{"id":29834,"date":"2018-03-09T09:23:09","date_gmt":"2018-03-09T09:23:09","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/efecto-de-los-inhibidores-de-la-fosfodiesterasa-5-en-la-arteria-coronaria-y-vasos-utilizados-en-el-bypass-coronario\/"},"modified":"2018-03-09T09:23:09","modified_gmt":"2018-03-09T09:23:09","slug":"efecto-de-los-inhibidores-de-la-fosfodiesterasa-5-en-la-arteria-coronaria-y-vasos-utilizados-en-el-bypass-coronario","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/efecto-de-los-inhibidores-de-la-fosfodiesterasa-5-en-la-arteria-coronaria-y-vasos-utilizados-en-el-bypass-coronario\/","title":{"rendered":"Efecto de los inhibidores de la fosfodiesterasa 5 en la arteria coronaria y vasos utilizados en el bypass coronario"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Bel\u00e9n Torondel L\u00f3pez <\/strong><\/h2>\n<p>La revascularizaci\u00f3n coronaria es el tratamiento de elecci\u00f3n de muchos enfermos con isquemia coronaria. Para la realizaci\u00f3n del bypass aorto-coronario se emplean las arterias mamaria interna y radial, y la vena safena.  los injertos vasculares tienen tendencia a presentar vasoespasmos durante la operaci\u00f3n. As\u00ed se ha desarrollado estudios farmacol\u00f3gicos paralelamente al desarrollo de la t\u00e9cnica de bypass coronario, ya que es importante conocer los mecanismos de acci\u00f3n de diversas sustancias relajantes en los distintos injertos vasculares.  los inhibidores de la fosfodiesterasas constituyen un nuevo grupo de sustancias vasodilatadoras cuyos efectos y mecanismos de acci\u00f3n en los injertos utilizados en el bypass coronario no est\u00e1n bien establecidos. El objetivo general de este trabajo es analizar la respuesta de segmentos de arteria coronaria y vasos utilizados en el bypass coronario (arterias mamaria interna, radial y vena safena) a diferentes est\u00edmulos farmacol\u00f3gicos. Para la realizaci\u00f3n de este trabajo se utilizaron segmentos de arterias coronarias, mamaria interna y radial y vena safena, que se montaron en un ba\u00f1o de \u00f3rganos para su posterior registro de tensi\u00f3n isom\u00e9trica. Estudiamos la respuesta de estos vasos a dos inhibidores de la fosfodiesterasa 5 (sildenafilo y zaprinast), a un inhibidor de la fosfodiesterasas 3 (milrinona) y a un inhibidor inespec\u00edfico de las fosfodiesterasas (papaverina). Tambi\u00e9n valoramos los efectos de los inhibidores de la fosfodiesterasa 5 sobre la respuesta al nitroprusiato s\u00f3dico. Los resultados indican que: sildenafilo y zaprinast producen relajaci\u00f3n de la arteria coronaria y los vasos utilizados en el bypass coronario por incrementar los niveles de gmpc impidiendo su degradaci\u00f3n. En los vasos utilizados en el bypass coronario la relajaci\u00f3n producida por sildenafilo y zaprinast no requieren de la activaci\u00f3n de la guanilato ciclasa por el no. Sin embargo en la arteria coronaria este<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Efecto de los inhibidores de la fosfodiesterasa 5 en la arteria coronaria y vasos utilizados en el bypass coronario<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Efecto de los inhibidores de la fosfodiesterasa 5 en la arteria coronaria y vasos utilizados en el bypass coronario <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Bel\u00e9n Torondel L\u00f3pez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Universitat de val\u00e9ncia (estudi general)<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 27\/04\/2004<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Pascual Medina Besso<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: salvador Lluch lopez <\/li>\n<li>nuria Fern\u00e1ndez monsalve (vocal)<\/li>\n<li>pascual Chuan nuez (vocal)<\/li>\n<li>Luis Monge sanchez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Bel\u00e9n Torondel L\u00f3pez La revascularizaci\u00f3n coronaria es el tratamiento de elecci\u00f3n de muchos enfermos con isquemia coronaria. [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[1],"tags":[84170,84171,5794,44934,44933,5797],"class_list":["post-29834","post","type-post","status-publish","format-standard","hentry","category-sin-categoria","tag-belen-torondel-lopez","tag-luis-monge-sanchez","tag-nuria-fernandez-monsalve","tag-pascual-chuan-nuez","tag-pascual-medina-besso","tag-salvador-lluch-lopez"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/29834","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=29834"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/29834\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=29834"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=29834"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=29834"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}