-sintasa-en-la-patogenia-de-la-poliposis-nasosinusal\/","title":{"rendered":"Papel del enzima \u00f3xido n\u00edtrico sintasa en la patogenia de la poliposis nasosinusal"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Paloma Escobar Sanz-dranguet <\/strong><\/h2>\n<p>El estudio se ha realizado en dos grupos, un brazo estaba constituido por 15 pacientes diagnosticados de poliposis nasosinusal, y el otro por un grupo control de 11 pacientes que iban a ser intervenidos de septoplastia.  el estudio estad\u00edstico se realiz\u00f3 mediante el programa spss para windows, utilizando pruebas no param\u00e9tricas.  1,- se analizaron mediante western blot los niveles de expresi\u00f3n de prote\u00edna nose en 8 pacientes y 6 controles, demostrando la presencia de una banda de 140 kda en las muestras de mucosas nasal sana y de p\u00f3lipos nasales, lo que indica la expresi\u00f3n de la prote\u00edna nose en estos tejidos. El densitometrado de nose mostr\u00f3 un valor medio de 3.53 en los controles y 12.03 en los pacientes (medici\u00f3n en unidades arbitrarias). Esta diferencia fue estad\u00edsticamente significativa (p menor 0,01).  2,- la localizaci\u00f3n de la expresi\u00f3n de enos e inos se estudi\u00f3 con t\u00e9cnicas de inmunohistoqu\u00edmica medainte anticuerpos policlonales anti enos y anti inos, encontrando que la prote\u00edna nose se localiza en el endotelio, tanto en mucosa normal, como en p\u00f3lipos, con mayor intensidad en estos \u00faltimos. la nosi se localiza en el epitelio, con una tinci\u00f3n muy d\u00e9bil en la mucosa normal, y muy intensa en los p\u00f3lipos.  3,- se prepararon extractos citiplasm\u00e1ticos de las biopsias de 8 pacientes y 6 controles. Los lisados citopl\u00e1smicos se incubaron con una sonda utr-l marcada procedente del arnm de nose.  posteriormente se realiz\u00f3 una electroforesis para detectar los complejos formados por la uni\u00f3n arnm-prote\u00edna. La adici\u00f3n de una sonda marcada (utr-l) a extractos citoplasm\u00e1ticos de tejido nasal, resulta en un cambio en la movilidad de las bandas del gel, formando una banda de 60 kd, con una intensidad mucho mayor en las muestras obtenidas de mucosa nasal de los controles que en las obtenidas de p\u00f3lipos de los pacientes. Al realizar el an\u00e1lisis del densitometrado los valores encontrados en los p\u00f3lipos eran pr\u00e1ctic<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Papel del enzima \u00f3xido n\u00edtrico sintasa en la patogenia de la poliposis nasosinusal<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Papel del enzima \u00f3xido n\u00edtrico sintasa en la patogenia de la poliposis nasosinusal <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Paloma Escobar Sanz-dranguet <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 26\/04\/2004<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Francisco M\u00e1rquez Dorsch<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jos\u00e9 Antonio Rodr\u00edguez montes <\/li>\n<li>ricardo Jos\u00e9 Bosch mart\u00ednez (vocal)<\/li>\n<li>mercedes Ruiz moreno (vocal)<\/li>\n<li>Jes\u00fas De la osada Garc\u00eda (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Paloma Escobar Sanz-dranguet El estudio se ha realizado en dos grupos, un brazo estaba constituido por 15 [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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